RCs Isopropylphenidate (IPH, iPPH)

[Sun42shyne0]

Quick question: Can you IV this our is it as nasty as MPH?

You can but it isn't worth it really, "rush" only last 2mins. And then you pretty much just feel like your coming down after 30mins.
IV 25 mg first time using it. Mild rush light clean stimulation. Made me want more instantly did another 35mg same thing slightly more rush very mild, more stimulation mind you this is 20mins after the first dose. Again compulsive redose urges. 20 mins later intranasal 45mgs. 20mns after that slight euphoria kicks in and lasts 1hr stimulation was strong but not uncomfortable, though it was too much to accomplish any work. 2hrs later IV 40mg slight rush again but not worth it really, because again I felt a compulsion to do it again. But I refrained with little to no struggle. Overall effects lasted an additional 4hrs.
Like everyone has said it has high value as a functional stim. But little to no recreational worth, though it might pair nicely with other drugs like ketamine or opiates.

 

[negrogesic]

I find the binding affinity data for 4F-MPH to be... misleading. I would be surprised if you preferred it to Rita if using it for recreation. Unless you have a GABAergic sedative on hand, pushing dosages past ~20mg is quite uncomfortable (in my experience). Positive effects seem to stop increasing past that point and it turns into body load, nausea, and dysphoria. Mostly body load, though.

That being said: 4-12mg of it makes for a GREAT functional stim; take it before work, good to go until end of shift.
For 2-4 hours you get a surprisingly pleasant psychological uplift; this is followed by a one hour mini-crash, which in turn is proceeded by 4-8 hours of physical stimulation. The psychological effects begin to diminish by the 4 hour mark, though; redosing at this point seems to just build up the physiological stimulation without re-upping any euphoria.

Very useful, though; I'll take some before heading out to a concert (pre-COVID) and have energy to dance the night away, or, when I worked labour, before a long day of hauling furniture if I wanted the day to fly by and not brutalize me.

If trying to use recreationally, it pairs well with alcohol. From what I've read, conversion to 4F-EPH is present but not clinically significant. The body load/dysphoria are barely noticeable if you coadminister something relaxing, leaving you able to feel only the positive effects of 4F-MPH.

By itself, though, make sure to titrate dosage upwards and dose volumetrically; a few milligrams too much turns 6-10 hours of feeling good/getting shit done into 6-10 hours of I Have Made A Mistake Ughhh



Ps- I love that Ritalin is named after the Italian creator's wife; she couldn't play tennis due to some sort of chronic ailment, but Ritalin helped her function normally. Her name was Rita.

Definitely agree here, as a former MPH connoisseur of sorts i found 4F-MPH disappointingly non-recreational in comparison. Pretty therapeutic however. In some ways its probably more clinically effective. But only perhaps 1/4 as recreational.

However i will say the binding data is right and in fact its precisely because of its higher blockade of the dopamine transporter that makes it less recreational. Excessive dopaminergic activity relative to norepinephrine reduces abuse potential. The highly specific DRI's are no fun.

In my experience 4F-MPH is to MPH as 2-FMA is to Methamphetamine, greatly reduced abuse potential and in some regards, increased functional potential.

 

[Longitudes]

Anyone have any recommendations on suppliers in the USA for IPH, 4F-MPH, or EPH?

 

[Dextro .45]

MPH / EPH / IPH ….all 3 Phenidates have been extensively studied in medical journal studies

IPH Isopropylphenidate was/is a compound with promising attributes and was extensively studied for its application in treating ADHD, and other therapeutic usages in Canada

Ritalin (Methylphenidate) considered a “Classice Amphetamine” in numerous medical literature as is very unique MOA isn’t a straight forward DNRI (such as Bupropion/Wellbutrin). Ritalin (Methylphenidate) is nearly identical to Cocaine in its MOA, both being classified as “Inverse Agonists” and the 2 compounds both compete for the same binding sites inside the mammalian CNS DAT in regions responsible for pleasure & reward

Ritalin (Methylphenidate) is a monoamine reuptake inhibitor BUT also indirectly causes the increase & releaseof Dopamine and to a lesser extent Norepinephrine

Cocaine a Tropaine alkaloid is a VERY potent & rapid acting Triple Reuptake Inhibition
DAT > SERT >> NET ….which is basically the most desirable balance of these monoamines

