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Iodine, 2C-I, and the Thyroid Gland

Morninggloryseed

Morninggloryseed

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So what is the real deal here? Everyone in the 'know' that I have talked with says the iodine at the para of 2,5-DMA and 2,5-DMPEA holds on tight, and never lets go. I can think of many pharmacueticals that have fluorine, chlorine, and even bromine...but I can not think of any that have iodine in their structure. Why is that? What do you folks here have to say about what is written below?

Iodine-containing molecules have an affinity for the thyroid, this being a sensitive vital organ weighing just one ounce. Thyroid hormones are iodized phenolic ethers of phenethylamines (such as Thyroxine, T4) and it is untested if 2CI disrupts the balances of thyroid hormones, or even damages the thyroid itself.

What is known is that users have reported sore thyroids after use of normal doses of 2CI

2CI (being a halobenzene) is a strong irritant (as proven by the excruciating pains when it is snorted) which may or may not be meaningful.

Then there is the iodine itself, which is attached ortho to a phenolic ether, being a position where it can break off the molecule with relative ease (compared to other RCs) and be substituted by something else, altering its properties.

Personally I believe that if one of the RCs would have important longterm adverse health effects, it might just be 2CI. I have been offered 2CI but declined it and advise others to do the same.
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morninggloryseed said:
What is known is that users have reported sore thyroids after use of normal doses of 2CI
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Oh? I've never seen this being mentioned before.

I do have elevated thryoid levels myself, but if it's due to the 2C-I, I highly doubt it.
 
The quote is not from me, and I as far as I am concerned...the information to nothing more than hearsay.. But I still wanted to run it by others.
 
Hah, I was just about to post asking why there are no benzodiazepines (that I know of) with iodine in their structure even though all other halogens are used.

Although thyroxin is synthesized from two iodinated tyrosine molecules, it is much larger and different-looking than 2C-I. I do not know how significant that is but it must have some SAR.

Also remember that table salt is usually iodinated, and many people take excessive ammounts daily. To my knowledge, execcive iodide salts inhibit thyroxine production, but the rates required for that are MUCH higher than what most people would consume in salt daily.

I do not see why 2C-I would be more dangerous, but then again I know so little.
 
The entire "iodine is never used in medicine" is a myth. If you'd like a list of some iodine containing medications, go here. Furthermore, iodinated radioisotopes are often used in radiology studies, and if there were a very serious problem with exposure to small emounts of iodine, I'm sure we would've heard about it by now.

Allergy to iodine is not a myth, however. The cases of problems in a minority of 2c-i users may actually been an allergic reaction.

For more information on radioiodinated compound studies and their safety, go here: http://radiographics.rsnajnls.org/cgi/content/full/24/suppl_1/S3

I would suspect that the number of people who have tried 2c-i is by now in the tens of thousands, if not more (it's popularity these days seems to be skyrocketing), and yet, there seem to be relatively few reports of health problems... I would doubt that the compound is all that dangerous.
 
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I never made such a claim (iodine is not used in medicine). If you look above, I said I could not think of any pharmacueticals that have iodine in their structure. My knowledge of pharmacueticals does not go much beyond sedatives, stimulants, narcotics, and a few odd substances containing indole in their structure. Oh, and I know a little bit about anti-biotics being an avid fish and bird keeper.
 
I'm not criticizing you specifically, but it's just an argument I hear a lot when people start talking about the dangers of 2c-i (probably spurred by that infamous erowid report on thyroid problems).

:)

(apologies for repetitive use of the second person)
 
I've tried 2c-i three times. Once by itself and twice at the tail end of a methylone experience. The first time I took it , I noticed a tightness in my throat the next day. It's possible that this could have been a psychological suggestion, though, since I'm a nursing major and know about the function of iodine in thyroid hormone synthesis.
 
Thyroxine type compounds have iodine in the 3,5-position with an OH/aryl ether at the 4 position. This is almost the reverse situation of the structure if 2C-I. As such, 2C-I will be unable to interact with the receptors that thyroxine based compounds do
 
smellyneohippy, what does a tightness in your throat have to do with your thyroid gland?
 
Comparison of structure of thyroxine & 2C-I.

As you can see, the iodine atom is at the wrong position on the aromatic ring in 2C-I to have any hope of acting like a thyroxine mimic (see att jpeg)
 

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Coolio said:
smellyneohippy, what does a tightness in your throat have to do with your thyroid gland?
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Your thyroid gland kind of wraps around your trachea.

Take a look:
 

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I wouldn't interpret a tightness in my throat as a thyroid issue, just as I wouldn't interpret a headache as brain damage or a stomach ache as an ulcer. I really doubt 2C-I's potential effects on the thyroid would cause a tightening sensation within the thyroid gland. My experience with a tightness in the throat sensation is that it's always due to intense vasoconstriction - psychedelics and stimulants do it, especially when I mix them with caffeine and/or nicotine.
 
My experience with a tightness in the throat sensation is that it's always due to intense vasoconstriction - psychedelics and stimulants do it, especially when I mix them with caffeine and/or nicotine.
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Eh? Vasoconstriction isn't in any way linked to a tightness in the throat. Other than mechanical injury to the trachea, it's nealy always due to the physiological response to anxiety (& 2C-I can cause some anxiety due to it's stimulant nature)
 
fastandbulbous said:
Thyroxine type compounds have iodine in the 3,5-position with an OH/aryl ether at the 4 position. This is almost the reverse situation of the structure if 2C-I. As such, 2C-I will be unable to interact with the receptors that thyroxine based compounds do
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Thank you :). That is exactly what I was hoping to hear when I made the above post.
 
I see a lot about that (2C-I thyroid interactions/problems), but thought it complete hooplah.

After looking into it even a little, I was pretty convinced that there wasn't anything to be concerned about.

I'm glad to see that a lot of people here hold the same views on it.
 
InsertSloganHere said:
I see a lot about that (2C-I thyroid interactions/problems)
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Another one. Care to mention where you've got this from? Because I've never seen it mentioned before. I'm curious about where they're creating new myths.
 
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