Yawning Angel
Greenlighter
- Joined
- Jul 17, 2010
- Messages
- 11
I humbly submit the below for your constructive criticism before I begin to disseminate
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N20 has been used for over 170 years and it's safety has been established, most notable danger is the (serious) ability to absolutely devastate your B12 levels should you not supplement with it proactively.
www.ncbi.nlm.nih.gov
www.ncbi.nlm.nih.gov
however there are plenty of ways to mess yourself up with it, as with most substances use not abuse, respect your body and the substance!
Here are some more appropriate non nuclear tips if your going to use N20.
1) Take B12 supplements. Methylcobalamin. Do not pass go. Do not skip this step. Get your ass on amazon and order this now. 2) CLEAN UP AFTER YOURSELF. Do not dump empty whippets. These are steel and recyclable. I don’t care if a dolphin wont choke on it, your fellow citizens will think less of nitrous users everywhere thanks to your lazy ass if you don’t!/
3) Do it from a ballon, or LET THE DISPENSER WARM UP well after you crack it (10-15sec minimum) and take at low pressure. Frostbitten lungs suck and the charger holds the gas at 3 x atmospheric pressure.
4) Be aware of the pressure danger on your lungs taking it from a dispenser, balloons are safest but loading them can be loud. Respect your neighbours.
5) DO IT SITTING OR LAYING DOWN. Don’t let someone do it standing unless they are +10 lev pro. DO NOT HAND THE CRACKER TO A NOVICE AND LET THEM TRY IT STANDING, YOU ARE RESPONSIBLE FOR THEIR INJURY!
If a friend DOES try it standing or insist, get behind them ready to catch them. I’ve caught 4+ people counting. Each one can be a death with a head hit in the wrong place.
6) Best Brand / Filter for residue / clean cracker regularly (All of the above sunshine!)If your going to do more than 100 in a few day period, get the best brand possible Isi professional (purple), Ultrapure, Isi, Mosa. That order (subjective!) and use your t-shirt over the cracker dispenser! Clean the inside of the dispenser regularly and be aware of the residues and cold and the effect of both on your lungs. The residue is oil used in the injection/manufacture process. The new Isi professional purple chargers are WAY cleaner, like unbelievably so, but more expensive. You can filter pretty well with a layer of cotton fabric (i.e. your t-shirt etc) DO NOT DO NOS WITHOUT DOING THIS. Erowid tested this and it eliminates over 90% of the residue/oils. Take it from a long time user, your lungs will appreciate this, be diligent about it.
7) Take B12 and some folic acid! Yes, this is point 1 as well. Don’t skip it bitch. (not together, b12 and folic acid next day. L-Methoine may also be an advanced asset here)
Nitrous oxide inactivates the cobalamin form of vitamin B12 by oxidation. Symptoms of vitamin B12 deficiency, including sensory neuropathy, myelopathy, and encephalopathy, can occur within days or weeks of exposure to nitrous oxide anesthesia in people with subclinical vitamin B12 deficiency.
DO NOT SKIP THIS POINT, you can end up with spinal degradation, temp or longer (permanent if your a fucking NOB who wont listen to your body and stop). If your a real NOS head take liquid b12 shots or level up and learn how to do intramuscular injections of B12, learn about whats going on. Medscape article about occupational exposure of nitrous on dentist assistants and midwifes is a goldmine. Methionine might also help your DNA synthesis continue (a good thing, trust me)
8) Take several deep and fast breathes before doing the nitrous. Take some nitrous, and some air. Don't hyperventilate into a balloon for as long as you can! Don't hold your breath for as long as you can. The nitrous interupts the normal C02/oxygen flow and you can hold you breath a lot longer than normal without the normal urges. Danger this way lies my friend. 20 secs is good. Longer is danger.
Rebreathing the nitrous in a balloon is useless. It's mostly absorbed first breath. Respect your bodies requirement for oxygen. The displacement of air from your lungs with an inert gas can dull the sense of NEEDING to breath. Approach it like free-diving or Wim Hof method. Pre load with oxygen.
9) Oh and if your doing 'doubles' or two chargers worth at once: Lay down and have a trip sitter. Nitrous very temporarily restricts bloodflow to extremities and your blue lips while laying unresponsive on the floor can be distressing to others and event security.
Ask yourself if doing this on the side of the dance floor is really worth it or whether a trip of this intensity (however brief) is perhaps best done is a safe, comfortable place with your friends watching over each other.
