intense and fast reaction to Prozac

[pokerboy]

Hi everyone,

A few months ago I was prescribed a small daily dose of prozac for mild depression (10mg/day). It didn't do much, I felt better after a couple of weeks so I stopped.

A few days ago, I had a mephedrone experience where I took about 400mg over 5 hours in small lines. I had a bad reaction at the last line where I felt overly stimulated and confused for about 12 hours, then it wore off slowly. I felt quite depressed (I also ran out of weed a week ago and was coming down of that) so I took a 20mg prozax pill 48h after the meph. Now I had read everywhere that prozac takes weeks to become effective... but on that instance it was very fast: after a few minutes I felt very stimulated and my mood improved dramatically! What the hell happened? Why was it so fast and intense?

(PS I realize self medication is bad)

 

[Hiltoniano]

You have acclimated once to it, when you took it the first time. Your brain can more easily revert to the state that was induced once you took it daily for a while.

 

[Doctor_Ew420]

^ Yeah, or it was a placebo effect or the simple effect of recovering from the mephedrone.

I dated a girl who was on prozac and she stopped for a period of time, weeks later she started again. She had to go through the whole 'shitty ecstasy' feeling for a few days before it started working again. Everyone is different... maybe the prozac did help (but who cares if it did really... You got the effect that you were looking for, same reason I still take echinacea even though there is no proof it helps to kill a cold *but it does!*)

 

[pasha]

Much like any other stimulant can raise blood levels of any ssri or snri the same may have happened here. Prozac takes weeks so it can build up effective blood levels in the system, you were just able to induce this process temporarily. Some evidence suggests that mephedrone has a half-life of under 20 hours and given that it takes several half-lives to completely rid your system of any drug, chances are you took the prozac while the mephedrone was still in your system but not active.

I've had a similar experience where my psychiatrist started me on methylphenidate shortly after putting me on prozac. I was pleasently surprised to have the same positive effects you're describing once I took the methylphenidate until its elimination half-life, hence why a stimulant and an ssri or snri is a very popular combination in psychiatry. However I advise that you do not practice this combination unless you are under a doctors supervision as both can lower the seizure threshold and taking an excess amount of stimulant can raise the blood levels of an ssri or snri to the point of serotonin syndrome which can be fatal.