Okay I have been doing some reading and from what I can tell, Jurnista tablets use the "Push Pull" OROS method of reverse osmosis as antiabuse (and, in theory, to last longer) same as Concerta. To clarify, Jurnista is a drug that was not available in the US and as of March 1, 2010, the FDA approved it under the trade name Exalgo by Mallinckrodt (rights were purchased June 2009 so the drug companies have known about this for a while -- perhaps therefore the antiabuse will be/is different from that of Concerta? Perhaps even Exalgo is different from Jurnista?
On the official website for information about this drug as Jurnista, (I'm not going to bother with citations for now but can later if anyone is interested) it literally said that the pill would pass through the bowels intact and that was not to be worried about because "there was no more of the chemical left" (paraphrasing).
On the megathread, http://www.bluelight.ru/vb/showthread.php?t=482108 bluelighters claim the bioavailability -- of probably the non XR / 24 hr variant, was ~33% oral ~55% intranasal 60 - 90% (?) plugging and ofc IV would in theory be 100%. I have seen other figures where people claim oral to be higher bioavailability than sniffing, but never is it clear whether or not the topic was of any particular formulation.
I have come into some what I thought were 4 mg hydromorphone IR's actually 8mg Jurnista's (unless the pills are fake but I have no reason to think that). I used to have opioid issues but recently have been forced off methadone and am looking for a new physiatrist (pain specialist as opposed to just an MD), methadone for pain mind you. I therefore want to keep my tolerance as low as it is now but want to get the most of my pills. I know sniffing pills is bad but cost is a factor here as well and I think I have the willpower to keep from going through an entire pill at once. Basically my left shoulder stretching down and to my neck / underarm is unusable and the pain cream I get with 5% lidocaine 10% ketamine 15% ketaproufen is hard to administer and its effect only goes so far. My right arm also has nerve pain issues and I am on 450mgs Lyrica/day tapering off klonopin down from 4mgs/day to 1.5 and have been using so much damn tylenol and aleve that I think I have affected my stomach and liver both. I cannot explain why exactly but my stomach feels very fked up from overusing 500 mg naproxen tablets and I have had more than 4000mgs aceta./day a couple times -- not intentionally but in retrospect I realize. My PCP knows very little but we are establishing a degree of trust now that he has seen me off of methadone and is offering me a referral to the physiatrist of my choice. I don't know how to describe the symptoms of my stomach/liver but I was told once that lyrica combined with aceta. is also quite hard on the liver.
That said, how can I with no needles get the most of my pills? I presume crushing will be extraordinarily hard and I don't have a mortar/pestal and as I understand it that may not help me in the end anyway as when I was prescribed 10mgs oxycodone every three hours I would crush and parachute quite frequently with my stepfather's mortar/pestal and so much powder is lost in the process. Granted these were 5mg pills totalling 70mg oxycodone/day but I know how to crush oxy reasonably well (old formulation) and can only imagine disastrous results.
Would sniffing have a greater bioavailability in the case of the XR variant? Would parachuting work? Should I just try one orally and see how that works for me -- though I am afraid I will inadvertently lose some of my pills this method and hence am asking here first.
I repeat no needles, I just want the most bioavailibilty I can get. I would plug if it were not seemingly totally fruitless with this alternative method of the pill working orally. Also I mention my stomach/liver in case sniffing is harder on the liver (as it then bypasses the first round, can't remember the proper terminology at the moment, hepaptic bypass or something of that nature) or if it would be harder on my stomach (I think I have been experiencing minor stomach bleeding that if I continue with the overuse, not intentionally just taking it without thinking with probably not enough food, doubtful but possible I may have an ulcer) to take orally?
I realize this is a rather complicated question but I just want to get some functionality back so that I can go about cleaning my apartment up and finding a doctor. I am so totally helpless to the pain that I can honestly say I think I need narcotic pain relief at the moment but the system is totally screwing me in that regard no questions asked. I don't want to hurt myself either inadvertantly.
Thanks.
On the official website for information about this drug as Jurnista, (I'm not going to bother with citations for now but can later if anyone is interested) it literally said that the pill would pass through the bowels intact and that was not to be worried about because "there was no more of the chemical left" (paraphrasing).
On the megathread, http://www.bluelight.ru/vb/showthread.php?t=482108 bluelighters claim the bioavailability -- of probably the non XR / 24 hr variant, was ~33% oral ~55% intranasal 60 - 90% (?) plugging and ofc IV would in theory be 100%. I have seen other figures where people claim oral to be higher bioavailability than sniffing, but never is it clear whether or not the topic was of any particular formulation.
I have come into some what I thought were 4 mg hydromorphone IR's actually 8mg Jurnista's (unless the pills are fake but I have no reason to think that). I used to have opioid issues but recently have been forced off methadone and am looking for a new physiatrist (pain specialist as opposed to just an MD), methadone for pain mind you. I therefore want to keep my tolerance as low as it is now but want to get the most of my pills. I know sniffing pills is bad but cost is a factor here as well and I think I have the willpower to keep from going through an entire pill at once. Basically my left shoulder stretching down and to my neck / underarm is unusable and the pain cream I get with 5% lidocaine 10% ketamine 15% ketaproufen is hard to administer and its effect only goes so far. My right arm also has nerve pain issues and I am on 450mgs Lyrica/day tapering off klonopin down from 4mgs/day to 1.5 and have been using so much damn tylenol and aleve that I think I have affected my stomach and liver both. I cannot explain why exactly but my stomach feels very fked up from overusing 500 mg naproxen tablets and I have had more than 4000mgs aceta./day a couple times -- not intentionally but in retrospect I realize. My PCP knows very little but we are establishing a degree of trust now that he has seen me off of methadone and is offering me a referral to the physiatrist of my choice. I don't know how to describe the symptoms of my stomach/liver but I was told once that lyrica combined with aceta. is also quite hard on the liver.
That said, how can I with no needles get the most of my pills? I presume crushing will be extraordinarily hard and I don't have a mortar/pestal and as I understand it that may not help me in the end anyway as when I was prescribed 10mgs oxycodone every three hours I would crush and parachute quite frequently with my stepfather's mortar/pestal and so much powder is lost in the process. Granted these were 5mg pills totalling 70mg oxycodone/day but I know how to crush oxy reasonably well (old formulation) and can only imagine disastrous results.
Would sniffing have a greater bioavailability in the case of the XR variant? Would parachuting work? Should I just try one orally and see how that works for me -- though I am afraid I will inadvertently lose some of my pills this method and hence am asking here first.
I repeat no needles, I just want the most bioavailibilty I can get. I would plug if it were not seemingly totally fruitless with this alternative method of the pill working orally. Also I mention my stomach/liver in case sniffing is harder on the liver (as it then bypasses the first round, can't remember the proper terminology at the moment, hepaptic bypass or something of that nature) or if it would be harder on my stomach (I think I have been experiencing minor stomach bleeding that if I continue with the overuse, not intentionally just taking it without thinking with probably not enough food, doubtful but possible I may have an ulcer) to take orally?
I realize this is a rather complicated question but I just want to get some functionality back so that I can go about cleaning my apartment up and finding a doctor. I am so totally helpless to the pain that I can honestly say I think I need narcotic pain relief at the moment but the system is totally screwing me in that regard no questions asked. I don't want to hurt myself either inadvertantly.
Thanks.
