IV Midazolam - VERY Dissapointing!

[DexyDevil]

Hello,

I'm autistic and sometimes I have episodes of extreme anxiety, rage and self-injurious behavior known as "meltdowns." Occasionally a trip to the ER becomes mandatory.

Two days ago I wound up at the ER where I was adminstered 8mg of Midazolam IV over a 30 minute period. The first two mgs felt like pure salien. The next two had a mildly calming effect but I was still violently agitated. Then 4mg were delivered all at once and I became relatively tranquil... but that's it! I experienced less of a rush than I have with IV lorazepam. It felt about as as potent and euphoric as diphenhydramine.

What's up? I thought IV Versed was supposedly the pinnacle of the benzo experience. I get more inebriation from a couple mgs of Alprazolam.

Did I miss something? What was I supposed to experience that I did not and why?

 

[tentram]

i thought IV/IM midazolam was a bit of a letdown at the time i acquired a few ampoules of it -admittedly i was already quite tolerant to benzos. it was still a nice experience but nothing i don't get out of valium, personally. it was just the novelty of injecting a pure amp - something you don't come across outside a hospital setting too often.

you'll probably find as it was infused over a long(er) period of time it would have been perceived as diminished effects. all at once is going to equal a bigger "hit" rather than through a 30min infusion.

do you have a standing benzo tolerance

 

[effie]

Experiences can vary hugely, and often don't live up to the hype. Perhaps in your state of high agitation the midazolam was enough to do it's job but nothing else.

I was given IV midazolam before a procedure and all I really got was slight relaxation then amnesia.

IVing midazolam can be very dangerous and is best left to the professionals really. It's a shame it didn't float your boat, but on the other hand it sounds like it did it's job and provided anxiolysis.

I can't see any HR value in this thread so I am going to close it. If you want to write up your experience, feel free to use the Trip Reports forum

Closed, PM me with any queries.