IPH (Isopropylphenidate) is identical to Methylphenidate in its DAT action but possess only 1/3 activity to the NET, which had a better safety profile , less increase in BP& HR ……but Ritalin (Methylphenidate) is already the safest dopaminergic stimulant…..MUCH safer then the Amphetamines concerning cardiovascular concerns

Ritalin (Methylphenidate) is also VERY Effective at enducing Euphoric, mood-boosting, antidepressant properties commonly prescribed along side Opioid narcotic analgesic medications to reduce sedation, improve impaired cognitive function and increase vigilance energy and enhance the painkilling properties of the opioid analgesic

I’ve been on Ritalin (Methylphenidate) for 20+ years …..had 5,000mg of Isopropylphenidate & 4F-MPH and non of these compounds even come close to the usefulness, safety profile, and effectiveness of this safe “mild dopaminergic stimulant” as CIBA Pharmacologicals states on their ads

 

[dimlocator]

MPH / EPH / IPH ….all 3 Phenidates have been extensively studied in medical journal studies

IPH Isopropylphenidate was/is a compound with promising attributes and was extensively studied for its application in treating ADHD, and other therapeutic usages in Canada

Ritalin (Methylphenidate) considered a “Classice Amphetamine” in numerous medical literature as is very unique MOA isn’t a straight forward DNRI (such as Bupropion/Wellbutrin). Ritalin (Methylphenidate) is nearly identical to Cocaine in its MOA, both being classified as “Inverse Agonists” and the 2 compounds both compete for the same binding sites inside the mammalian CNS DAT in regions responsible for pleasure & reward

Ritalin (Methylphenidate) is a monoamine reuptake inhibitor BUT also indirectly causes the increase & releaseof Dopamine and to a lesser extent Norepinephrine

Cocaine a Tropaine alkaloid is a VERY potent & rapid acting Triple Reuptake Inhibition
DAT > SERT >> NET ….which is basically the most desirable balance of these monoamines

IPH (Isopropylphenidate) is identical to Methylphenidate in its DAT action but possess only 1/3 activity to the NET, which had a better safety profile , less increase in BP& HR ……but Ritalin (Methylphenidate) is already the safest dopaminergic stimulant…..MUCH safer then the Amphetamines concerning cardiovascular concerns

Ritalin (Methylphenidate) is also VERY Effective at enducing Euphoric, mood-boosting, antidepressant properties commonly prescribed along side Opioid narcotic analgesic medications to reduce sedation, improve impaired cognitive function and increase vigilance energy and enhance the painkilling properties of the opioid analgesic

I’ve been on Ritalin (Methylphenidate) for 20+ years …..had 5,000mg of Isopropylphenidate & 4F-MPH and non of these compounds even come close to the usefulness, safety profile, and effectiveness of this safe “mild dopaminergic stimulant” as CIBA Pharmacologicals states on their ads

I honestly adore ritalin and especially with opioids…wow!! meth and opioids are great. coke and opioids too but theres more constant redosing with coke and the way it fucks your veins…main downside to meth for me is unintentionally staying awake for days and beginning to smell like meth after a while
For me ritalin is perfect. Both alone oral/snorted/IV’d and specifically IV’d with Hydromorphone/Morphine/Heroin. But like every time Ive read about the effects of methylphenidate with opioids Im reminded of how much I really enjoy it

Subtle and functional yet powerful and pleasurable enough so its not too in your face or overpowering - doesnt overtake the rush of the opioid in any way instead working perfectly alongside it
longer but not TOO long of a duration
little to no comedown or anxiety or negative side effects (aware this is pretty unique, many people dislike ritalin for uncomfortable/intense comedowns and anxiety/physical side effects)
boosts opioids in a different way than other stimulant/opioid combinations like they feel like they work together in terms of eachothers qualities (whereas in my experience meth and hydromorphone for example is a good combo but its like youre high on the two of them at once and you can tell / have one drug overpower the other, it doesnt come together the same way ritalin does with opioids)
bonus point is free for me!
bonus point 2 tastes a certain kind of satisfying when IVd (atleast XR bead formulations)

they just work so well together. Always balanced between both worlds without needing to be as precise with doses or ratios