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Is this a very strong CANCER coursing cathinone ?

raising_da_piggy

raising_da_piggy

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Do you think a cathinone with a naptha double ring and a chlorine bond has more carcinogenic potential than napthyrone? hence why this compound does not even exist ? Wary on this one or not ? Is This one for the future market ?.?
 
Oh yeah and it's not enantiomer secure. From the information now that is coming threw surrounding controversy is suggesting it's also racemic, so , from my understanding this also could add to cancer problems....
 
there's no interaction with isomer that will course carcinogenic effects... but enantiomers that or optical isomer of each other in this racemic compound I am not to aware of... any clues ? HAVE YOU SEEN WHAT IT IS YET ? 😆😆
 
Just because a molecule contains naphthalene doesn't not mean it will behave the same as naphthalene. Many molecules contain benzene, a suspected carcinogen but themselves are not carcinogenic.
 
That reminds me of a recent SNDRI compound reported called SIPI5357.

Weng, Zhijie; Zheng, Yongyong; Li, Jianqi (2015). "Synthesis, Antidepressant Activity, and Toxicity of the Erythro/Threo Racemates and Optical Isomers of 2-(4-benzylpiperazin-1-yl)-1-(5-chloro-6-methoxynaphthalen-2-yl)hexan-1-ol". Chemical Biology & Drug Design. 85 (4): 454–460. doi:10.1111/cbdd.12438.

See also: SIPI5056.

Weng Z, Li J. Synthesis and antidepressant activity of optical isomers of 2-(4-benzylpiperazin-1-yl)-1-(5-chloro-6-methoxynaphthalen-2-yl) propan-1-ol (SIPI5056). Bioorg Med Chem Lett. 2010 Feb 1;20(3):1256-9. doi: 10.1016/j.bmcl.2009.11.108. Epub 2009 Nov 27. PMID: 20022503.

I don't think we can say with certainty whether the compounds will be carcinogenic without further testing.
 
Smyth2 said:
That reminds me of a recent SNDRI compound reported called SIPI5357.

Weng, Zhijie; Zheng, Yongyong; Li, Jianqi (2015). "Synthesis, Antidepressant Activity, and Toxicity of the Erythro/Threo Racemates and Optical Isomers of 2-(4-benzylpiperazin-1-yl)-1-(5-chloro-6-methoxynaphthalen-2-yl)hexan-1-ol". Chemical Biology & Drug Design. 85 (4): 454–460. doi:10.1111/cbdd.12438.

See also: SIPI5056.

Weng Z, Li J. Synthesis and antidepressant activity of optical isomers of 2-(4-benzylpiperazin-1-yl)-1-(5-chloro-6-methoxynaphthalen-2-yl) propan-1-ol (SIPI5056). Bioorg Med Chem Lett. 2010 Feb 1;20(3):1256-9. doi: 10.1016/j.bmcl.2009.11.108. Epub 2009 Nov 27. PMID: 20022503.

I don't think we can say with certainty whether the compounds will be carcinogenic without further testing.
Click to expand...
Thank you. Interesting stuff...
TheFunkeeJunkee said:
Just because a molecule contains naphthalene doesn't not mean it will behave the same as naphthalene. Many molecules contain benzene, a suspected carcinogen but themselves are not carcinogenic.
Click to expand...
absolutely just some sort of tweak and your out of carcinogen territory. Some such base stuffs and pow! Cancer. Look at thalidomide for example...

The problem with napthalene is it is dna'y
Due to double helix...I can't quite fathom this being sinister but apparently it's gonna cleave open cell walls...
 
Sorry my weary fingers have dwindled ,., Thalidomide is racemic and as any good chemist will no this does not mean it has to be basic, Neutral , acidic. Interestingly In fact from reading an old organic chemistry book it details accounts of racemic tartaric acid being studied as one of the first observed racemic compounds about 100 years ago..also in the same book or pile of five i bought last summer there are acounts of naptha being first discovered in a small village in italy , workers dug big holes in the ground and the oil is collected after it liberates/percipitates. Strangely there is no mention online of this tale, but I have accounts .. it's there in broad day light ( so to speak ). Also napthalene is used to make 'indigo' by being converted by oxidation to phthalic acid from wich "phthalimide" is obtained( un fucking canny) ! The pthalimide by action of caustic soda and chlorine is converted to anthranilic acid, this is condensed with monochloracetic acid to form phenyl-glycine-o-carboxylic acid, wich has a fusion, with caustic potash and forms indoxyl. Indoxyl on oxidation yields indigo !
Yes my baby blue eyes , indigo !
 