So, why you may ask, do people do chargers? Because when on psychedelics they act as a temporary amplifier, magnifying the trip by several multiples for 30-60secs, gifting some absolutely gorgeous visual and auditory hallucinations and deep personal revelations and fading away with an anaesthetic like body glow which is very pleasant. This can also make alcohol suddenly VERY UNPLEASANT. Alcohol and Nos don’t work well. It can also make mushrooms or other exotic recreational chemical suddenly very instense. BE AWARE, Look out for you mates!
However this strong effect can be used for good. Someone who is having a sideways trip can sometimes be knocked into a fresh path by a charger of NOS. Sharing is caring. No one is attracted to a NOS fiending crack whore of charger hog. I know they’re fun, let it go, they don’t get better and you can get more later. The friends you make could be for life ;-)
As with everything, responsible, respectful imbibing is key. Same goes for alcohol, tobacco and all recreational substances. Don't be a burden on those around you. Don't spread misinformation. Be a source of harm reduction to your friends and those around.
http://justsayn2o.com/nitrous.donts.html
“Nitrous oxide is thought to be relatively harmless. It is only addictive in the psychological sense - in the same way that theme park rides or cheeseburgers are addictive because we like the effects they produce - and it isn't poisonous. Nevertheless it has produced at least one death from asphyxiation - if your lungs are full of nitrous oxide, you aren't getting any oxygen - and the way that a small amount of the gas can render someone semi-conscious makes it easy for a user to get into danger.”
https://www.chemistryworld.com/podcasts/nitrous-oxide/3005880.article
Bonus for those doing hundreds a day. Day after day. Ok this is next level and getting into abuse rather than use. You need to not only be very on the B12, you MUST take breaks of many days between such sessions or risk various effects including unusually high methylmalonic acid and homocysteine levels as well as risking motor neuropathy or neuronopathy which is no joke. See below studies. Be honest with yourself Inject b12 and realise this drug has a huge potential for psychological addition (not physical, no withdrawals!)
Methionine depletion is also implicated in the neurological deficit which has been clearly shown to be a complication of chronic nitrous oxide abuse.
www.ncbi.nlm.nih.gov
...
onlinelibrary.wiley.com
www.ncbi.nlm.nih.gov
Random unsorted bonus notes for geeks below Other practical methods might reduce the amount of residue in the output stream, such as placing a loose cloth inside the WCM, though this could propel cloth fibers into the output. A long, flexible tube on the WCM output nozzle might capture more of the residue and/or lower gas velocity enough to reduce the amount of inhaled particles.
all traces of the gas are excreted from the body within an hour after cessation of use
Nitrous oxide will dissolve out of blood into air filled spaces eg the intestines, the middle ear. N2O in the gut will just give you a gut pain, but if you have ever had middle ear disease, or damaged ear drums, you could be in for permanent hearing loss. There are also some cases of transient hearing loss, but I don't know much about this.
methylcobalamin is B12
This is almost certainly the cause of the megaloblastic anaemia and leucopaenia which follows prolonged administration, and it could well explain the foetotoxic effects of nitrous oxide
Methionine depletion is also implicated in the neurological deficit which has been clearly shown to be a complication of chronic nitrous oxide abuse.
en.wikipedia.org
en.wikipedia.org
Markers such as deoxyuridine suppression (dU-suppression), red cell folate, serum folate, Vit B12 and homocysteine levels have all been used to monitor for effects of N2O exposure as well as direct measurements of MS activity. Serum Vit B12 seems to be unaffected by N2O exposure. Studies have shown a good link between depletion of MS activity and both serum homocysteine levels and increased rates of dU-suppression and in the recovery of both to normal levels. These are generally the preferred markers of Vit B12 deficiency.
Because of that detoxification process, cyanocobalamin usage could potentially deplete glutathione (GSH), an important anti-oxidant that helps decrease lipid peroxidation associated with oxidative stress. Once glutathione stores are depleted, high dose cyanocobalamin might theoretically cause cyanide toxicity, especially in renal failure patients.
Because of that detoxification process, cyanocobalamin usage could potentially deplete glutathione (GSH), an important anti-oxidant that helps decrease lipid peroxidation associated with oxidative stress. Once glutathione stores are depleted, high dose cyanocobalamin might theoretically cause cyanide toxicity, especially in renal failure patients.
