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Ketamine + Opiates

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blase deviant

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May 9, 2004
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Someone on here suggested using 25mg Ketamine to potentiate opiates, and said it worked far better than 30mg DXM. I also remember them saying to use 1/2 the opiate dose when on Ketamine.

This makes no sense to me, because I can't feel any effects from 30mg DXM alone, and I always took around 1/2 (sometimes a tiny bit more) with DXM, whereas you can feel definite recreational effects from 25mg K (I know now that I have a feel for it 25mg isn't enough, but I did 25mg my first time and was floored, whereas I had to do like 180-220mg DXM my 1st time).

Thanks.

Was just wondering if there was absolutely no danger of excess respiratory depression so long as I cut my dose in half. I know 25mg K isn't a huge dose, but it is above threshold, so I just wanna make sure...

Also, if I use 25mg Ketamine for 2-3 days in this manner, will I get tolerance to Ketamine from such a low dose?
 
From experience...

25mg Ketamine/day should not produce tolerance. When I have Ketamine, I always use 10 - 30mg/day for its therapeutic effects, and it never seems to affect my tolerance for either the therapeutic or the recreational effects.

As for opiates - that much ketamine will not really potentiate opiates - it simply prevents opiate tolerance, and effectively so in my experience. It might increase the euphoria a little due to its dopaminergic effects - but also due to these same effects it will make it harder for you to nod. Your choice.

Again, this is just my experience.
 
You sure it doesn't potentiate opiates? Yesterday I only took 20mg + 5mg a few hours later of hydro, and I was nodding, and later breathing shallow enough that I was scared to go to bed. I used to take 40mg hydro for a high, and it didn't even get me that high...

But you're saying it's just a case of 1+1=2 not 4*4=16?

I also read a study where people had low-dose K the day after morphine and it brought back the morphine effects, which is scary since this is my second day of K+hydro/
 
Jamshyd said:
^ Interesting.

I was refering to taking Ketamine at the same time with an opiate.
Click to expand...

So was I.

The 20 + 5 later was my hydro. I meant I ate 20mg hydro, waited 35 min., snorted 25mg K, and then ate 5mg hydro a few hours later.

Oddly enough I don't think it works as well at preventing tolerance as DXM did for me, because I'm at 20 and not that high. Of course, I did have grapefruit juice yesterday.

Just to make sure, how long does hydro take to kick in orally on an empty stomach? I searched pubmed for various keywords, and used search here, nothing. I'm assuming 45 min., but it's been like an hour... and I don't wanna take more and have these kick in and be too high. I even broke each tab in half (too lazy to crush).
 
Sorry, when you said you took 20 and then and then a few hours later 5mg of hydro, I thought the 20 was refering to the K and the 5 was refering to the hydro.
 
Yeah, you were right about it not potentiating. This doesn't seem stronger at all. I did the same amount last night and it was stronger than this, so I don't even know if it works at preventing tolerance.

I don't want to mix DXM with it now though...

I'm also afraid to do more K since last night it starting out as a good high, but afterwards I was really, really sedated.

EDIT: This is screwy, it's like it's weaker at first, but as the K wears off, the hydro gets potentiated, WTF?
 
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Okay, one more retarded question... I feel a bit sleepy but probably from the DXM (I took a little extra to make sure since it came with no shotglass/erred on the side of excess) + my full dose of Celexa (20mg, when I've been taking 10mg a lot of nights).

I heard a report on PubMed comparing the effects of ketamine to the effects of (people, animals, I don't remember) ketamine given to subjects who had morphine the previous day, and the ketamine actually brought back the effects of the previous day's morphine/the second group displayed different effects than the first, greater sedation, etc.

I'm a bit paranoid about doing K today. I also had klonopin (skipped it for a few days because I was doing painkillers, was gonna do some today, but I dunno if DXM completely abolishes tolerance development, plus why not save them for a rainy day?), and I know I've mixed a crapload of klonopin/xanax + Ketamine before (complete waste of both drugs really, if you're trying to get high on the K... if you take a tiny bump on benzos you might feel 'higher', but on benzos, you just keep on compulsively snorting up K even though you don't feel that high)...

