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Harm Reduction Intravenous Nicotine

Druidus

Druidus

Bluelighter
Joined
Mar 28, 2006
Messages
598
I have pure nicotine. I'd like to try an experiment with it, out of personal interest. I want to make a solution with it in water and administer it intravenously.

I'm well aware of the danger involved, both with injection and with the nicotine itself. However, I'm wondering how much I should use for one shot. I'm fairly sure I need to use an amount measured in micrograms, so as not to overdose. I've heard 50 micrograms might work. But I'd much rather see what info I get from the folks here in OD.

Thanks in advance - Also, if/when I do this, I will report back on the subjective effects I achieve with it.
 
I'm really interested to know how that would feel, if you end up doing it.
Although I must say, that I could easily imagine it being a bit dangerous. Especially because it would be very hard to know how much to use, since it is not at all a normally used ROA.
 
majorigpa said:
i inject heroin into my body everyday, but this sounds pretty extreme.
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That's nice, bro. Bet you enjoy it. I was addicted to high doses of intravenous opiates for years, too, myself.

Why? Just why?
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Curiousity, my friend.

I'm really interested to know how that would feel, if you end up doing it.
Although I must say, that I could easily imagine it being a bit dangerous. Especially because it would be very hard to know how much to use, since it is not at all a normally used ROA.
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Yeah, 'tis my main concern.
 
Im curious to get an ounce of blow and fuck a dead hooker but common sense tells me otherwise. That its not a good idea.

Some things are best left alone, yanno?
 
chase_in_56ace said:
One's life is a pretty stupid thing to lose for the sake of 'curiosity.'
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Nicotine has been administered intravenously in laboratory conditions before, and no one died because it was done right.

I intend to do this right, and I certainly intend to remain among the living.

I wouldn't even think of this if it hadn't already been done with no adverse effects.

As such, I will continue to explore that which incites my curiousity, including this.

Im curious to get an ounce of blow and fuck a dead hooker but common sense tells me otherwise. That its not a good idea.
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Injecting a safe amount of pure nicotine and engaging in coked-out necrophilic acts are two different ballgames, bro.

Some things are best left alone, yanno?
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True. The thing is, this CAN be done safely, I'm not the first to do it, and I see little reason not to try myself. Done at the right dose, it will not cause any issues.

I'm just trying to find out what the safe dose would be.



I'm aware of the risks, folks. I stated that in my OP. Regardless, I am capable of doing this without negative effects on my body or brain - IF I can find a good dosage.
 
Im sorry i cant comment on any harm reduction or dosage or anything but man this sounds insanely awful. Have you ever put a big fat dip or chew in and it was too much? I have and its very unpleasant overdosing on nicotine; you get really hot and start puking and feel really sick. I cant imagine having it all come on at once especially if you take a dose that is too large. It will be very unpleasent and possibly deadly.
 
DrugOmen said:
Im sorry i cant comment on any harm reduction or dosage or anything but man this sounds insanely awful. Have you ever put a big fat dip or chew in and it was too much? I have and its very unpleasant overdosing on nicotine; you get really hot and start puking and feel really sick. I cant imagine having it all come on at once especially if you take a dose that is too large. It will be very unpleasent and possibly deadly.
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I'm very aware of how unpleasant too much nicotine can be, and how easy it is to overdose. That's the entire reason I'm trying to find a good dose.
 
Alright, people, PLEASE, I don't need to hear about how this is dumb or dangerous. I KNOW it's dangerous, that's why I'm trying to do this as cautiously as possible.

As for it being "dumb", well, perceive it however you'd like. But administering the proper dose is safe (repeatedly tested in the process of experiments of IV administration of nicotine), and I would like to see what the subjective effects are like.

Sorry if you can't understand my motives here; but, really, that's not the point.
 
Inhalation isn't quick enough for you? Don't do it, nothing good will come out of this.
 
Dandiwer said:
Bad idea, just a bad idea.. These lab references you mention, what dose was used in those?
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It was a long time ago that I read about it, and I don't recall the doses mentioned.

I don't enjoy it, that was a harshly sarcastic way of perhaps making you realize what a pointless and dangerous dick-sizing mission you're about to embark on.
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I know well what you meant.

