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Iodine, 2C-I, and the Thyroid Gland

fastandbulbous said:
All the shit about worrying about iodine-131 from things like the Chenobyl accident refers to iodine contained in soil ets as potassium/sodium/other metal ion iodides
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recently there was some excitement about iodine 131 and thyroid cancer, chernobyl was blamed despite the fact that the 131 from chernobyl has long since decayed, it would be almost totally gone in 3 months in three years the most sensitive detection systems wouldn't find it but it was still blamed for thyroid cancer in people born after 1988.

how much iodine is added to table salt?
 
I131 ia the slickest radiotherapy for any cancer out there. Is greater than 90% curative and washes out within 3 days. Note that I131 has a 3 day half life, making it also a favorite for radiolabelling assays since it does not need to be stored long before it is no longer hot.
I have a feeling that the bronchoconstriction is another mechanism since it happens to me with other PEAs, but to a lesser extent than 2CI.
 
General alcazar said:
I do not think that the iodine, esp a one time exposure, is of any significance unless one is allergic to it. However, 2CI consistenly causes bronchoconstriction for me (several different batches over the years). I have to keep an inhaler around, or it gets unpleasant, though never to the point where there is truely any danger of suffocating. I do not think this is a thyroid problem because my entire bronchial tree is affected.
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More than one person has complained of overproduction of very viscous mucous after taking 2C-I. This would feel like broncioconstriction, but not respond to antihistamines (only bronciodilators).

It has been occasionally reported with other 2C-x compounds as well, but 2C-I seems to be the worst offender
 
Used a few grams total of 2c-i over lets say.... a year about two years ago, have had no problems yet, thyroid functions fine. Real LONG term effects, nothing besides theories afaik, since it's relatively new.
 
Therories are based on known fact and it's a fact that without the aid of nitro-substituted aromatic systems on the ring as well as the iodine atom, the iodine is going to remain where it is. It will remain chemically bond to the 4 position of the phenyl ring, not forming free iodide atom.
 
I think that it is bronchoconstriction, not mucus, since there is no expectoration at all - in fact, if anything, airways are drier than usual. It feels very much like the beginning of an asthma attack, though it has yet to culminate in anything serious. I have not used 2CI in quite a while for this reason, however.. I'll probably revisit is occasionally once I have an inhaler on hand.
 
^^I also needed to have an albuterol inhaler on hand for my experiments with 2c-i. I didnt neccessarily have normal (chest tightness, bronchioconstriction, etc) asthma issues, I was just more prone get short of breath far more than normal from even minor physical activity. If I stayed in one place with minimal physical exertion, I would breathe fine.
 
fastandbulbous said:
Therories are based on known fact and it's a fact that without the aid of nitro-substituted aromatic systems on the ring as well as the iodine atom, the iodine is going to remain where it is. It will remain chemically bond to the 4 position of the phenyl ring, not forming free iodide atom.
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I remember reading an older paper (can't seem to find it now) that looked at DOI metabolism using a radiolabelled Iodine to trace the molecule. I believe it was given IV to primates.

If I remember correctly, 65% ish of the DOI was excreted unmetabolized. 3 other primary metabolites present in the animal's urine contained hot iodine, and brought the total to 98% of the iodine accounted for.

The authors speculated that the remainder of the radioactive Iodine had decayed before being identified due to its short half life, but the point is, in no instance did they find that the iodine had broken off the aromatic ring.

I can't see 2CI metabolism being really all that different from DOI metabolism.
 
The 2C group drugs seem to have a constricting effect on the chest(i have mild asthma and notice this every time as a slight persistant cough). this could easily account for a tightness in the throat.

The Iodine atom in 2c-i is well bonded, and as far as i know the other side groups on the ring will keep the charges in balance so it wont prefer to subsitute with other molecules. Otherwise you'd be getting some pretty poisonous free radicals floating round your body! Just think what it'd do if 2CI broke down and released I atoms free to attack your body! or Br atoms from 2CB.
 
hey, sorry to be reviving this thread after so long, but a friend had a question about whether she could take 2c-i with hypothyroidism, and i went about some research. she takes synthetic thyroxine and she was worried because she read an erowid report about thyroid problems (http://www.erowid.org/experiences/exp.php?ID=39567).

well, after some research, i came to the conclusion that 2c-i and HYPOthyroidism is NOT a dangerous combination (HYPERthyroidism is a different story, but with hyperthyroidism all stimulants should be avoided regardless)

after reading this paper:
http://www.ncbi.nlm.nih.gov/pubmed/16810648
this says that the iodine does not leave the benzene ring, and that the 2c-i metabolic pathway turns the methoxy groups into alcohols and then deamination. this leads to the conclusion that the body does not take iodine from 2c-i.

but what about thyroid interaction by the 2c-i molecule itself? this paper:
http://endo.endojournals.org/cgi/content/full/138/1/213
says to me that the deiodinase enzymes only work on iodine in the meta positions along with an alcohol in the para position, and will not deiodinate(?) with only one iodine atom on the ring. 2c-i has only one iodine atom on the ring, and its at the para position, not the meta, therefore it will not "fit" into the deiodinase enzyme.

further reading on thyroid/iodine interactions show that the thyroid only interacts with the reduced I-, not elemental iodine. i would not rule out any iodide impurities during a shitty synthesis/purification, but the pure product should contain less iodide than the maximum daily allowance.

my last argument is obviously my worst, but hypothyroidism can be caused by an iodine deficiency in the diet, so even if some of the iodine in 2c-i could be used by the thyroid, couldnt it possibly be a good thing?

keep in mind this only applies to HYPOthyroidism. and i would gladly welcome any criticism :)
 
It appears very unlikely that her medical condition will be exacerbated by the use of 2CI but isn't it safer just to choose a different material if there is any question at all? 2CI is slightly different to 2CB & 2CC but not sufficiently so to warrant undue risk.

While we are on this thread, I have always wondered about the 4 position being SF5. It's rather tricky to get it on there, which I assume is one reason that nobody has done it yet (AFAIK).
 
I have had asthma since birth, and I can honestly say, none of the 2c's that i've tried (2C-B, 2C-E, 2C-I), effect my breathing. I've tried 2C-I at 45mgs, and I was fine. I will say though, the stimulative effects everyone complains about, like a racing heart, does not effect me. Only minor muscle tension.
 
2C-I at 20mg dose gave me the most intense trip of my life. Afterwards it appeared like an allergic reaction (swollen face and hands to the point that it looked like i was going to pop)

Not fun. Dont know what caused it but I will not be taking any iodine containg compounds of this nature again.
 
^Then I would just point out that all table salt contains potassium iodide & the amount you would put on your fries will contain far more iodine than 20mg of 2CI. :D
 
^^sounds like an impurity, or something other than 2c-i. ive done 25mg and ive tripped way harder on shrooms, and never had that kind of reaction to 2c-i
 
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