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Ketamine, NOS & opiate potentiation and WD cessation + recreational HIGH RESURGENCE?

Drink_Tea_Love_Cat

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Ketamine, NOS & opiate potentiation and WD cessation + recreational HIGH RESURGENCE?

TLDR agmatine, NOS and ketamine COMPLETELY removing any WDS. Not only that, actually giving me a strong resurgence in a high from 18-24 hours ago... sedation, body buzz and all.


Not sure where to put this, maybe neurosciene-y. Certainly not sober living or harm reduction ;)

I'm interested in what exactly is going on here... I've been doing some silly experiments on myself today and in general over the last few weeks.

Post might be a bit sketchy because I'm just coming out of it, but I'm fascinated by this "discovery" and how it will aid my detox and future drug experiments.

context is - lately I'm trying to taper off kratom but kind of getting sidetracked by all the different comfort meds and other opiates I have access to atm and kind of just being... a bit of a silly addict I suppose. But I'm also doing science!


Yesterday I took healthy (as in large) doses of opium, codeine, DHC, potentiated with promethazine(after), diphenahydramine (sp?)(before), whole GF before, topped up with a little bit of kratom. Predominant buzz was morphine basically. Also took little bits of agmatine, theanine, tyrosine and rhodiola aaaand, kava, and caffeine and magnesium and nicotine gum. FYI This was all spread out and each time I monitored how I felt, not all at once.

Please do not comment on the stupidity of this combo, small doses are small doses, monitoring oneself is monitoring oneself. Ones decisions are ones decisions. But nonethless DISCLAIMER: DO NOT TRY THIS AT HOME, or if you do, research and keep doses tiny. (my doses of most of these were tiny apart from the opium and the codeine and the DHC, all were in the mid threshold range and spread out carefully enough for me to feel "safe", but combined was obviously combined effect).

All in all the high was very pleasurable, and worryingly so considering aforementioned kratom taper agenda. But that is besides the point, and not the point of this post....


Last night before bed I took some fat bumps of ketamine, not enormous, I always go slow with K. I was still in an opioid blanket. I lay down and prepared to trip my way to sleep. Strange thing was that didn't really happen. I just got more sedated and more body buzz and just felt overall way more high off the opiates. I tried a bit more, and still no real trippy experience. I was discouraged because I like the K-hole trip as it helps me get a new perspective when needed. But I knew to keep dosing was to be dangerous, and knew there were greater things at work than my experience could tell me. Eventually I slept like a baby (a drugged up fucker), and arose today after about 10 hours sleep or so, a little unsteady but functioning fine.

Basically then early today I took some agmatine, and 1 teaspoon of kratom early in the day, and I felt great for at least a couple hours and that's it. Also a coffee.

THE KEY POINT: Right now I should be in WDs, quite anxious ones at that. I should have been in WDs 3 hours ago. But I took 1 cannister of NOS (very slowly and with plenty of oxygen to accompany administration), and one small bump of Ketamine. I also took a little more agmatine, perhaps 400mg or even less. I also took EXTREMELY TINY bits of DLPA and Rhodiola, so I can't really include them with certainty into the picture. (I'm just a big fan of supporting my day with tiny amounts of various bulk amino acid or supplement powders these days. They seem to take the edge off and more...)

After the small amounts of NOS and the ketamine, I lay down and felt the warm blanket come again. I can't say it's the usual more stimulated opiate buzz that I like, as I like to be able to function when on opiates. I can say there was indeed some disorientation, so I had to lie down. But there was none of the usual trippy effect I get from ketamine on it's own. It merely felt like a full on opiate buzz. I feel like I probably don't even need any more opiates/opiods today and could probably have a comfortable sleep.

.. 1 teaspoon of Kratom should not be enough to hold me whatsoever for a whole day.

Why is that?



hope this is interesting for some - I did just go to ketamine wiki and see that it's not exactly totally novel to coadminister K and opiods, but nonetheless, I'm very surprised.
 
I should add that - the recreational dosages from yesterday were quite high doses for my average daily life. So there is probably some "afterglow" effect. Even so, I would have expected and usually do experience WDS by the 24 hour mark if I'm using stronger opiates, even with 1 kratom teaspoon at the start of the day.
 
Ketamine and other drugs like it have been shown to have several interesting properties...in animals.
Increasing the effects of a given dose of opiate.
Slowing the development of tolerance to a repeatedly given dose of opiate.
Prolonging analgesic effects of a given dose of opiate.

I should also add in the interest of HR, that in humans taking opiates and ketamine as a combination significantly increases the risk of unconsciousness and vomiting...which could cause suffocation.
 
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NO2 stimulates opioid receptors, and ketamine may influence them indirectly. Either way, dissociative drugs are good for opioid w/d all around. Probably due to the euphoric/analgesic effects.
 
thanks, makes sense. Starting to build a clearer picture of how many drugs have multiple mechanisms of action.

I forgot I had about 200+ cannisters of NOS, never thought I would touch them again. But now I understand if you consume enough oxygen alongside them it's safer etc (I found that I used them so much at festivals in UK that they just made me nauseous and had uncomfortable associations with them, probably due to the predominant method of hyperventilating them with a balloon, or my method which also included no oxygen intake alongside inhalation).

so, in theory using a few cannisters a day could be quite helpful during a kratom or opiate detox? Or is the short duration of action just going to only give me temporary relief?
 
Nitrous oxide isn't going to be much help during opioid WD because it only lasts for a minute or so, unless you want to be hooked up to the source for the whole duration of the withdrawal that is.
 
yeah agreed. I think I will use them for temporary relief.

I find ketamine is nearly as temporary too, so in theory one could cautiously alternate for an hour on low doses for temporary relief, as well as getting some of that NMDA action....


I think the agmatine deserves more of a mention too. Taking it today it's surprising how it makes me feel with bit of coffee and some rhodioloa.

Agmatine has NO properties I think? Would that synergise with NOS intake or perhaps create some sort of a risk?
 
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