Interestig effect

[New]

I am currently taking ziprazadone, escitaprolam and trazadone as neccesary, ad I'm noticing an unusual effect concering DXM. I still receive the euphoria and sense of well being from it, I, just, the dissociation seems to be a non issue when I take DXM under those medications. I was wondering if any of you guys could extrapolate a solution to why i get half the effects, but not the other half, you know what i'm saying?

and for those who aren't walking PDR's, Gedon, Lexapro fir ziprazodone and escitaprolam.

 

[LuxEtVeritas]

just off the top of my head as a general answer one or more of those drugs is antagonizing that pathway(s) that produces that component of its effect it appears

perhaps ZIPRA via NMDA or TRAZ as a 5-HT2 receptor antagonist

also can maybe be via liver enzyme competition i guess

 

[MattPsy]

I would look toward enzyme inhibition - DXM's metabolism to DXO may be affected by these meds.

 

[New]

Thanks guys, that makes sense,

 

[hussness]

Ziprazadone is DA antagonist, and escitalopram is a high affinity 5-HT reuptake inhibitor. This would explain diminished effects from DXM, but not the subjective lack of NMDA antagonism. Enzyme inhibition would be a good avenue to check out, but I don't have the information yet.
I've noticed that about 6 months after I turned 22 DXM stopped having any effect on me. I've racked my brain and tried temporarily eliminating medications from my system that might mess with the DXM-DXO conversion, but nothing has worked.

 

[Pothedd]

during the process of dxm extraction i believe it's converted into dxo. you could consume it as pure dxo so your liver doesn't have to convert it. from what i understand it's much more intense that way. i'd like to try it maybe.