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  • TDS Moderators: AlphaMethylPhenyl | paranoid android

ketamine as an AD

theartofwar

theartofwar

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Jul 29, 2009
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http://www.sciencedaily.com/releases/2010/08/100819141913.htm

^one of my best friends and fellow bl'er showed me this.

Now i know ketamine leaves me with what i used to think was a longgg afterglow - but i heard about the AD side - now reading this. I think I will try in at around 250mg once a week - I am so fuckng depressed although this episode i believe is moving out and I am doing what I can. I'll folow up on how itworks;

btw tried tons of ssri's n snris
 
I wouldn't knock it as a legit treatment for major and bipolar depression that is treatment resistant to the typical drugs used. Also since many people such as me are pretty limited in what they can take for the depression side of things the more anti-depressants out there the better. We can't all get along well with SSRI's and SNRI's :p . They work for some but most anti-d's that touch serotonin drive me crazy hence why i am on bupropion.

If you have trouble controlling your use of ketamine i would maybe suggest against this though. Overuse of ket would most likely make your brain feel even more messed up.
 
from what ive read the problem lays in how fast your tolerance raises and dealing with that in the long run(plus the usual side effects).. some physical side effects due to long term usage etc... iirc there was a thread on dissociative drugs being used as anxiolytics/AD in ADD.
 
I don't know if he's the source for this, but Jamshyd knows a thing or seven about this particular topic. I can't comment much on it, as I've barely read up on it, but it seems promising. Synaptogenisis indeed!
 
Ketamine is an excellent anti-depressant. I get an afterglow from one dosage which lasts for months.

The key is to use it only when necessary and to ride out the afterglow for as long as possible. As stated above, overusage of ketamine isn't going to be pleasant.
 
what i find interesting in this article is that it says that ketamine can heal the brain damage caused by stress even at low doses and weekly use. i guess they are talking about the synaptogenesis?

also, i like how this article pointed out mTOR is the enzyme possibly responsibly for the rapid, antidepressant qualities of ketamine.

two days ago, another article came out: http://psychcentral.com/news/2011/06/20/a-drug-with-rapid-antidepressant-effects/27073.html

but this one was not as informative.
 
i have found it gave me instant relief, and helped me out for a few hours; few hours of inner peace and clean fresh mind with no worries
Then it all came back then =(
But i did a lot of it.

I think as others are saying a lower dose could be helpful , hope it helps you
 
In the past when using ketamine the anxiolytic/AD "afterglow" was apparent as hell, and i have always wanted to use it purely to obtain those effects. not that i haven't tried.. ended up bad for a couple of reasons (because im a drug addict and have problems not indulging, not a cheap habit to maintain). would love to hear from someone who has successfully utilized ketamine as an antidepressant long term.
 
Gzz I've been holding onto a couple gms for over a year now I really hate ketamine lol. I know that "afterglow" you guys are talking about but it seems like a detached kinda of afterglow. To me lights will seem a little brighter, and I will feel ok with things. Buts its definitely not a clean type of antidepressant effect imo. In fact the glow I get is really dirty, I do not like it whatsoever. Even low doses (like a speck of ket not even a bumps worth) makes me feel all fuzzy headed and detached. Then when it wears off it just feels less intense.

As far as feeling it for weeks afterwards though thats extremely odd. I mean by the second day I usually go right back to my regular self. I know ketamine increases a certain neurotransmitter and its apparently suppose to reduce opiate tolerance but I dont know the drug is just too sloppy and intense at any dose. Even when the effects are weak I don't really enjoy it. Would think low doses of mdma would make a much better anti-d. Ketamines glow seems more like a hangover.

Oh and I have kanna leaf I imported from africa (the legit strain) and if you wanna talk about "afterglows" that shit will give you a clean, clear and very potent glow. It also produces empathy and emotions kinda like opiate do very nice feelings and no wds at any point no matter how much you use. So I'd personally say kanna would be a way stronger anti-d than ket. Just my opinion.
 
http://forums.phoenixrising.me/attachment.php?attachmentid=2541&d=1274191474

This is a very thorough research paper about the benefits of ketamine. I'm pasting just a few things. It's kind of the everything u'd want to know about the therapeutic uses of ketamine on humans.

[Major revision to be added: weekly dosing can result in tolerance; best option for depression is prolonged subanesthetic dose infusion monthly, rather than short-course infusion weekly, so as to minimize likelihood of tolerance.]

This is the Table of Contents:

The Clinical Evidence [for ketamine] – 2
A. Refractory depression – 2
B. Refractory fibromyalgia – 4
C. Refractory chronic regional pain syndrome – 8
D. Case reports in other psychiatric and neurodegenerative disorders – 11
E. Dosing – 11
Part III. Pathogenicity in Advanced Lyme Disease – 11
A. Inflammation – 11
B. Kynurenine pathway-mediated excitotoxicity and oxidative stress – 13
Part IV. IDO/kynurenine pathway-mediated immune dysregulation – 15
A. Simplified and selective overview of some key components in adaptive immune response – 15
B. HIV- and cancer-like immunosuppression by overactivation of IDO and kynurenine pathway – 16
C. Role of IDO and kynurenine pathway in autoimmunity – 18
D. Risks of suppressing TNF-alpha and IDO – 19
Part V. Ketamine’s mechanisms of action – 20
A. Anti-inflammatory effects and neuroprotective mechanisms in excitotoxicity and oxidative stress – 20
B. Likelihood of reducing immunosuppression and possibility of terminating autoimmunity in advanced Lyme disease – 21
Part VI. Low-dose ketamine safety profile – 21
A. Side-effects – 21
B. Tolerance and addiction – 21
C. Neurotoxicity – 22
D. Effects of long-term treatment with low-dose ketamine – 22
E. Drug-drug interactions – 22
Part VII. Conclusion – 22
Figure 1. The kynurenine pathway – 24
Table 1. Inducers of IDO – 28
References – 29
 
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