I decide whether there is a point to this for me, and I see one, regardless if others don't. I decide which dangerous risks to avoid completely, and in this case, I think the dangers can be mitigated.

And I resent the idea that this is some sort of "dick-sizing" endeavor. I'm not doing this to look "cool" or "hardcore", I'm doing this for my own purposes that have nothing to do with that.
 
Abstract
The subjective and physiological effects of intravenously administered cocaine and nicotine were compared in 10 cigarette-smoking cocaine abusers. Subjects abstained from smoking at least 8 h before each session. Under double blind conditions, subjects received placebo, cocaine (10, 20, and 40 mg/70 mg), or nicotine (0.75, 1.5, 3.0 mg/70 kg) in mixed order. Physiological and subjective data were collected before and repeatedly after each intravenous drug administration. Subjects also completed a drug versus money multiple-choice procedure in which they chose between that day's drug and 44 monetary values. Both drugs increased blood pressure and heart rate and decreased skin temperature. Nicotine showed a more rapid onset of subjective effects than cocaine. Overall, although both cocaine and nicotine increased subjective ratings of "drug effect", "rush", "good effects", "liking", "high", and "stimulated", only nicotine increased ratings of "bad effects" and "jittery". Although the highest nicotine dose produced greater effects than the highest cocaine dose on most subjective measures, the highest cocaine dose produced somewhat greater ratings of drug liking. At doses that produced comparable ratings of drug effect (40 mg/70 kg cocaine versus 1.5 mg/70 kg nicotine), cocaine produced significantly greater good effects, whereas nicotine produced greater bad effects. All three cocaine doses and the intermediate and high nicotine doses were frequently categorized as producing effects similar to those of cocaine or amphetamine. The drug versus money measure showed that the highest cocaine dose was worth twice as much as the highest nicotine dose. Thus, intravenous cocaine and nicotine can be differentiated by their subjective and reinforcing effects.
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http://www.ncbi.nlm.nih.gov/pubmed/9862770

Consistent with a shared dopaminergic mechanism of action, human laboratory studies examining intravenous administration of caffeine and nicotine suggest that they produce central effects similar to prototypically abused stimulants such as amphetamine and cocaine. Like intravenous cocaine administration, intravenous nicotine produces dose-related increases in various ratings of positive subjective effects (e.g., ratings of drug liking and high) and stimulant effect, as well as dose-related increases in heart rate and blood pressure in subjects with histories of drug abuse and cigarette smoking (Henningfield et al., 1985; Jones et al., 1999). Similarly, intravenous caffeine administration has been shown to produce dose-related increases in ratings of positive subjective effects, including drug liking and high, as well as increases in blood pressure in subjects with histories of drug abuse and caffeine consumption (Rush et al., 1995).
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Nicotine produced a dose-dependent increase in the frequency of stimulant identifications. When subjects identified a dose of nicotine as a stimulant, they usually (72%) further identified it as being cocaine and they never identified it as being nicotine. The high dose of nicotine was identified as a stimulant by all nine subjects. This dose was further identified as cocaine by seven subjects, as amphetamine by one subject, and as methylphenidate by the remaining subject. Although intravenous caffeine did not produce an increase in the frequency of stimulant identifications, caffeine was almost always identified as an active drug (e.g., stimulant, opiate, sedative, antihistamine). When subjects identified a dose of caffeine as a stimulant, they equally often (29%) further identified it as being cocaine or nicotine and never identified it as being caffeine.
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-http://jpet.aspetjournals.org/content/296/2/486.full


I remain intrigued.
 
Are you just bored, lacking real drugs, or are you honestly curious to experience IV nicotine? That idea has never even crossed my mind before.

I guess you'll see how it turns out then.
 
hangyourhead said:
Are you just bored, lacking real drugs, or are you honestly curious to experience IV nicotine? That idea has never even crossed my mind before.
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Not bored at all, really. I'm really enjoying my university courses right now.

I have all the "real" drugs I could want.

Yes, I am honestly curious about the subjective effects.

I guess you'll see how it turns out then.
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I suppose so.
 
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