Is this a very strong CANCER coursing cathinone ?

[raising_da_piggy]

breaking a resonance alien conundrum like bread now aryl is my conairy on the otherside of moon. Alkenes are now in the stratosphere, i think they found that on the moon as phenyl acetone.

 

[Smyth2]

If SIPI5357 & SIPI5056 are too complicated for you to synthesize I found another Chinese invention that similarly uses BzP as the amine, but only uses propiophenone as the source of the cathinone.

Here is the idea:

BzP-Phenyl-1-propanone
2-(4-Benzylpiperazin-1-yl)-1-phenylpropan-1-one
https://pubchem.ncbi.nlm.nih.gov/compound/69054294

Dual utility as analgesia, ataractic, and antidepressant with few sideeffects.

[1] Jianqi Li, et al. WO2003097623 (to Nhwa Pharmaceutical Corp).
[2] Jianqi Li, et al. WO2003101974 (to Shanghai Institute of Pharmaceutical Industry).

 

[3DQSAR]

If SIPI5357 & SIPI5056 are too complicated for you to synthesize I found another Chinese invention that similarly uses BzP as the amine, but only uses propiophenone as the source of the cathinone.

Here is the idea:

BzP-Phenyl-1-propanone
2-(4-Benzylpiperazin-1-yl)-1-phenylpropan-1-one
https://pubchem.ncbi.nlm.nih.gov/compound/69054294

Dual utility as analgesia, ataractic, and antidepressant with few sideeffects.

[1] Jianqi Li, et al. WO2003097623 (to Nhwa Pharmaceutical Corp).
[2] Jianqi Li, et al. WO2003101974 (to Shanghai Institute of Pharmaceutical Industry).

I'm guessing it's a prodrug. Isn't there an antidepressant that is metabolized into meta-chloro benzylpiperizine? This strikes me as possibly being similar.

 

[emkee_reinvented]

So you not realising you, he/ her and i all are talking to the sky.
Our your so called self, who observes the words that form
somehow in the brain. You inner TV.

And after giving em a interpretation,
decide s to or not to write em down.
Which is a art of its own,
seeing how interpretations of them same words,
have created many absurdist situations.

Different interpretations rule. Khaos at best
So @neversickanymore & @ShulginsReincarnation.
Who are you writing to, as that is what we technically do.

 

[Smyth2]

I'm guessing it's a prodrug. Isn't there an antidepressant that is metabolized into meta-chloro benzylpiperizine? This strikes me as possibly being similar.

I assume you are probably thinking of trazodone, Nefazodone, Etoperidone etc (i have a list of them but won't bother posting an exhaustive list).

As for BzP, this is the total list of derivatives:

• Befuraline
• CL-275838 (Cognitive enhancer)
• EGIS-7625
• LSP10-0500 (CID:1913642)
• SIPI5357
• Piberaline
• S-21007 [153628-86-5]
• SANT-1
• UA8967 [17511-50-1] (cancers)
• 1-(3,3-diphenylpropyl)-4-benzylpiperazine*
• RMI 60950
• NSI-189
• hAChE/Aβ1-42-IN-1

*Tadayuki Suzuki & Toshiharu Megumi, US3957790 (1976 to Tokyo Tanabe Co Ltd).

It's a fusion of Amfepramone & BzP. I'd expect it is already fully active and not just a pro-drug.

 

[raising_da_piggy]

Being a disubstitution all in all,what about a condensation solution of ppa as back bone ? Oxidized with butyl phenyl methylpropional ? As I realise the ketone will be attracted to a beta position on the tertry alkyl halide! ????????

 

[raising_da_piggy]

I'm thinking in the oxidation there will be a bond lost to hydrogen right ? And maybe nitric acid will form ? Then aqueous ammonia will give it the amine wich it wants I.e nh2! Am I right in thinking this will work because ammonia is basic ? Do I have to see it go threw an endothermic reaction in the glass vessel ? Then apply ammonia. ???? I have only just started thinking about this compound so maybe I'm missing the patently obvious?, I've totally scraped the idea of using napthalene,,, as it seems too toxic...

