Weird that you didn't tolerate codeine phosphate but do the solpadeine. Do you know what codeine salt it contains? You might want to do a CWE to get the codeine separated from paracetamol.
Lyrica shouldn't give you anxiety but it's imo also nothing to take daily because it's effects subside very fast. Some people get long lasting effects against pain or anxiety though. While it has an indirect GABA promoting effect it doesn't attach to the GABA receptor complex itself. I guess you can only try for yourself and see what it gives you and what not. From a short term experiment you won't be in danger of withdrawal and not everybody gets it anyways, I for example was on 900mg and had next to no withdrawal.
Kind of makes sense to me. Pure codeine at a higher dose would be different than lower dose codeine combined with paracetamol (which enhances opioid effects creating a stronger feeling from a lower dose).
This could change things ( potentially especially if the user is mildly allergic to codeine (pseudo-allergy, not anaphylactic) or just doesn’t respond well to it in general for one of various common reasons.
But at a lower dose, with mainly the positive effects potentiated by the paracetamol along with the addition of caffeine, which would both speed up the metabolism for a more intense and magnified initial feeling (more concentrated release of morphine into the bloodstream),
along with the stimulant’s (caffeine) psychoactive effects.
This added stimulant would counter the depressive effects of the codeine (now metabolized into morphine), leaving a much more pleasant, uplifting and overall palatable euphoric experience, relative to a much more slowly metabolized codeine by itself.
These three drugs can work together very well, akin to taking other stimulants and opioids together.
Similar reason why people drink alcohol which cocaine.
Another classic similar example would be a combination of GHB and Meth.
Sub-Note: Despite popular opinion, GHB and meth/cocaine ect is actually quite a healthy combination.
I’m not in any way saying that meth is healthy in high doses, but pure GHB absolutely can be beneficial in many ways and as long as you’re not over dosing the stuff, the main risk is generally the excess sodium from taking too many consecutive doses (if you can source potassium based GHB powder and balance the two out every other dose this will offset this risk significantly (especially if keeping your magnesium/calcium ratios and water intake in order at the same time).
GHB eventually metabolizes in the body into just carbon dioxide and water. Nothing else.
(not talking about GBL or 14b here, they are absolutely very bad for you).
But back to the point, when combined with a stimulant like meth, it can induce several benefits to your body like lowering heart rate and blood pressure by dilating your cardiovascular system, and relaxing your muscles. And also relaxing your mind by inhibiting the fight or flight response brought on by the intense stimulant, putting significantly less stress on your body overall both physically and mentally.
Cocaine and alcohol have been shown to be quite unhealthy due to other interactions in the body, so the above examples of specific benefits when some uppers and downers are mixed are not universal and not a hard rule by any means.
Quite an interesting and useful bit of knowledge to pack away for a rainy day though, in my opinion.
others do not feel this. I find this phenom a bit curious but also know its typical of substance effects being varied.
