Is this something to do with my mary or what ?

[phactor]

Sounds strain related. Sounds like you had a strain that was a good blend, a bit heavier on the Indica side.

Sativa gives you a trippier, often more energetic high. The down side of this is that it can cause paranoia. Sativa's now have this effect with me. Indicas tend to cause more of a "downer" type high with less confusion. So nowadays I only smoke indica dominant buds. Its much easier for me to manage Indica highs.

 

[cloud_nine]

Uh...weed definitely works by releasing dopamine receptors...not serotonin

EDIT:http://www.nida.nih.gov/ResearchReports/Marijuana/Marijuana3.html

 

[Tikhil]

"In addition, it has been shown that cannabinoids, through an unknown mechanism, activate endogenous opioid pathways involving the μ1 opioid receptor, precipitating a dopamine release in the nucleus accumbens. The effects of the drug can be suppressed by the CB1 cannabinoid receptor antagonist rimonabant (SR141716A) as well as opioid receptor antagonists (opioid blockers) naloxone and naloxonazine.[12]"

From Wikipedia

 

[Roger&Me]

Weed acts on DOPAMINE ? !?!?!?

This is completley new .
Is this particular strains or ... ?
And can someone else confirm this?

Cannabis not only increases dopamine as a direct pharmacological effect, but also the fact that its a pleasurable activity will effect the dopaminergic mesolimbic pathway. Sex is another great example of indirect elevation of dopamine induced by pleasurable activity.

 

[marijuana-kid]

Cannabis not only increases dopamine as a direct pharmacological effect, but also the fact that its a pleasurable activity will effect the dopaminergic mesolimbic pathway. Sex is another great example of indirect elevation of dopamine induced by pleasurable activity.

it increases dopamine while high or in longterm ?


i find it hard to believe that it acts on dopamine in any ways whatsoever .
In the longterm it doesnt have any affect on motivation and if anything it kinda lowers it lol (which is controlled by dopamine)

and also while high it definitely lowers my motivation lol