Also, some people may have clinical or sub-clinical conditions which inhibit them from being able to convert this form of B12 to the active forms, and eventually absorb it. In these cases, you will see your serum B12 levels increased (it counts both active and inactive B12), but you’ll have a functional deficiency of AdeCbl and MetCbl in tissues and other body fluids.
Besides, it takes more than 48 hours for cyanocobalamin B12 to eventually convert to usable methylcobalamin, and even then
Thus, it became apparent that N20 impairs DNA-synthesis through inactivation of the cob(1)alamindependent enzyme methionine synthase, which catalyzes the methylation of homocysteine in the generation of methionine under simultaneous demethylation of methyltetrahydrofolate to tetrahydrofolate (THF) (Fig. 1). Deficiency and inactivation of methylcobalamin both lead to a functional deficiency of folates by the “trapping” of metabolically formed methyl-THF and by the decreased potential of utilizing plasma folate, which is transported as methyl-THF after intestinal absorption [l l-131. N,O may provoke subacute combined degeneration of the spinal cord in vitamin B,-deficient subjects [ 141. Analogous neurological complications have followed interrupted N,O breathing in addicted dentists [15] and continuous exposure in cynomolgus monkeys
pdfs.semanticscholar.org
www.bluelight.org
-------------
N20 has been used for over 170 years and it's safety has been established, most notable danger is the (serious) ability to absolutely devastate your B12 levels should you not supplement with it proactively.
New Evidence of Enhanced Safety of Nitrous Oxide in General Anesthesia - PMC
www.ncbi.nlm.nih.gov
Nitrous Oxide is an Effective and Safe Anesthetic - PMC
www.ncbi.nlm.nih.gov
however there are plenty of ways to mess yourself up with it, as with most substances use not abuse, respect your body and the substance!
Here are some more appropriate non nuclear tips if your going to use N20.
1) Take B12 supplements. Methylcobalamin. Do not pass go. Do not skip this step. Get your ass on amazon and order this now. 2) CLEAN UP AFTER YOURSELF. Do not dump empty whippets. These are steel and recyclable. I don’t care if a dolphin wont choke on it, your fellow citizens will think less of nitrous users everywhere thanks to your lazy ass if you don’t!/
3) Do it from a ballon, or LET THE DISPENSER WARM UP well after you crack it (10-15sec minimum) and take at low pressure. Frostbitten lungs suck and the charger holds the gas at 3 x atmospheric pressure.
4) Be aware of the pressure danger on your lungs taking it from a dispenser, balloons are safest but loading them can be loud. Respect your neighbours.
5) DO IT SITTING OR LAYING DOWN. Don’t let someone do it standing unless they are +10 lev pro. DO NOT HAND THE CRACKER TO A NOVICE AND LET THEM TRY IT STANDING, YOU ARE RESPONSIBLE FOR THEIR INJURY!
If a friend DOES try it standing or insist, get behind them ready to catch them. I’ve caught 4+ people counting. Each one can be a death with a head hit in the wrong place.
6) Best Brand / Filter for residue / clean cracker regularly (All of the above sunshine!)If your going to do more than 100 in a few day period, get the best brand possible Isi professional (purple), Ultrapure, Isi, Mosa. That order (subjective!) and use your t-shirt over the cracker dispenser! Clean the inside of the dispenser regularly and be aware of the residues and cold and the effect of both on your lungs. The residue is oil used in the injection/manufacture process. The new Isi professional purple chargers are WAY cleaner, like unbelievably so, but more expensive. You can filter pretty well with a layer of cotton fabric (i.e. your t-shirt etc) DO NOT DO NOS WITHOUT DOING THIS. Erowid tested this and it eliminates over 90% of the residue/oils. Take it from a long time user, your lungs will appreciate this, be diligent about it.
7) Take B12 and some folic acid! Yes, this is point 1 as well. Don’t skip it bitch. (not together, b12 and folic acid next day. L-Methoine may also be an advanced asset here)
Nitrous oxide inactivates the cobalamin form of vitamin B12 by oxidation. Symptoms of vitamin B12 deficiency, including sensory neuropathy, myelopathy, and encephalopathy, can occur within days or weeks of exposure to nitrous oxide anesthesia in people with subclinical vitamin B12 deficiency.