Anyway, sorry about the drawn out post, just wondering if it was safe to do Ketamine today if I did some hydro yesterday (25mg hydro + white grapefruit + DXM) and took a klonopin (I'm guessing this isn't an issue, since even though I skipped like 2 days or so I still have a tolerance I'd assume, it'd just be the thing to 'push me over' if the report about K bringing back the effects of opiates taken the previous day was true).

Thanks, and sorry for shitting up the advanced drug forum with pretty non-advanced discussion.... once again. It's like coming into a Calc II study group with Algebra questions because none of your algebra class knows the answers, when the Calc II group knows but are busy trying to study Calc II...

http://www.ncbi.nlm.nih.gov/entrez/...t_uids=3336011&query_hl=5&itool=pubmed_DocSum

Is the article I'm referring to, but is sloppy since it doesn't include the dosages of Ketamine/morphine given the first day for comparison...

EDIT: Snorted 40mg K (need to get a razor instead of plastic card, but can't walk with my surgery), a little bit of nausea, but I was nauseous before from pain/possibly antbiotics so that's not any opiate clue, sedation isn't an opiate clue since I feel a bit sedated on K (especially with some benzos sometimes) even if I'm not really sedated, no itches, but when I did K with hydro before, the hydro/itches/peak/whatever didn't occur until like 30-75 min. after the K wore off... but at least the pain in my balls doesn't make it uncomfortable to sit/I might be able to eat something... 80mg K but I can't tell if it's sedating me more than usual or if it's because I had coffee, or if I'm paranoid and drank more coffee because I had coffee before the K... ugh... want to do more K but unsure...

EDIT II: That fucking article makes me paranoid man. Or maybe all the caffeine I did is making the K make me paranoid. Either way, one second I'm worried about lingering DXM and hydro in my system and ODing on a mix due to it not being cleared, next second I want more K. Either way I'm not doing any more (total ~125mg).

EDIT III: Perfectly safe, article was bullshit, probably just felt a bit different because of the small amount of DXM interacting with the K, who knows... only now I can't sleep because I drank too much caffeine because I was paranoid, which lead me to drink more and more... ugh...

And once again, sorry for shitting up your forum.
 
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Jamshyd said:
From experience...

25mg Ketamine/day should not produce tolerance. When I have Ketamine, I always use 10 - 30mg/day for its therapeutic effects, and it never seems to affect my tolerance for either the therapeutic or the recreational effects.

As for opiates - that much ketamine will not really potentiate opiates - it simply prevents opiate tolerance, and effectively so in my experience. It might increase the euphoria a little due to its dopaminergic effects - but also due to these same effects it will make it harder for you to nod. Your choice.

Again, this is just my experience.
Click to expand...

Hmm... what about rather than taking a low dose of ketamine and a high dose of opioids... taking like 10mg of hydro, maybe 15mg, and then railing 100mg ketamine and taking a few more bumps as the ketamine wore off?

Would it give the ketamine more of an opiate/body-buzz feeling without being dangerous?
 
Hmm... why would it affect memory?

And if I were doing maybe 150mg or so over the course of the night (maybe a 75-100mg rail to start off, and then bumps up to 150-175 or so)... how much hydrocodone could I take before it became dangerous?

This should probably be moved to other drugs...
 
I was just thinking this the other day, how would the combo be? It seems in my head you wouldn't do alot of either one obviously and to start incredibly small, but does anyone have experience with doing K before doing the opiate, after, during?
 
The pain relief is increased (ket used in conjunction with morphine for burns patients gives superior pain relief), but bot sure if it increases all of the opiate effects. I know (from experience) that ket & methadone produces a much 'fluffier' experience! ;)
 
If you're using DXM to increase the effects of Opiates go for 100mg. I found that a very good dose!

Don't go higher though otherwise you'll get the DXM hallucinatory effects! :\
 
Hmm interesting. I'm going to try this as soon as I have both substances on hand :D . Should I start with K or the opiate (most likely oxy)? I figure I'll just alternate, start with a small bump of k/20mg oxy then go from there? Sounds pretty tasty to me

it just occur to me though that there could be some accompanying nausea with the combo, no? Opiates generally make me sick sometimes, although I'm used to it by now and means I'm high as shit lol. K only made feel sick if I ate and had like food in my stomach, but same with opiates. I probably wouldn't eat much around the time I did this.
 
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