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  • BDD Moderators: Keif’ Richards

JWH health risks?

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no one? i'm curious too. you always hear people/the news saying how bad it is or it causes cancer lol..but of course they aren't gonna tell you its safe even if it was safe
 
I recently smoked Spice for the first time and was wondering about this myself. There have been a few deaths, but nothing conclusive about the cause. No telling how much of the stuff contains badly synthed JWH and what the effects of that could be.
 
ive tried it a few times, I doubt I'll ever try it again until some more research is done. Just because people are smoking it and not showing neg reactions isn't enough proof for me, people smoke cigarette for years with no apparent negative reaction, then one day they get cancer.
 
People also understand that nicotine, polonium-210, lead-210, etc. are carcinogenic as well. They understand not only that it causes cancer, but they specifically understand how it interacts with DNA to cause the genotoxicity.

So far the only published research on JWH-018 has shown it to not have this kind of genotoxic property. Other JWH-* of the series like JWH-015 and JWH-133 on the other hand have research explaining a mechanism of action for their causing the PREVENTION of cancer.
 
Well, of course it effects the nervous system. It's a full agonist at CB1 and CB2 receptors, and probably has effects on many other receptors like the trace amine receptor, GPR55, TRPV1, etc. It indirectly modulates GABA transmission and the opioid system via the CB1 agonism in the brain.

It causes receptor downregulation and development of tolerance/addiction to an even worse degree than THC can also.
 
Coolio said:
People also understand that nicotine, polonium-210, lead-210, etc. are carcinogenic as well. They understand not only that it causes cancer, but they specifically understand how it interacts with DNA to cause the genotoxicity.

So far the only published research on JWH-018 has shown it to not have this kind of genotoxic property. Other JWH-* of the series like JWH-015 and JWH-133 on the other hand have research explaining a mechanism of action for their causing the PREVENTION of cancer.
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Nicotine has not been shown to be carcinogenic on it's own, outside of smoking/other tobacco use. It's likely that it plays some contributory role by inhibiting apoptosis, though.
 
Coolio said:
Nicotine has been shown to be genotoxic on its own.

http://toxsci.oxfordjournals.org/content/86/2/309.full for just one example out of dozens or hundreds.
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Genotoxic ≠ carcinogenic (necessarily.) The body has some pretty neat checks and balances for DNA repair and damage prevention.

If you'll finish reading the abstract of the article you linked, they mentioned that they observed targeted genotoxicity in vitro, but no difference in DNA damage in cells from smokers and non-smokers.

The lack of higher DNA damage in smokers compared to nonsmokers could be a question of nicotine dose, rapid DNA repair, or interactions with other smoke constituents. These results require further investigations on the contribution of nicotine to tobacco carcinogenesis.
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I'm just talking about the mechanism of action being known I guess. There's no proposed mechanism of action with JWH-018 that would cause it to interfere with DNA replication.
 
Coolio said:
I'm just talking about the mechanism of action being known I guess. There's no proposed mechanism of action with JWH-018 that would cause it to interfere with DNA replication.
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Definitely, I didn't mean to hijack the thread! But I totally agree, there isn't any known mechanism for the JWH drugs.
 
Coolio said:
Well, of course it effects the nervous system. It's a full agonist at CB1 and CB2 receptors, and probably has effects on many other receptors like the trace amine receptor, GPR55, TRPV1, etc. It indirectly modulates GABA transmission and the opioid system via the CB1 agonism in the brain.

It causes receptor downregulation and development of tolerance/addiction to an even worse degree than THC can also.
Click to expand...

so this does what in the long run?
 
Basically, one Canadian study found that one type of JWH (not 018 or 073) might be carcinogenic. Otherwise, on the contrary, JWH seems in general to be anti-inflammatory, anti-carcinogenic and may hinder the development of Alzheimers. Good or bad, not enough research has been done on these substances.
 
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