DO NOT SKIP THIS POINT, you can end up with spinal degradation, temp or longer (permanent if your a fucking NOB who wont listen to your body and stop). If your a real NOS head take liquid b12 shots or level up and learn how to do intramuscular injections of B12, learn about whats going on. Medscape article about occupational exposure of nitrous on dentist assistants and midwifes is a goldmine. Methionine might also help your DNA synthesis continue (a good thing, trust me)
8) Take several deep and fast breathes before doing the nitrous. Take some nitrous, and some air. Don't hyperventilate into a balloon for as long as you can! Don't hold your breath for as long as you can. The nitrous interupts the normal C02/oxygen flow and you can hold you breath a lot longer than normal without the normal urges. Danger this way lies my friend. 20 secs is good. Longer is danger.
Rebreathing the nitrous in a balloon is useless. It's mostly absorbed first breath. Respect your bodies requirement for oxygen. The displacement of air from your lungs with an inert gas can dull the sense of NEEDING to breath. Approach it like free-diving or Wim Hof method. Pre load with oxygen.
9) Oh and if your doing 'doubles' or two chargers worth at once: Lay down and have a trip sitter. Nitrous very temporarily restricts bloodflow to extremities and your blue lips while laying unresponsive on the floor can be distressing to others and event security.
Ask yourself if doing this on the side of the dance floor is really worth it or whether a trip of this intensity (however brief) is perhaps best done is a safe, comfortable place with your friends watching over each other.
So, why you may ask, do people do chargers? Because when on psychedelics they act as a temporary amplifier, magnifying the trip by several multiples for 30-60secs, gifting some absolutely gorgeous visual and auditory hallucinations and deep personal revelations and fading away with an anaesthetic like body glow which is very pleasant. This can also make alcohol suddenly VERY UNPLEASANT. Alcohol and Nos don’t work well. It can also make mushrooms or other exotic recreational chemical suddenly very instense. BE AWARE, Look out for you mates!
However this strong effect can be used for good. Someone who is having a sideways trip can sometimes be knocked into a fresh path by a charger of NOS. Sharing is caring. No one is attracted to a NOS fiending crack whore of charger hog. I know they’re fun, let it go, they don’t get better and you can get more later. The friends you make could be for life ;-)
As with everything, responsible, respectful imbibing is key. Same goes for alcohol, tobacco and all recreational substances. Don't be a burden on those around you. Don't spread misinformation. Be a source of harm reduction to your friends and those around.
http://justsayn2o.com/nitrous.donts.html
“Nitrous oxide is thought to be relatively harmless. It is only addictive in the psychological sense - in the same way that theme park rides or cheeseburgers are addictive because we like the effects they produce - and it isn't poisonous. Nevertheless it has produced at least one death from asphyxiation - if your lungs are full of nitrous oxide, you aren't getting any oxygen - and the way that a small amount of the gas can render someone semi-conscious makes it easy for a user to get into danger.”
https://www.chemistryworld.com/podcasts/nitrous-oxide/3005880.article
Bonus for those doing hundreds a day. Day after day. Ok this is next level and getting into abuse rather than use. You need to not only be very on the B12, you MUST take breaks of many days between such sessions or risk various effects including unusually high methylmalonic acid and homocysteine levels as well as risking motor neuropathy or neuronopathy which is no joke. See below studies. Be honest with yourself
Inject b12 and realise this drug has a huge potential for psychological addition (not physical, no withdrawals!)
Methionine depletion is also implicated in the neurological deficit which has been clearly shown to be a complication of chronic nitrous oxide abuse.
Severe motor neuropathy or neuronopathy due to nitrous oxide toxicity after correction of vitamin B12 deficiency - PubMed
This case illustrates that N2 O-associated severe motor neuropathy or neuronopathy can develop separately from typical vitamin B12 deficiency dorsal column myelopathy. This syndrome can present when functional measures of vitamin B12 deficiency have normalized.
www.ncbi.nlm.nih.gov
Vitamin B12 Deficiency: What It Is, Symptoms & Treatment | Chris Kresser
B12 deficiency can cause depression, fatigue, and other serious problems. Find out more about what this vitamin does and learn how to correct a deficiency.
chriskresser.com
Error - Cookies Turned Off
Myeloneuropathy from nitrous oxide abuse: unusually high methylmalonic acid and homocysteine levels - PubMed
A 23-year-old patient developed diffuse paresthesias and sensory loss. He had mildly reduced serum vitamin B12 (B12) concentration with unusually high levels of methylmalonic acid (MMA) and homocysteine and no evidence of B12 malabsorption. Following parenteral B12 administration, his...
