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Kanna's effect on psychedelics and empathogens

《Plasticity》

《Plasticity》

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I'm not quite sure whether to post this in PD or ED but since I use psychedelics more frequently I'll go ahead and post this here. I'm also aware that this post may not get many replies due to the fact that it's a pretty specific question. Anyways... lately I've been reading about kanna and it seems like exactly what I'm looking for, a nice mellow mood booster that I can snuff as needed however since it supposably works as an SSRI does this mean that if I add kanna to my regimine I should expect a decrease in effects when tripping or rolling? If so can this be avoided by simply not taking kanna the day of the experience? I'm also aware that mixing it with monoamine releasers can be dangerous but how about with psychedelics? If kanna dulls the effects of monoamine releasers or psychedelics I will reconsider adding it to my regimine as I'm not necessarily depressed, just "blue" on some days, perhaps kanna may even prove to be an effective comedown remedy for rolls on the days after that leave me feeling empty.

TL;DR - Basically I'm just looking for someone who takes kanna regularly and their experience on how it affects their serotonergic drug use.
 
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Hmmm, I am assuming you are talking about Kava when you say Kanna, I have no idea how you would snuff this unless you have some weird extract... I highly advise against daily use. Kava it is own right is amazing but detrimental to the liver, I recommend it once a week tops but be careful this shit is way hard on your liver some sites and people will try to tell you other wise but trust me, daily use can lead to liver failure plain and simple.

I am not 100% briefed on the pharmacology, binding sites, method of action etc.. pertaining to Kava, however I have taken it tripping and I feel it makes for a more powerful trip kind of like a potentiator that is just my own experience.

Kava is awesome to take a large dose once in a rare while and kick back WITH NO ALCOHOL, I feel like I'm on a beach in Hawaii. However that is really the only thing it should be used for, precisely what the traditional use is for. A social gathering with just Kava no booze or other drugs on rare occasions, it can be awesome when used correctly
 
Definately reffering to kanna (Sceletium Tortuosum), lol you couldn't pay me to rail any amount of kava. Also I think the whole kava causes liver damage rumor is still debated, this originated from some mainstream company using the leaves and foliage which actually are detrimental to your liver, legit kava is supposed made from the rootbark only. As expected this thread is a wasteland, if anybody has some info on this subject It would be greatly appreciated.
 
Now this odd combination I actually have experience with. Way back in the day I read about how SSRI's help with an MDMA comedown so out of experiment's sake I added Kanna to a botanical order I was making otherwise.

I had an MDMA experience and on the comedown I smoked a little bowl of it. Instantly it alleviated a good deal of negative effects... BUT it sure didn't last long; maybe half an hour. At that point the negative anxiety came back much worse than it's previous level.

The effects don't last long enough and the instant SSRI withdrawal in the midst of an MDMA comedown blows something fierce. Your mileage may vary, but the information to take from my experience is the fact that I'll never do it again.
 
Be aware that mixing SSRI's and psychedelics is a notoriously unpredictable business, even if it is not immediately very dangerous.
 
Be very careful with combining Kanna with psychedelics. I have had a serotonin syndrome type reaction on 2 different occasions from carelessly adding some kanna to whatever i was on at the time. Never again. Be especially wary of combining with serotonin releasers and nmda antagonists.
 
I definately never planned on mixing the kanna with anything besides kratom, I'm well aware of the dangers when mixing SSRI's with empathogens and psychedelics. It is good to know that kanna's SSRI effects are strong enough to cause complications though. Basically my main question is that because pharmaceutical SSRI's cause a blocking effect on psychedelics does this mean kanna will do the same if I take it every day except for the days that I plan on rolling or tripping (perhaps stopping kanna 3 days before use would be safer?) or is this "blocking" phenomena due to traditional SSRI's causing downregulation? AFAIK kanna doesn't cause downregulation or rebound effects therefor kanna shouldn't really dull the effects of psychedelics or monoamine releasers right?
 
I would think it will. If it alleviates MDMA anxiety (albeit very temporarily), it's exhibiting typical SSRI action. The rebound effect is very aparent (as I explained). It's blocking serotonin reuptake, but the half life is so short. So it likely would attenuate psychedelia, but not for long.

If you don't take Kanna the day of the trip I would imagine it would have no effect at all.
 
iirc, I'm pretty sure that the half life of kanna is relatively short, like 4 to 6 hours or something. I have read that it dulls 5ht2a trips by a fair bit, but i have not experienced this personally, for obvious reasons. :)
 
Thanks guys, that's what I was looking for. By rebound effects I mean taking it daily and abrubtly quitting causing short periods depression and anxiety issues that are apparent with traditional SSRI's which is indicative of downregulation. I couldn't find any reports of such things occuring with even high doses of kanna over long periods of time, this may be due to it's incredibly short halflife. If avoiding kanna on the day of the trip or roll is sufficient enough to not have any sort of blocking effect then I would be more comfortable taking it with any regularity.
 
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Well, I can't really speak to kanna very much personally, but yeah, I'm fairly certain that the only reason regular SSRI use blunts the effects of psychedelics is from 5-HT2A downregulation. So if you can find some conclusive evidence on that for kanna you should have your answer.
 
No they're not, not at all. Kanna is sceletium tortuosum, and kratom is mitragyna speciosa.

I don't like kanna. I got a small sample of it from my old kratom vendor and I tried sniffling a small bit of it. I remember I got all hot and felt weird and anxious. I left it in my freezer for years. Then a few months ago I was feeling super depressed one day and I tried it again. Same thing. It made me feel really bad, very uncomfortable and hot and racing. I couldn't wait for it to be over - fortunately it's very short.
 
Turns out kanna wasn't for me either, it reminded me of the ssri aspects of tramadol... not very pleasant. Glad I only ordered a gram of the extract as it's something I'll likely never try again.
 
Yeah it is tramadol-esque, not in its entirety but the weird, SSRI-like parts. I hadn't thought of that. Sounds like you and I are similar in terms of kanna. No thanks for me, very weird-feeling. Feels bad for me even at tiny doses. I never used any extract, just the ground raw herb, and I did a teeny tiny line, couldn't have been more than 50mg.
 
Exactly, not something I would want in a depressed state lol. It was like taking all the good parts out of tramadol and leaving me with the jittery anxiogenic parts. I was surprised because of all the positive reviews... Was anything but positive for me.
 
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