Opioids Interaction between Buprenorphine and SR-17018

[jack_flash]

Hello people,

I'm on buprenorphine 10mg at the moment, and I want to do an extra with another opioid soon (U47). I saw that SR-17018 could help reduce tolerance and cravings. I was wondering if:
- If I replace the buprenorphine for a few days before taking the other opioid do I need to wait to be in withdrawal of bupre to take the SR?
- Do I need to wait to take the U47 after starting the SR to be able to feel the opioids effects?
- When I'm done with the U47, can I take the SR right away or do I need to wait to be in withdrawal (like with bupre)?
- Can I take bupre right away after the SR or same do I need to wait to be really sick in withdrawal to be able to take the bupre?

Thanks for your anwsers!

 

[helpingout]

SR is a research chemical and I don’t think has undergone human trials. 4DQSAR might be able to help with a study. You should send them a pm and ask them to take a look at your post. They’re very good at finding resources but you’ll need to do the reading yourself. Hopefully they’re able to help you as they’re extremely knowledgeable

 

[jack_flash]

Just did, thanks a lot for your suggestion. Let's hope I can find an answer to those questions, especially the one where I ask if I can take bupré quickly after SR

 

[4DQSAR]

They will compete for receptor occupancy and buprenorphine has a much higher affinity.

You are aware that the originators of buprenorphine only trialled it's use in detoxification for 7-14 days, right?

Take it for a week and stop, it works as well as anything the grey market is shilling right now.

Take if for years - you are dependent ON buprenorphine. The right drug has existed since 1970 - it's usage however has been perverted. Not much profit in something a client only takes for 7-14 days. I was told by a member of Bentley's team that the 'optimal' hop-off point was the moment the client is stabalized on whatever dose of buprenorphine they needed. The amount did not seem key. It was all about arrestin recruitment. Once that is fixed, stop.

HOWEVER - 90% of clients with opiate use disorder will go back to opioids within 12 months. So I suppose the logic is that it's safer for a person to be dependent on buprenorphine than street drugs.

How safe IS buprenorphine? We don't know - a single 2009 study exists showing a small mortality rate but since then, not one person is keeping track of just how safe buprenorphine really is.

I truly believe that given the complexity of the SR-17018 (the patent and a full breakdown of the costs is posted by me, somewhere) is just the Chinese practice of 殺豬盤. I don't know the price people are paying but the safety paradox means that some people mistakenly assume that the current price and availability will remain. Well, by my calculations if it costs less than about $200/g, even the cheap Chinese are only making it at cost.

I compated it to cychlorphine due to structural similarity then noted that while SR took five steps and gives 19.2% yield, for cyclorphine, it's two steps and around 54% total yield. I even costed out the time, equipement, reagents, solvents, absorbants and so on. I feel it is a compelling bit of evidence but as always, I provided a link to the patent, explained how to calculate overall yield and just noted that one cost about x1000 than the other on a per-dose basis.

Let's face it, if a 'magic pill' just ended all the risks of opioid addiction, it WAS buprenorphine. But not used as it is now. At least with buprenorphine you don't have to play the 'what is in the mystery powder' game.

But that's how I see it. A loss-leader so more people are comfortable with getting a habit which is then served by the much more profitable analogue. Right now the stuff is likely OK, but who can say what the future holds? At least the price of buprenorphine won't suddently go up by 10000% or become unavailable.