I believe this is a very real possibility for some people.
Allergy has become a vague and misrepresented condition, I'll leave a medical expert to worry about the definition, but as fare as starting to have an adverse reaction to something exposure trigger this is some people. I have been told that I display atopic symptoms and have experienced adverse reactions to medications I have used for months or even years with out a problem.
A glimmer of hope though, the problems don't last and after a period of avoidance it seems the system is reset, not sure this is the same for all.