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  • BDD Moderators: Keif’ Richards

Is it safe to use isopropyl alcohol as a solvent for IM injection? (Etizolam)

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az5000

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Hi, I recently came along some Etizolam powder and 500ml of isoprolyl alcohol. As etizolam dissolves 1:1 in Isopropyl alcohol, it is the ideal solvent. I would be injecting 1 or 2ml intramuscularly, and was wondering if this was as safe as using distilled / bacteroscopic water. If not I don't mind sticking to the oral route, I just find that having a fast acting ROA (IM) is useful to have and benzos usually have a pretty nice rush associated with them when injected. THe isopropyl alcohol I have is from a chemist and has "Isopropyl alcohol EP" and is manufactured by JM Loveridge.

I'm (assuming) that it is pharmaceutical grade as it was bought at a chemist, and doesn't have a purity / percentage written on it. The etizolam was bought from a reuputable vendor and is quoted as being 99.5% purity and is a hard to handle white fluffy powder.
 
Don't think that's a good idea. Not sure on the specifics, but I don't think it's fully miscible with water, plus you're probably gonna get a lot of problems with it being metabolised.

The most commonly used solvent for IVing non water soluble drugs is propylene glycol, may be worth investing in that if you're planning on injecting benzos.
 
Isopropyl alcohol is miscible with water, but solubility/miscibility rapidly decreases in saline solutions (like the blood). Isopropyl alcohol and its main metabolite acetone are both toxic and CNS depressant. I believe the generally accepted LD50 to be in the 10-20 mL range for a normal sized adult (~200 mg/kg). Therefore, injecting 2 mL seems like an awfully stupid idea.
 
Alright, thanks for the fast replies. Would isopropyl alcohol be ok for oral dosing? I'd assume in such small amounts (1mg/1ml) wouldn't be dangerous.
 
I wouldn't use isopropyl if you can avoid it. Most OTC isopropyl alcohol has a bittering agent mixed in so oral use (even in small doses) is going to be anything but pleasant.
 
Why would they add a bittering agent to isopropyl alcohol?
It's an FDA-approved food additive...
Besides, the isopropyl alcohol in the OP was EP-grade.

I would also advice against oral dosing with isopropyl alcohol.
The LD50 is in the order of 10 mL for fuck's sake, you are talking about taking 1 or 2 mL...
Not exactly a safety margin.
 
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Say if I wanted to dissolve the etizolam in the isopropyl alcohol, and then put 1ml of the solution on blotter paper would that work alright? I'm not too bothered about the taste. (As in, wait for the isopropyl alcohol to dissolve and then the blotter paper will then contain 1mg of etizolam)
 
That would probably work, but you would need an awful lot of paper to apply 1 mL of solution.
So imo you'd be better off trying a sugar cube, try first with pure isopropyl alcohol and if that leaves the cube intact, try the spiked solution.
Perhaps you could also try a transdermal benzo-rub, haha, not sure if that would work but it would be marvellous used for a relaxing massage. =D
 
Originaly IM injections are for vitamins and immunizations shots , substances that are very irritating when injected , it can burn quite a bit. is this to get high , are you trying to get high. if thats the case IV is the way to go, im a medical student and i have administers injections and i dont recommend im injection.

you have to know what you are doing thus you can hit a nerve and really hurt yourself. please becareful
btw what are you trying to accomplish by administering it via IM im kinda lost in the mixture your trying to use , and what im trying to tell you is if you administer your solution in the wrong spot you can really hurt yourself.
 
Alright, thanks for the advice guys. I guesss IM using isopropyl alcohol is out of the question, so it's a case of dissolving it on a sugar cube and waiting for the iso to evaporate. Not really a problem considering oral bio-availability of etizolam is quoted as being 80%. It was mostly just a theoretical question.

Monkey - I was under the impression the preferred ROA for benzos (except oral and sublingual) was intramuscular. Was I wrong? It's not necessarily to get high, it's just useful to have a fast acting benzo on hand should a trip get out of hand etc.

