Information on MPPP ???

[lordreven333]

I have been looking for information on MPPP but can't find much MPPP also known as Desmethylprodine.Any information would be greatly appreciated

 

[nAON]

Why, may I ask? Isn't that the opiate that, should it have a slight impurity, will give you parkinsons disease and destroy portions of your brain?

 

[Oxide]

MPPP was synthesized in 1977. It's not used clinically, but instead recreationally. It's a demerol analogue, and can indeed form the impurity MPTP, which causes the onset of parkinson's disease.

Here is an excerpt on MPTP from the MPPP wikipedia page:

However, the intermediate tertiary alcohol is liable to dehydration in acidic conditions if the reaction temperature rises above -30°C, and, since Kidston did not realize this and esterified the intermediate with propionic anhydride at room temperature, MPTP was formed as a major impurity.[3] Several days after trying this new batch of his homemade drug, Kidston developed serious Parkinson's Disease symptoms, as did several friends he had shared the drug with.[4]
1-Methyl-4-phenylpyridinium (MPP+), a metabolite of MPTP, causes rapid onset of irreversible symptoms similar to Parkinson's Disease.[5][6] MPTP is metabolized to the neurotoxin MPP+ by the enzyme MAO-B, which is expressed in neurons. This selectively kills brain tissue in the area of the brain called the substantia nigra and causes Parkinsonian symptoms