www.ncbi.nlm.nih.gov
Random unsorted bonus notes for geeks below Other practical methods might reduce the amount of residue in the output stream, such as placing a loose cloth inside the WCM, though this could propel cloth fibers into the output. A long, flexible tube on the WCM output nozzle might capture more of the residue and/or lower gas velocity enough to reduce the amount of inhaled particles.
all traces of the gas are excreted from the body within an hour after cessation of use
Nitrous oxide will dissolve out of blood into air filled spaces eg the intestines, the middle ear. N2O in the gut will just give you a gut pain, but if you have ever had middle ear disease, or damaged ear drums, you could be in for permanent hearing loss. There are also some cases of transient hearing loss, but I don't know much about this.
methylcobalamin is B12
This is almost certainly the cause of the megaloblastic anaemia and leucopaenia which follows prolonged administration, and it could well explain the foetotoxic effects of nitrous oxide
Methionine depletion is also implicated in the neurological deficit which has been clearly shown to be a complication of chronic nitrous oxide abuse.
Methylmalonic acid - Wikipedia
Methylmalonic acidemias - Wikipedia
Markers such as deoxyuridine suppression (dU-suppression), red cell folate, serum folate, Vit B12 and homocysteine levels have all been used to monitor for effects of N2O exposure as well as direct measurements of MS activity. Serum Vit B12 seems to be unaffected by N2O exposure. Studies have shown a good link between depletion of MS activity and both serum homocysteine levels and increased rates of dU-suppression and in the recovery of both to normal levels. These are generally the preferred markers of Vit B12 deficiency.
Because of that detoxification process, cyanocobalamin usage could potentially deplete glutathione (GSH), an important anti-oxidant that helps decrease lipid peroxidation associated with oxidative stress. Once glutathione stores are depleted, high dose cyanocobalamin might theoretically cause cyanide toxicity, especially in renal failure patients.
Because of that detoxification process, cyanocobalamin usage could potentially deplete glutathione (GSH), an important anti-oxidant that helps decrease lipid peroxidation associated with oxidative stress. Once glutathione stores are depleted, high dose cyanocobalamin might theoretically cause cyanide toxicity, especially in renal failure patients.
Also, some people may have clinical or sub-clinical conditions which inhibit them from being able to convert this form of B12 to the active forms, and eventually absorb it. In these cases, you will see your serum B12 levels increased (it counts both active and inactive B12), but you’ll have a functional deficiency of AdeCbl and MetCbl in tissues and other body fluids.
Besides, it takes more than 48 hours for cyanocobalamin B12 to eventually convert to usable methylcobalamin, and even then
Thus, it became apparent that N20 impairs DNA-synthesis through inactivation of the cob(1)alamindependent enzyme methionine synthase, which catalyzes the methylation of homocysteine in the generation of methionine under simultaneous demethylation of methyltetrahydrofolate to tetrahydrofolate (THF) (Fig. 1). Deficiency and inactivation of methylcobalamin both lead to a functional deficiency of folates by the “trapping” of metabolically formed methyl-THF and by the decreased potential of utilizing plasma folate, which is transported as methyl-THF after intestinal absorption [l l-131. N,O may provoke subacute combined degeneration of the spinal cord in vitamin B,-deficient subjects [ 141. Analogous neurological complications have followed interrupted N,O breathing in addicted dentists [15] and continuous exposure in cynomolgus monkeys
[PDF] Ant i-Leu kem ic Potential of Met hy I-Cobalam in Inactivation by Nitrous Oxide | Semantic Scholar
Combining the anticobalamin activity of N,O with an anti-folate seems to be a promising chemotherapeutic approach for suppressing leukemia. Myelo-cytotoxicity of extended nitrous oxide (N,O) inhalation was described almost forty years ago and then incidentally applied already with temporary...
pdfs.semanticscholar.org
Inhaling oil contaminants in nitrous oxide chargers?
It seems many people are having issues with machine oil contamination of nitrous oxide chargers. We wonder how much of this is actually inhaled when inhaling with various means, what the significance of this may be, and how to reduce inhalation of oil. Perhaps transferring the gas from a whip...
www.bluelight.org
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