3rd_I_blind - I know the "benzo rub" thing was just a joke, but it's actually pretty interesting :p. Assuming the Isopropyl alcohol didn't evaporate first, would the etizolam actually be absorbed transdermally?
 
az5000 said:
Alright, thanks for the advice guys. I guesss IM using isopropyl alcohol is out of the question, so it's a case of dissolving it on a sugar cube and waiting for the iso to evaporate. Not really a problem considering oral bio-availability of etizolam is quoted as being 80%. It was mostly just a theoretical question.

Monkey - I was under the impression the preferred ROA for benzos (except oral and sublingual) was intramuscular. Was I wrong? It's not necessarily to get high, it's just useful to have a fast acting benzo on hand should a trip get out of hand etc.

3rd_I_blind - I know the "benzo rub" thing was just a joke, but it's actually pretty interesting :p. Assuming the Isopropyl alcohol didn't evaporate first, would the etizolam actually be absorbed transdermally?
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in that case i would use SubQ in the fatty area of the body it is less irritating, IM hurts alot more then Subq also, in school we practice drawing blood and injections on each other lol so i know how each feels. it is also actually more practical thus subcutaneous injections are used to administer insulin shots. you have more spots to inject . IM is usualy done on the deltoid and the gluteous MEDIUS its the spot were so you can avoid the major nerves and blood vessels. just because full as to WERE you inject yourself. oh and remember to aspirate make sure you didnt hit a vessel and then disperse ALWAYS if you see blood after aspiration do not inject! also rub the spot after an injection
 
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With IM injections, muscles have a rich blood supply, so the substance you inject is absorbed into the bloodstream fairly quickly. With subcut injections, the substance you inject sits around for a lot longer as the blood supply is a lot poorer. This isn't a problem with injecting sterile, medical-grade substances, but injecting anything that may have become contaminated subcutaneously is running the risk of developing an abscess.

Benzodiazepines are administered IM in hospitals as they are usually given in a state of emergency (epileptic seizure or violent/aggressive psych patient) and IM is faster acting than subcutaneous, again due to the good blood supply..

The subcutanous route is usually only used for insulin and for when repeated injections are needed and IM is too painful (eg in palliative care)

Monkey is right, you do have to be careful giving yourself an IM injection in certain areas as you might hit a nerve (the buttocks for example) but outer thigh/deltoid is usually okay.

Overall though I wouldn't recommend IMing or subcut-injecting isopropyl alcohol!

Dissolving in propylene glycol and using liquid oral dosing sounds like the best plan to me :)
 
^ agree i mentioned subq thus its less risky in hitting a never and you are actually able to administer it more easily yourself . and the trick like i said is rubbing after injecting so the medication can be dispersed quicker if you don't rub it will sit around regardless via im or subq you actually rub the IM longer then you do a subq. but best way to go is oral dont mess with needles if you are not properly trained in doing so there is alot more behind it then just injecting.
 
^ wise words :) if anyone is contemplating injecting, even IM/subcut they should make sure they do their research properly and ideally have someone who knows what they are doing to teach them.. there is a lot more to it than just sticking a needle in yourself somewhere.
 
az5000 said:
3rd_I_blind - I know the "benzo rub" thing was just a joke, but it's actually pretty interesting :p. Assuming the Isopropyl alcohol didn't evaporate first, would the etizolam actually be absorbed transdermally?
Click to expand...
I expect fairly good uptake of benzodiazepines transdermally. However, you would probably want to use DMSO as muvolution already mentioned; it has the capacity to greatly enhance transdermal uptake (with the added benefit of causing a garlic-like taste in your mouth, yummy!).

i would use SubQ in the fatty area of the body
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With a Log P of above 3, I would not advise to inject etizolam in bodyfat.
Besides, I think the dangers of subcutaneous versus intramusuclar administration are comparable.
 
Alright, thanks for all the sound advice guys. I'm going to invest in some propylene glycol, dissolve in 1:1 ratio and stick to oral dosing. The transfermal dosing thing does sound pretty interesting though and I might experiment in future, make myself some extended release patches :p
 
The ears are an under-appreciated organ. I'm sure somebody somewhere has tried squirting something up their ear following the logic that it it close to their brain :p
 
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