Is methoxetamine a dopamine reuptake inhibitor?

[deckmunki]

Pretty much as the title. I've found that a *very* small dose (5-10mg) sublingually, roughly every 2-3 hours, gives me an incredible ability to focus on work, and (possibly due to the dissociative effects) almost completely inhibits my social anxiety which has been pretty much crippling my work and ability to socialise for the last, oh I dunno, 29 years... (!)

An additional factor which might support this (very basic, amateur question, I admit) is that mixing 30mg-ish methoxetamine with 30mg-ish methiopropamine, which it seems has dopaminergic effects, caused an acute and pronounced panic attack, hypertension, tachycardia, etc. Very unpleasant.

All hypotheses are welcome here as to why this might be - this drug seems to be doing some amazing things for me*

* It might equally be eroding my brain. What do I know?

 

[sekio]

Ketamine and PCP are, I don't see why MXE wouldn't be.

 

[hamhurricane]

And don't forget PCE...PCE is weaker than PCP as a DARI but it was noted by an author of a paper on the subject "PCE was much more effective in vivo than would have been expected based on its ability to inhibit reuptake in vitro." So yes, it is possible and judging by the subjective effects it certainly feels that way.

 

[amanitadine]

Yes all signs point to such. i thought Hugo had some receptor affinities for some of the 3-Meo subbed? (PCP/PCE?) Maybe that is wishful thinking...

But yeah, personally I found PCE to be quite a bit more manic and stimulating than PCP . I tend to associate these effects with DRI activity. And PCE was quite a bit more potent by weight. But....that doesnt extend to the 3-MeOs, as 3-MeO PCP is significantly more potent than 3-MeO PCE. All we can do is extrapolate (and guess) here....

 

[deckmunki]

Well, okay, everything so far looks promising. I suspect it will turn out to be a DRI going on its effects in vivo. If so... I wonder what the abuse or (more importantly?) any conceivable therapeutic potential might be...?

Could it be the perfect nootropic? (I.e. small doses act as a DRI with only a tiny bit of initial side effects, but if you try to abuse it, it puts you on the floor in a dribbling wreck and makes you look so silly, you don't do it again...? ;o)

 

[oSpherical]

I'm curious about this too, I find that MXE has the potential to give me pristine clarity and focus, and it has actually been helping me learn some stuff, since I can practice for hours on it and it feels like my memory retains everything.
It also leaves me with more optimism and motivation than anything I have ever tried before, it feels like a miracle in many ways. I've tried all manner of anti-depressants in the past, as well as nootropics, yet none can rival the clarity and pure motivation the afterglow of MXE leaves me with.

 

[RigaCrypto]

How long does this afterglow last for you, oSpherical? Do you get any kind of come-down from MXE?

 

[oSpherical]

I've been using it too often for there to be a long enough gap to give a real approximate length of time of the afterglow, but I can say that 2 days after dosing I tend to start feeling like my old self - despite that, MXE still has given me a long introspective tour which has put me off bad habits and such of mine, which I believe should persist beyond the afterglow.
I feel as though with therapeutic use it could help change my life for the better, but I can't resist the urge to use it recreationally.

And yes, I do get a slight comedown, but not an entirely unpleasant one. It's mostly due to dehydration, and sore muscles due to moving around too much, other than that, the transition from "tripping" to sober is extremely smooth, if anything I find the comedown to be the most productive part of the chemical, since this is when I can actually start doing tasks efficiently, while still having the euphoria and motivation without the disassociation.

I also find my social anxiety to be completely gone for a few hours after the come down, as does my need for sleep...

On another note, I find that tiny bumpts throughout the day do a great job at removing my appetite, it's making me wonder if it could be used to help with a diet...

 

[ConnectFor]

I'm curious about this too, I find that MXE has the potential to give me pristine clarity and focus, and it has actually been helping me learn some stuff, since I can practice for hours on it and it feels like my memory retains everything.
It also leaves me with more optimism and motivation than anything I have ever tried before, it feels like a miracle in many ways. I've tried all manner of anti-depressants in the past, as well as nootropics, yet none can rival the clarity and pure motivation the afterglow of MXE leaves me with.

I've felt this too.. complex concepts which I previously understood with some effort now seem straightforward and clear. I do fear its an illusion caused by the MXE though.

An adolescence in which I smoked a lot of cannabis led to social anxiety and depression in my twenties. I'm now mid thirties and having been prescribed SSRIs a couple of times to deal with very low mood I find they just seem to dull my senses so I just take 5-HTP and avoid stress which seems to keep me on a level.

MXE seems to be very effective in restoring or even boosting motivation, psychological balance, improving concentration, comprehension and empathy, and also improving my mood. Still, I fear its an illusion somehow, and want to understand whether it is something beneficial, or just something that has seduced me into believing it has these properties.

 

[Naggers]

almost completely inhibits my social anxiety

I find it does quite the opposite for me. I had a small (~15mg) dose one night last week before going out with friends, and ended up having a panic attack in a restaurant because 'everyone was looking at me'. I ended up spending most of the meal with my head down and one hand covering my face.