• Neuroscience & Pharmacology Discussion Welcome Guest
    Posting Rules Bluelight Rules
    Recent Journal Articles Chemistry Mega-Thread
    FREE Chemistry Databases! Self-Education Guide

  • N&PD Moderators: Skorpio

(+)-Ketamine - another MDA?

I once had a dream in which pure S-ketamine synthesized by Sigma-Aldrich was obtained. It's certainly more potent than its racemic counterpart, I'd say in the order of 1.5-2.5x as potent per weight.

Qualitatively, the effects were quiet different as well. It's hard to properly relate to racemic, as I was constantly doing 'more' than I ment to do as a result of the increased potency. Onset seemed much more rapid, it was zero to peak in under 5 min (intranasal), compared to racemic which takes close to 10min in my experience.

It was never calm and progressed with much more 'drive' or 'force' than racemic. No time was spent in analytical thought; I would spend the entire experience trying to collect the shattered pieces of my mind, try and get some bearing/orientation, etc. Everything had a 'Woah this is out of control' feel, and by the time I got a handle on it, the experience was fading.

Also (subjectively) the S-enantiomer was a much better opiate potentiator than racemic.

What a strange dream.
 
I'm curious about an 'adderall' type preperation of ketamine isomers. I'm thinking 50% racemate and 50% S-ketamine.

I'm going to try this very soon.
 
My cat's uncle's poodle once procured some s-isomer from Germany, which I think it's referenced to by Karl Jansen's Ketamine book "K". The high was more psychedelic in quality and the recovery was a matter of a couple of minutes, unlike racemic which can seem to linger, hence the "tard" feeling. :)

specialr
 
The S Ket is more trippy, I think. I find it more social, Being able to take it with people I dont really know without the worry off going off on an episode. I find it more nice and gentle, Although I always end up having some racemic when i am back home. The jury is still out on which is the best.
 
I think I side with the racemic version personally. S+ It IS nice and good but lacks a certain somthing.
 
Someone help me out with nomenclature here please.

What is the ketamine that is usually available? Is that the R isomer? I've had plenty of dissociative ketamine and always enjoyed it bar for the fact that it would take me ages to come back into my body properly after the experience.

I've just had the chance to try to S isomer for the first time, at a low dose (25mg nasal). WOW. Comparable to the other one but this doesn't in any way feel like dying, it isn't really dissociative. Just a great moodlift and some perceptual 'funny stuff' and slowing me down just a little, making me calmer. I enjoyed this a fair bit. Compatible with being sociable, and even with a beer or two and with abundant amounts of food less 3-4 hours later. I could eat this daily but I guess I won't. Just wondering how long the moodlift lasts if I don't redose this unnecessarily. Days?

Until today the anti-depressant fx of k were never really obvious to me
 
Ximot said:
Someone help me out with nomenclature here please.

What is the ketamine that is usually available? Is that the R isomer?
Click to expand...

Regular ol' ketamine is racemic (50% r, 50% s)
 
/\ so, having just the R-isomer should be an incredibly dissociative experience? Like, more so than havign the mix?
 
morninggloryseed said:
I'm curious about an 'adderall' type preperation of ketamine isomers. I'm thinking 50% racemate and 50% S-ketamine.

I'm going to try this very soon.
Click to expand...


I've tried 50mg of racemic dried vial ketamine and 100mg of pure S isomer Ketamine in one line before. It just lead to pure retardation but many crazy visuals. I was coming down off a fair few drugs at the time though, including lots of MDMA, speed and 2C-B and 5-meo-Dipt, 5 neo doves, along with a very weird pill with very slight MD (and some very odd substance that was psychedelic, almost felt like a low dose of DMT and lasted a very short time, those intense muscle and eye wobbles you get all synchronsiing with visuals, the world you see around you turning into something very alien..) Anyway on the comedown of this cocktail I did the Ketamine mix, after smoking a few pipes of weed, then hit the nitrous (~80 bulbs)... Was a pretty weird experience... But I've tried similar cocktails before with the weed, ket, and n2o on the comedown but this K mix was somethinh diofferent... way too retarded but yes, very visual.

The Pure S isomer is grand. Feels a lot cleaner and more psychedelic, almost like a new drug. Takes a little longer to fully kick in, but lasts longer too.
 
Ximot said:
/\ so, having just the R-isomer should be an incredibly dissociative experience? Like, more so than havign the mix?
Click to expand...

Less breathing troubles, but just more pure anaesthetic. mild visuals and more DXM and sedated like i would believe. S isomer seems like it has energy to it.
 
anyone combined ketamine with speed (amphetamine) ?

I am considering combining the S isomer with a small amount of amphetamine for a day out as the S isomer alone might make me feel a little wobbly after all.
 
You end up with a lot of sympathetic NS activity, but if you're OK with that, then as long as you don't take silly doses your body will not rebel. Watch out for overheating though because the sympathetic activity raises your temp slightly
 
You must log in or register to reply here.
Top