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interesting mescaline analogue?

moracca

moracca

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Joined
Jul 16, 2005
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Anyone heard of or have any information on "C-(4,5,6-trimethoxyindan-1-yl)-methanamine"? It seems quite tasty from the abstract of the article.

A conformationally restricted analogue of mescaline, C-(4,5,6-trimethoxyindan-1-yl)-methanamine, was designed using a 5-HT2A receptor homology model. The compound possessed 3-fold higher affinity and potency than and efficacy equal to that of mescaline at the 5-HT2A receptor. The new analogue substituted fully for LSD in drug discrimination studies and was 5-fold more potent than mescaline. Resolution of this analogue into its enantiomers corroborated the docking experiments, showing the R-(+) isomer to have higher affinity and potency and to have efficacy similar to that of mescaline at the 5-HT2A receptor.
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any thoughts welcome
 
^thanks... I was thinking I might get a better response in ADD anyhow :)
 
very very interesting. oddly enough i was gonna post a similar thread but ima sit tight fo a response. OP is their anything more specific youd like to know?
 
this is sort of like the cyclobutyl mescaline analogues, which iirc, were even more potent.
 
this material might be around, as it was listed by a Chinese Contract Manufacturer, though who they made it for and whether they actually made rather than listing it, is anyones guess. don't bother PMing me for the name or a link.

This material appears to have been rationally designed based on the Nichols groups' model of the 5ht2a receptor, they designed it to fit the model rather than designing the model to fit the molecule.

it is not particularly potent but it is PLA2 mediated AA secondary messenger, The related 2,5 substitution pattern appears more potent again PLA2. The cyclobutanes are mostly PLC mediated IP turnover.
 
FrostyMcFailure said:
very very interesting. oddly enough i was gonna post a similar thread but ima sit tight fo a response. OP is their anything more specific youd like to know?
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mainly, I was wondering if there were any sort of human trials, whether anyone had any idea of neurotoxicity, stability, etc. I would like to know if the higher affinity for receptors translates into just lower dosages, or a vastly different experience altogether. Also wondering if the synth for this compound would be complicated (ie, too complicated to make it widely available)

vecktor said:
it is not particularly potent but it is PLA2 mediated AA secondary messenger, The related 2,5 substitution pattern appears more potent again PLA2. The cyclobutanes are mostly PLC mediated IP turnover.
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vecktor -- do you know whether this substance actually made its rounds, or if anyone got a chance to experiment? Also, I am not too savvy when it comes to the rest of your posts comments, but what impact do you think these facts could/do have?
 
Anyone know the effects of the corresponding amphetamine analog?
Thats probably a place to start.
 
Also wondering if the synth for this compound would be complicated (ie, too complicated to make it widely available)
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dont quote me on this since its just hunch but the work required for that maybe on par with LSD synth not counting obtaining highly illegal ingredients.

If this is the case very *very very very* few chemist looking to cook are going to choose a theorized(and mainly untested) mescaline analogue over LSD in the name of the people with a $$ trade off on something that may or may not produce effects; Maybe Tim scully owsley, nick sand.

The new analogue substituted fully for LSD in drug discrimination studies and was 5-fold more potent than mescaline.
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If this is true then it has been tested & successfully made. Im glad to read this if its true but mesc is usually a softer less jagged more loving type of trip to my exp.

& yes the amp analogue is probably the place to start.
 
FrostyMcFailure said:
If this is true then it has been tested & successfully made. Im glad to read this if its true but mesc is usually a softer less jagged more loving type of trip to my exp.
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nichols has made it, it substituted in rats. go read the paper.

& yes the amp analogue is probably the place to start.
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the alpha methyl group in the amphetamine congeners of the aminomethyl indans is redundant wrt to MAO resistance, it adds another chiral centre and another layer of complexity.
 
i was wondering, and i could be way off base here...

in standard tryptamines, the fact that both rings are aromatic adds to the molecule's stability, correct? Well the substance in question here, is much like one of those compounds, except the nitrogen atom of the indole ring is replaced with a carbon, therefor breaking the aromaticity of that ring. Does this adversely impact molecule stability?

Again, if i'm way off, please let me know. I'm still learning :) Thanks
 
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