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  • BDD Moderators: Keif’ Richards

Is it possible to safely combine amphetamines with mdma?

It's less neurotoxic than amphetamine I believe. It's not legal in the UK but its relatively easy to get ahold of.

Diazepam prevents excess dopamine from being produced/stops calcium channel influx to a large degree - and eases oxidative stress. it will take away from your roll slightly. I found the .5 of Xanax synergized very well with my high though.
 
Safest way would be the lowest dose of both, there comes a point where the amphetamine starts to really synergise with the MDMA, before that just speeds it up, after that overpowers the MDMA.

I have always taken my meth before the MDMA when combing... I usually take my MDMA, quarter a pill at a time around 2 hours after consumption... So really I have never combined the two to cause a peak together and I have always consumed my MDMA very slowly. TYpically this is what a combined meth+mdma night looks like

10pm: Consume meth, smoked.
12pm: Have a quarter of known and tested MDMA tablet.
12:30pm Have another quarter.

By now I am already feeling the MDMA and I just keep having quarters slowly, I usually have 1-2 pills max when I have meth combined... basically I slowly feel the MDMA come on and dont get any come up feelings or peaking I am just at a certain high that is fucking insane I am insaely euprhoic but charging at the same time, I have got the real munted feeling however but far from sleepy if that makes sense.

Deffintly reccomended consuming Vit C throughout the experience to help scavvenge the shit ton of free radicals flowing through your brain which is what I do. There is no real safe way but you can take those measures, stay hydrated aswell I notice I heat up very hard on meth and mdma combined which again contributes to the increased neurotoxicity of both combined.

Dont do it too often either!
 
I read somewhere that vitamin C can act as an oxidant as well as an antioxidant so using it to prevent neurotoxicity isn't the best idea? I don't know the science just read it somewhere amongst the plethora of threads. What's a better anti oxidant to use.

What kind of diazepam dose would you suggest? Would a dose of 2.5mg suffice, or does it need to be higher?

As for 4-FMA when you say easy to get hold of do you mean on the internet via vendors that will still ship to the UK? What about 4-FA instead of 4-FMA?
 
I have also read vitamin C can turn pro-oxidant - as can many other antioxidants. In one study, I dont have it on me I really must start book marking them, they gave rats high doses of MDMA that were shown to be neruotoxic - one group recieved the MDMA, another group recieved the same MDMA dose along with IV Vitamin C at high doses equivalent to off the top of my head a person consuming 15grams of Vit C and no neurotoxicity was observed, if such a high dose of Vit C were to turn pro oxidant in the presence of MDMA induced free radicals there would probably have been worse neurotoxicity? Again, thats in rats.

There are various antioxidants you can use, me personally I have always used vitamin c with MDMA or meth consumption, sometimes I have used Vitamin E aswell.

We need more human studies done on MDMAs neurotoxicity damn
 
Diazepam or any benzodiazepine for that matter completely kills the high of MDMA. The same but to a lesser degree can be said for methylphenidate.

Vitamin C has some efficacy in preventing oxidative stress, but certainly not to the degree which stimulants cause it.
 
Vitamin C completely kills an MDMA roll/amphetamine high. Look it up. The acidity destroys the amphetamine high, and the vitamin in itself stops the roll. Much much more so than diazepam. I strongly advise that you don't take vitamin c with the combo or with either individually. Many people drink orange juice at the end of their high for this reason.

Diazepam on the other hand synergises very well with the drugs, and at low doses (5mg) will not kill the high at all. Whoever says it will has clearly not experienced taking it in combination with them, or has taken it at high doses at the come down - thus leading them to believe it kills the high, which it does to some extent, but only at high doses and when the drugs are starting to wear off.
 
Hmm I've also heard the ketamine can prevent glutamine neurotoxicity, but to me that's just words, no clue what they mean other than "Do as much k as you want :D".
 
Haha yes it can and its regularly practiced. I think it's called candy flipping and a lot people enjoy the mix of the two drugs together.
 
I'm fairly sure candy flipping is acid and mdma, but k and mandy are stupidly euphoric when combined. Want to try GHB and mandy, ghb can sometimes be too euphric when used by itself, I can't wait to see what the combination is like :D
 
Not sure you could be right. Never really used hallucinogens or ketamine personally!

Yeah GHB is meant to be nice, but again I think that it's a comedown drug rather than a mixer with MDMA.. Again could be wrong, perhaps in a low dose, like Valium, it would be very nice.
 
synthetix said:
Not sure you could be right. Never really used hallucinogens or ketamine personally!

Yeah GHB is meant to be nice, but again I think that it's a comedown drug rather than a mixer with MDMA.. Again could be wrong, perhaps in a low dose, like Valium, it would be very nice.
Click to expand...

On another thread I started someone recommended taking it just after you've come up to make it feel like you have a 4 hour peak. I can imagine on a comedown it's quite nice as well.
 
Vitamin C killing the roll? I beg to differ. How so?

I know it can help excrete amphetamines from the blood stream slightly faster, but not my much. I would take 500mg tablets every hour when rolling and my rolls were still magnificent each weekend...
 
Do not mix MDMA and meth intentionally. It is super euphoric but NOT worth it. It is an extremely neurotoxic combo,probably the most brain damaging combo i can think of besides the dreadful piperazines. I've waken up feeling like i'm in hell from this combo more than once (tweaky pills). Also this combo makes your heart feel like it is beating out of your chest, not fun.
 
First time on meth i ended up doing a pill which i doubt was mdma but still my body lost the ability to regulate temperature and i was over heating bad whilst having many panic attacks. On their own its fine but for me, its not worth the risk of ruining my night again.
 
Yeah again, it is pretty dam neurotoxic there is no safe way.

You really dont realise how hot you are until you sit down on the toilet and literally feel a fuckload of heat comming off of you...
 
synthetix said:
Vitamin C completely kills an MDMA roll/amphetamine high. Look it up. The acidity destroys the amphetamine high, and the vitamin in itself stops the roll. Much much more so than diazepam. I strongly advise that you don't take vitamin c with the combo or with either individually. Many people drink orange juice at the end of their high for this reason.

Diazepam on the other hand synergises very well with the drugs, and at low doses (5mg) will not kill the high at all. Whoever says it will has clearly not experienced taking it in combination with them, or has taken it at high doses at the come down - thus leading them to believe it kills the high, which it does to some extent, but only at high doses and when the drugs are starting to wear off.
Click to expand...

5 mg diazepam for me will blunt the high before the roll, at the peak, and after, and every anecdote I've read on this and other forums says the same thing. Even when I took my diazepam the night before I would feel it taking away from the high. Maybe you react differently but I fail to see why when diazepam taken after or during the high will kill it and not before.

One thing that has shown to prevent the possible neurotoxicity of MDMA in rats is THC.

As for vitamin c during MDMA I've never heard of it blunting the high but I guess you live and you learn.
 
^
When it says amphetamines why does everyone suddenly leap to the conclusion I'm doing meth!?

Now THC definatelly does kill the high, but I'll give valium a whirl, but only at 2.5mg cause at 5 I just flat out want to sleep.

Okay apperently the reason why vitamin c can increase neurotoxicity is because of redox cycling where it's first reduced and then oxidises. Does anyone know any antioxidants other than melatonin that don't do this?
 
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