• Neuroscience & Pharmacology Discussion Welcome Guest
    Posting Rules Bluelight Rules
    Recent Journal Articles Chemistry Mega-Thread
    FREE Chemistry Databases! Self-Education Guide

  • N&PD Moderators: Skorpio

Is there way to test for Tylenol left after a CWE?

S

smp150

Bluelighter
Joined
Apr 16, 2008
Messages
75
Mods, if this is in the wrong forum feel free to move it.

Anyway, I have always wondered about the possibility of a way to know just how much Tylenol is left in your mixture after a CWE. Is there a way to test for that without needing a chem lab?
 
smp150 said:
Mods, if this is in the wrong forum feel free to move it.

Anyway, I have always wondered about the possibility of a way to know just how much Tylenol is left in your mixture after a CWE. Is there a way to test for that without needing a chem lab?
Click to expand...

sort of, If I remember right paracetamol-tylenol makes a purple colour when ferric chloride solution is dropped into a solution of it in water. ferric chloride is circuit board etcher.
this is a very sensitive test and the stronger the purple colour the more paracetamol-acetaminophen present.
 
knowing that there's going to be some APAP left no matter what, I think the only reasonable test would have to change very slowly, or you'd too easily reach max coloration.
 
Ham-milton said:
knowing that there's going to be some APAP left no matter what, I think the only reasonable test would have to change very slowly, or you'd too easily reach max coloration.
Click to expand...


it is not as complicated as you suggest. in fact I can see a way of getting semiquantitative results,

dilution is the key.
A sample of the original BEFORE CWE material is dissolved say 10mg per ml in water to make the BEFORE CWE master reference.
the same amount of the material left AFTER CWE is dissolved in water at the same weight per ml as the BEFORE CWE master reference.[/B]
The BEFORE CWE master is then diluted to 2 3,4, 6, 8 10 and 16, (the number of dilutions would probably need to be modified by experiment. I cannot remember how sensitive ferric chloride is)

then 1 drop of 1% ferric chloride is added to the AFTER CWE,
1 Drop of Ferric chloride is added to the BEFORE CWE master reference,
1 drop of ferric chlorde is added to each of the diluted BEFORE CWE solutions.

The intensity of colour of the AFTER CWE solution will lie between two of the Before CWE diluted solutions, easy to do with a piece of paper. from this everything else is easy...

for example,
if the intensity of the colour of the AFTER CWE sample is darker than the 4x dilution but lighter than the 4x dilution then it is pretty certain that the AFTER CWE material contains 3-4 times less Acetaminophen per gram than the BEFORE CWE material. and as the manufacturers tell you how much acetaminphen is in the starting material you know approximately how much is in the AFTER CWE material.

I personally would use a spectrophotometer as it would save pissing about diluting solutions but that is just me.

Vecktor
 
ferric ions also complex with salicylates so that method can also be used on aspirin/salicylic acid pills

if the hydroxyl group on tylenol is acidic enough, and the calcium salt is insoluble, you could ppt out the salt and weigh it dry
 
Doesn't codeine also form an insoluble ppt. with calcium? If I remember correctly this is the way it is separated from morphine in in the manufacturing of heroin.
 
hm.. that's balls if it does ppt out. perhaps just solvent extraction then. no idea on solubilities. maybe DCM.
 
You must log in or register to reply here.
Top