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  • AADD Moderators: Tronica

Is this stack safe??

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NotAgain!!

Ex-Bluelighter
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Jul 27, 2011
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500mg of GABA, 500mg of l-tyrosine, 800mg of pericitam, 500mg of L-Tryptophan, 100mg of 5-htp, a multivitamin, a multimineral, a caltrate, omega 3, and sir johns wort twice a day... + at least an hour of exercise a day for natural endorphins... feels good man

I'm saying NO, it ain't safe. My mate's mate ordered all that shit in from overseas.
 
Doubt there would be much to worry about.

Not sure about the GABA. What does it do?
 
^ the gaba will be a waste of money. Phenibut works but GABA by itself doesn't cross the BB barrier.

There's a potential hazard mixing st john's wort (MAOI) and the 5-htp (serotonin precursor) too. tell him to take one or the other, not both.

Rest of the stack looks okay, especially the hour of exercise a day :)
 
GABA does have some effects, slight sedation and weird electric body/brain zaps. Well, the stuff my mate gave me does anyways.

Phenibut is good but withdrawal doesn't feelsgoodman
 
Whats the issue with St Johns Wort and 5-htp? Ive been taking some Wort in the morning with my nootropic regimen, while I usually take some 5-htp at night to help sleep.

Is it just taking them together that could be hazardous?
 
500mg of GABA - Waste of money.

500mg of l-tyrosine - Dopamine/dark skin causing agent.

800mg of pericitam - Piracetam is good.

500mg of L-Tryptophan - Warm milk? Isn't tryptophan also converted over to 5-HTP?

100mg of 5-HTP - Again, 5-HTP.
"When combined with MAOIs or SSRIs, 5-HTP can cause acute serotonin syndrome."

a multivitamin, a multimineral, a caltrate, omega 3, and

sir johns wort twice a day - could be an interaction with the 5-HTP

+ at least an hour of exercise a day for natural endorphins... feels good man


Interactions between your selected drugs
st. john's wort ↔ 5-hydroxytryptophan

Applies to: st. john's wort, 5-hydroxytryptophan

MONITOR CLOSELY: Concomitant use of agents with serotonergic activity such as serotonin reuptake inhibitors, monoamine oxidase inhibitors, tricyclic antidepressants, 5-HT1 receptor agonists, ergot alkaloids, lithium, St. John's wort, phenylpiperidine opioids, dextromethorphan, and tryptophan may potentiate the risk of serotonin syndrome, which is a rare but serious and potentially fatal condition thought to result from hyperstimulation of brainstem 5-HT1A and 2A receptors. Symptoms of the serotonin syndrome may include mental status changes such as irritability, altered consciousness, confusion, hallucinations, and coma; autonomic dysfunction such as tachycardia, hyperthermia, diaphoresis, shivering, blood pressure lability, and mydriasis; neuromuscular abnormalities such as hyperreflexia, myoclonus, tremor, rigidity, and ataxia; and gastrointestinal symptoms such as abdominal cramping, nausea, vomiting, and diarrhea.

MANAGEMENT: In general, the concomitant use of multiple serotonergic agents should be avoided if possible, or otherwise approached with caution if potential benefit is deemed to outweigh the risk. Patients should be closely monitored for symptoms of the serotonin syndrome during treatment. Particular caution is advised when increasing the dosages of these agents. The potential risk for serotonin syndrome should be considered even when administering serotonergic agents sequentially, as some agents may demonstrate a prolonged elimination half-life. For example, a 5-week washout period is recommended following use of fluoxetine before administering another serotonergic agent. If serotonin syndrome develops or is suspected during the course of therapy, all serotonergic agents should be discontinued immediately and supportive care rendered as necessary. Moderately ill patients may also benefit from the administration of a serotonin antagonist (e.g., cyproheptadine, chlorpromazine). Severe cases should be managed under consultation with a toxicologist and may require sedation, neuromuscular paralysis, intubation, and mechanical ventilation in addition to the other measures.
Other drugs that your selected drugs interact with

5-hydroxytryptophan interacts with more than 50 other drugs.
st. john's wort interacts with more than 300 other drugs.

Interactions between your selected drugs and food
st. john's wort ↔ food

Applies to: st. john's wort

GENERALLY AVOID: An isolated case report suggests that foods containing large amounts of tyramine may precipitate a hypertensive crisis in patients treated with St. John's wort. The mechanism of interaction is unknown, as St. John's wort is not thought to possess monoamine oxidase (MAO) inhibiting activity at concentrations achieved in vivo. The case patient was a 41-year-old man who had been taking St. John's wort for seven days prior to presentation at the emergency room with confusion and disorientation. The patient recalled last eating aged cheese and having a glass of red wine approximately 10 hours prior to admission. No other cause of delirium or hypertension could be identified.

MANAGEMENT: Until further information is available, patients treated with St. John's wort should consider avoiding consumption of protein foods in which aging or breakdown of protein is used to increase flavor. These foods include cheese (particularly strong, aged or processed cheeses), sour cream, wine (particularly red wine), champagne, beer, pickled herring, anchovies, caviar, shrimp paste, liver (particularly chicken liver), dry sausage, figs, raisins, bananas, avocados, chocolate, soy sauce, bean curd, yogurt, papaya products, meat tenderizers, fava beans, protein extracts, and dietary supplements. Caffeine may also precipitate hypertensive crisis so its intake should be minimized as well.



Whatever happened to HR?
 
^ yeh seriously why not put all of that in the first post? That's also the interaction I pointed out.... what ever happened to reading posts in the thread you started?
 
[snip]
^ yeh seriously why not put all of that in the first post? That's also the interaction I pointed out.... what ever happened to reading posts in the thread you started?

Nah, I found this awesome drug interaction checker website...I did read ya post belarki...No respect, I'm telling ya, from DM and JP.
 
Last edited by a moderator:
Alright I think this thread has run its course. Several abusive posts and those quoting them have been removed & the original question has been adequately addressed.
 
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