I'm not trying to make some thing like thalidomide into a joke, it's no joke, a very sad affliction on humanity ...I've worked with physically challenged folk. The challenges they encounter are gargantuan. They have nothing but my admiration.

So judging by this information ; is chloral bmapn going to be a drug of a cancerous toxic broth or are we on to a stroke of good luck ?
 
It is very similar in molecular structure to SIPI5056 & SIPI5357, which are both Chinese medicines developed as SNDRIs.

I don't really know very much about cancer though so I can't answer your question. Why do you ask though?

If it has already been made then it would be tempting to try some but i can't answer your question over whether it is going to be carcinogenic or not.
 
To be quite honest , I would not want to try chloral bmapn, it all seems so f***ing sketch , I can imagine by products of this are gonna polute the land even if the final compound is not considered carcinogenic like thefunkeejunkee states. How ever , what about a chloral butylone ? Cheff says he can swap napthalene for a butyl pre cursor ... halogen reaction goes fourth to pluck the product as of salt in the same way ( elecktrophilic substitution )...reduction / sn1 reaction before hand.... hit me ! 😑😍😐😙😙😅😘😘😅😘😶😎I was not a jock . The dj, and the news @pact... not about to tell you the pre cursors ... cooking drugs is dangerous.??????????
 
Approximately 60% Of Psychotropic Prescription Drugs Have Been Found To Be Carcinogenic. As An Aside, Amphetamine Is Not One Of Them.
 
Chloral

That reminds me of a recent SNDRI compound reported called SIPI5357.

Weng, Zhijie; Zheng, Yongyong; Li, Jianqi (2015). "Synthesis, Antidepressant Activity, and Toxicity of the Erythro/Threo Racemates and Optical Isomers of 2-(4-benzylpiperazin-1-yl)-1-(5-chloro-6-methoxynaphthalen-2-yl)hexan-1-ol". Chemical Biology & Drug Design. 85 (4): 454–460. doi:10.1111/cbdd.12438.

See also: SIPI5056.

Weng Z, Li J. Synthesis and antidepressant activity of optical isomers of 2-(4-benzylpiperazin-1-yl)-1-(5-chloro-6-methoxynaphthalen-2-yl) propan-1-ol (SIPI5056). Bioorg Med Chem Lett. 2010 Feb 1;20(3):1256-9. doi: 10.1016/j.bmcl.2009.11.108. Epub 2009 Nov 27. PMID: 20022503.

I don't think we can say with certainty whether the compounds will be carcinogenic without further testing.

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raising_da_piggy​

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How cool to add a via substitution piperazine , I once tryed to obtain piperazine with acetone extraction of rainbow pepper , managed to get a very bright conairy yellow..wanted it for an efficient elecktron transfer intermediate .to make some sort of amphetamine..sadly tjis was trying to run before you can walk...oh well..
 
Here, i found patents for both SIPI5357 & SIPI5056.

Abstract
The invention discloses 1-butyl-2-hydroxyl aralkyl piperazine derivatives and their use as antidepressants. The derivatives of the present invention have triple inhibition effect on the reuptake of 5-HT, NA and DA, and can be administrated to the patients in need thereof in form of composition by route of oral administration, injection and the like. Compared with clinically currently used dual targets antidepressants (such as venlafaxine), said derivatives may have stronger antidepression effect, broader indications, faster onset and lower neurotoxicity and side reaction; and said derivatives have stronger antidepression activity, lower toxicity, higher bioavailability, longer half life and better druggablity, compared with aryl alkanol piperazine derivatives and optical isomers thereofdisclosed in prior art.

[1] Jianqi Li, et al. WO2003101974 (to Shanghai Institute of Pharmaceutical Industry).
[2] Jianqi Li, et al. WO2010040315 (to Shanghai Institute of Pharmaceutical Industry, CSPC Zhongqi Pharmaceutical Technology Shijiazhuang Co Ltd).
 
ShulginsReincarnation said:
I've noticed a lot of members here do this; I took an educated guess that it was drug related the last time round and I was correct. Could be a similar scenario here lol
Click to expand...
"Maybe, I am just talking to myself" aint you. Sounds problematic, it aint.



Hurting won t help, drugs sharpen the mind, in most cases !

Edit: don t make shame of the name you choose,
as he was on drugs. Some of his life time.
And talking to the world. Just that you know.
 
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