I'm presuming the h o on the benzene ring will get converted into a secondary alcohol?

 

[raising_da_piggy]

I believe the transfer to the beta is a conjugate reaction so to me this makes sense. Also homolytic / ligand transfer of elecktrons is in the mix so is there some thing to do with valencey and nitrogen ? Is this when the activation of nitric acid would be there ? En carnate ? Lol

I can't really say where i bought them or what both starting precursors are !

 

[raising_da_piggy]

But yeah if it helps I'm hoping my compound is all wraped up nice and triganol and acetyl . I also am using the right acid and alcohol on my back bone/substrate, oxidizing agents, moiety giving salts . Thanks for the read on bzp precursors/intermediates and the like, going to go through them properly now. Cheers g.

 

[raising_da_piggy]

As butyl ether is approximately 5.2 I'm assuming I'm going to have to aim for this and then as it's some sort of cathinone buffer it to 7.5 ? Then the fun with light and aluminum chloride.

 

[raising_da_piggy]

Just to say.... I realise psychoactive compounds are illegal, but these are sndri
Anti depressants and like the man says they are not psychoactive in the same way an actual stimulant would be ( in my case ).

 

[3DQSAR]

I assume you are probably thinking of trazodone, Nefazodone, Etoperidone etc (i have a list of them but won't bother posting an exhaustive list).

As for BzP, this is the total list of derivatives:

• Befuraline
• CL-275838 (Cognitive enhancer)
• EGIS-7625
• LSP10-0500 (CID:1913642)
• SIPI5357
• Piberaline
• S-21007 [153628-86-5]
• SANT-1
• UA8967 [17511-50-1] (cancers)
• 1-(3,3-diphenylpropyl)-4-benzylpiperazine*
• RMI 60950
• NSI-189
• hAChE/Aβ1-42-IN-1

*Tadayuki Suzuki & Toshiharu Megumi, US3957790 (1976 to Tokyo Tanabe Co Ltd).

It's a fusion of Amfepramone & BzP. I'd expect it is already fully active and not just a pro-drug.

I hadn't carried out an exhaustive search but it's interesting that the meta chloro benzylpiperizine moiety turns up in so many places.

Now I was offered but turned down the chance to sample the stuff as reports were mixed, shall we say.

 

[Smyth2]

I have read about the pharmacology and mCPP is stated to be a 5-HT2C agonist and has also been described as a panicogen.

5-HT2C receptors are linked to dopamine release and 5-HT2c agonists are believed to be useful for treating cocaine addiction:

Bubar MJ, Cunningham KA. Serotonin 5-HT2A and 5-HT2C receptors as potential targets for modulation of psychostimulant use and dependence. Curr Top Med Chem. 2006;6(18):1971-85. doi: 10.2174/156802606778522131. PMID: 17017968.

mCPP has been described as a piperazine that is useful in treating obesity also.

Bickerdike MJ. 5-HT2C receptor agonists as potential drugs for the treatment of obesity. Curr Top Med Chem. 2003;3(8):885-97. doi: 10.2174/1568026033452249. PMID: 12678838.

Strong 5-HT2C agonism is the reason why PAL-287 was being explored as an anorectant.

Now although mCPP is suggested to blunt the addictive effects of cocaine, I have read reports that 5-HT2C antagonism may be useful in treating depression.

Di Giovanni G, Di Matteo V, Pierucci M, Benigno A, Esposito E. Central serotonin2C receptor: from physiology to pathology. Curr Top Med Chem. 2006;6(18):1909-25. doi: 10.2174/156802606778522113. PMID: 17017966.

Esposito E. Serotonin-dopamine interaction as a focus of novel antidepressant drugs. Curr Drug Targets. 2006 Feb;7(2):177-85. doi: 10.2174/138945006775515455. PMID: 16475959.

