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  • N&PD Moderators: Skorpio

Is it possible to reverse caffeine tolerance with antipsychotics?

No and it is not recommended due to the risk of neurotoxicity and tardive dyskinesia.
 
Technically you could try to use an adenosine agonist for this, as caffeine is an antagonist ... this would make you at least very drowsy of course for the time while it is active. I'm curious though why adenosine agonists or reuptake inhibitors are so relatively unknown - some specific benzodiazepines and barbiturates are AdRIs, and the benzo antagonist flumazenil is one too (which could be the reason that it can be used clinically, if it was like naloxone for opioids [okay, this one is an inverse agonist, so not the best example, but slow infusion of flumazenil is a standard procedure for benzo w/d in some countries and appears to be superior to cold turkey], it would instantly induce severe, maybe life treatening seizures- or?) ... so adenosinergics could be very useful for drug withdrawal..
 
Yeah kinda feel like it's a way disproportionate measure, but granted caffeine tolerance / dependency can be pretty damn bad, cause mental and physical health issues... and some anti-psychotics like seroquel are regularly prescribed off-label for relatively minor things like sleep issues or taking some edge off. Taking heavy duty neuroleptics is another thing altogether of course.
And I'd still try the more typical strategies for caffeine dependency, assuming other problems come with the tolerance that are the REAL problem.

Anyway no idea where the idea comes from why anti-psychotics would work here, would be interesting to know if there is a merit or misunderstanding.. :)
 
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