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Just curious: 1-(1-phenylpropan-2-yl)pyrrolidine (Scraps about α-PPP)

B

boohigh

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Nov 5, 2008
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Hello, Everybody. If anyone knows about this compound:
t127350_ampam.PNG


Would it be a stimulant, maybe someone bioassaed it?
 
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Definitely would have stimulant effects, probably most similar to prolintane:

220px-Prolintane.svg.png


I wonder if a para-fluoro group on the phenyl ring would improve potency?
 
why do we never heard about compound i mentioned. It's bete-ketone cousin is very speedy( IV Rush is pretty strong ~150-200mg). Would it be more euphoric than regular amphetamine, or not?
 
Doubtful. That's not very potent for IV use. Do we call it prolintanone then?
 
I have heard of it called alpha-PPP. I anticipate that it is a DAT inhibitor rather than a proper substrate, as the pyrrolidyl ring is too bulky to allow it to be translocated--so it should be feel kind of like methylphenidate or propylamphetamine.

Edit: Oops, the beta-keto analogue is alpha-PPP. I guess this would be pyrrolidylamphetamine. I bet that it feels a lot like propylamphetamine...very mild, not too much oomph. A lot of people seem to like the mild stimulation of propylamphetamine, though. I take dextroamphetamine every day, so it is a little on the weak side for my tastes, but for anyone that doesn't want a balls-to-the-wall stimulant, it seems enjoyable.
 
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Heh, yeah, I've had alpha-PPP. I've written about it here somewhere. I loved it actually. Better than 90% of these new stimulants. It kills any of these cathinones in terms of euphoria.
 
a-ppp is really shit drug, it has hellish come down with tremor and very sad feelings. I used a-PPP for about year. The only good side is a RUSH from a 150-200mg IV, that's killer rush in terms of euphoria, but come down is shit. Very fiendy, you don't stop until it's gone. 2g+ can be easily done in 24 hours until you start to realize that there's no rush and the next dose may make it even worse.
But that pyrrolydin-amphetamine is interesting, by the way.
I's love to see more comments on it )


Hammilton said:
Heh, yeah, I've had alpha-PPP. I've written about it here somewhere. I loved it actually. Better than 90% of these new stimulants. It kills any of these cathinones in terms of euphoria.
Click to expand...
 
btw, a-PPP is metabolised to cathinone in your body. That's why we had so shitty comedown.
 
Ham: I remember your description of alpha-PPP--made me jealous...one of those rarities that I would love to try. I wonder if pyrrolidylamphetamine would be better than the beta-keto alpha-PPP?

I can't see how alpha-PPP would be metabolized to cathinone in vivo. I don't think that the liver would try to remove that entire pyrrolidyl moiety. I'm betting the metabolites are the beta-hydroxy and ring hydroxylated species.

I like the name ampyrrodine though.
 
Damn, I totally stand corrected. Good show.

If norephedrine is formed in any significant quantity (they mentioned it as a metabolite, as it is also a metabolite of cathinone), that could be responsible for peripheral annoyances and a lingering general 'tweaky' nastiness. The amphetamine wouldn't have that problem, so it might indeed be smoother.
 
I'm not entirely sure that cathinone will be present at very high levels. Prolintane is metabolized to "ring opened metabolites" which I assume would be N,N-diethyl-propylphetamine, as well as beta-oxo (keto)-derivatives. Well, actually, it doesn't say where the keto is, but I would assume it's on the beta carbon, no others make sense in this case.

Abstract

1. The metabolism of prolintane in vivo has been investigated in rats; the pharmacological effects in mice of the metabolites from rats and rabbits have been examined.

2. In four rats receiving [3H]prolintane (50 mg/kg, intraperitoneal) about 57% of the radioactivity was excreted in the 48 h urine.

3. A pyrrolidine ring-opened metabolite (15% dose) and p-hydroxyprolintane (5% dose) were excreted as predominant metabolites together with traces of unchanged drug and oxoprolintane.

4. The general activities (ambulation and rearing) of mice were increased significantly by p-hydroxyprolintane and (ω — 1)-hydroxyprolintane as well as prolintane. Oxoprolintane was not effective on ambulation, but partially effective on rearing. However, PPGABA showed a depressant effect in mice rather than being stimulatory.
Click to expand...

Interesting that oxoprolintane is being described as ineffective at increasing abulation. What exactly is meant by "(ω — 1)-hydroxyprolintane" though? What is PPGABA? I can't imagine prolintane being metabolized to a GABA derivative, though it would be rather interesting, and that's what this seems to say. I think that this would answer my question: http://www3.interscience.wiley.com/journal/119838985/abstract?CRETRY=1&SRETRY=0

Since the amphetamine derivative is likely to also share the oxo metabolite, it's probably going to have the same problem.
 
With dosage around ~200mg in time it may be nasty even if it's metabolised to cathinone->PPA in minute amounts.
Thanks god i'm not a young woman who may expierence stroke from PPA =D
 
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