 

[3DQSAR]

'Panicogen' - what an emotive term. I intend to use it as often as possible ;-)

 

[raising_da_piggy]

Being a disubstitution all in all,what about a condensation solution of ppa as back bone ? Oxidized with butyl phenyl methylpropional ? As I realise the ketone will be attracted to a beta position on the tertry alkyl halide! ????????

A wee "Lilial" mistake.... no halide at this point... but I'm sure the ketone will be attracted to tertiary alkyl...Also here are the ideas for when the tinkering goes on;
bk pbdb
N - propylnorbutylone
N - propyl norbutylone
Propyl butylone
Propyl butylone ( mono )
N-isoprpyl butylone
1-( 1,3-benzodioxy-5-yl)-2- (isoppropylamino ( butan-1- one
On the note of ketone... could two ketones, one at the head end and one at the tale end be problematic to the way receptors read the overall mono amine information And interact with the whole bundle ?

Also...I plan on using ethanol as a sort of decanter for the ammonia ... will this work ?

 

[raising_da_piggy]

I assume you are probably thinking of trazodone, Nefazodone, Etoperidone etc (i have a list of them but won't bother posting an exhaustive list).

As for BzP, this is the total list of derivatives:

• Befuraline
• CL-275838 (Cognitive enhancer)
• EGIS-7625
• LSP10-0500 (CID:1913642)
• SIPI5357
• Piberaline
• S-21007 [153628-86-5]
• SANT-1
• UA8967 [17511-50-1] (cancers)
• 1-(3,3-diphenylpropyl)-4-benzylpiperazine*
• RMI 60950
• NSI-189
• hAChE/Aβ1-42-IN-1

*Tadayuki Suzuki & Toshiharu Megumi, US3957790 (1976 to Tokyo Tanabe Co Ltd).

It's a fusion of Amfepramone & BzP. I'd expect it is already fully active and not just a pro-drug.

yep , how profound, I can imagine bzp is a great source for ammonia back bone.
I think it is sourced for this reason.

 

[4DQSAR]

FYI the first beta blocker to be marketed was pronenthanol. It was taken off the market when it was established that in man, one of the metabolic pathways was the formation of an epoxide bridge between the two benzene rings of the napthalene system. However, propranalol actually has the same active conformation but the design precludes the formation of said epoxide.

However much you test a medicine in animal models, it's hard to totally eliminate the possibility of differing metabolism between species resulting in a toxic metabolite. That is why even medicines that have recieved a GSL are still technically in 'stage IV trials' AKA 'pharmacovigilance' i.e. the makers continining to look at data in case statistics suggest a medicine produces an unexpected side-effect.

 

[raising_da_piggy]

Just a hunch.....there be 1% benzalkonium chloride in the ethanol, is this to stop clandestine chemistry? Would it totally screw things up when ammonia is mixed or make the halogen reaction not as possible?

 

[4DQSAR]

It serves a number of purposes. I believe it has a bitter taste and is toxic so I assume ethanol with 1% benzalkonium chloride added won't attract duty as it cannot be drunk. It also has antiseptic qualities but I susppec it's purpose is to deneture ethanol so it preclude consumption.

It's also a PTC and so may improve the cleaning properties of ethanol containing it.

But I really don't know when ethanol would be better than methanol if it's being used as a solvent. The simplest reductive amination I know of uses methanol, ammonium chloride (or methylamine hydrochloride), anhydrous sodium hydroxide and of course, sodium borohydride.

The trick is that the NaOH freebases the amine, absorbs the water produced by imine formation (so it's not a reversible reaction) and slightly increases the pH so the NaBH4 is stable. This take 2 hours and at RT.

 

[raising_da_piggy]

After carefully scrutinizing the situation at hand I realised ppa has an oh on the beta and also a nh2 on the tale ( seems I've been looking at a different compound)...if I can collect this as a solution and fused it to bmhca would I obtain a novel cathinone ?