Increasing MAO-A

[Broshious]

Does anyone know any way of increasing amounts of MAO-A? Or decreasing Serotonin some other way?

 

[MattPsy]

Inhibit tryptophan hydroxylase or decarboxylase or a similar strategy.
Not sure why you'd want to do that but... (nor am I sure of inhibitors for said enzymes)

 

[Broshious]

I believe that I may have too much Serotonin rather than a lack thereof. Yeah, I was thinking about inhibiting Tryptophan Hydroxylase. I know MDMA has that effect, but I don't know how much of an effect is has nor how long it lasts. I think I'd want to leave the decarboxylase alone as it is involved in dopamine production as well.

 

[Jamshyd]

What leads you to believe you have "too much serotonin," if I may ask?

 

[Broshious]

What leads you to believe you have "too much serotonin," if I may ask?

Nothing concrete. Just a theory of sorts. My personality type has been linked to having higher levels of 5-HT, and I figured I'd try lowering it for say a week and see what happened.

 

[Jamshyd]

As I mentioned in many other threads here dealing with neurotransmitters here, I will say it again:

The idea of simply associating a neurotransmitter with a personality trait/mood is very innacurate pharmacologically. I don't know where it originated, but I believe it was probably the marketting strategies employed by pharma companies that sell SSRIs.

Your personality, thought, feelings and all are affected by the electric currents that are the result of the sum total of ALL the chemical changes in your brain happening all the time. It can never be narrowed down to one chemical.

ps. If you indeed have "too much serotonin", your personality would be the last thing you'd worry about, because chances are you'll be throwing up, having a stroke, AND a heart attack all at once, that is, if you didn't burn yourself up by generating too much heat! .

 

[nuke]

You could try tianeptine (SSRE). Increasing the expression of MAO-A is seemingly difficult.

 

[LuxEtVeritas]

^^^

good call, even if the simplicity of one neuroT is as stated above is not really the correct way to look at things due to th high degree of complexity of the whole system

but some LOVE Tianeptine, so he may wish to give a try there

 

[Broshious]

You could try tianeptine (SSRE). Increasing the expression of MAO-A is seemingly difficult.

I've tried Tianeptine and it did seem like it worked okey. Problem I had was abusing it =P Not to mention it is expensive as fuck.

 

[nuke]

What about tryptophan-5-hydroxylase inhibitors? (eg, MDMA, p-EPA)

MDMA should inhibit it with an acute dosage of say 50-60mg once a week. Neurotoxicity is an issue with this drug, though, and your serotonin levels might be permanently damaged.

You should be able to get someone to manufacture p-EPA for relatively cheap overseas or where ever, it's basically like selegiline but for T-5-HO rather than MAO-B. Relatively untested AFAIK though. It'd be used once a week for this purpose too, probably.

paper on p-EPA: http://www.ncbi.nlm.nih.gov/sites/e...ez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum

 

[Broshious]

What about tryptophan-5-hydroxylase inhibitors? (eg, MDMA, p-EPA)

MDMA should inhibit it with an acute dosage of say 50-60mg once a week. Neurotoxicity is an issue with this drug, though, and your serotonin levels might be permanently damaged.

You should be able to get someone to manufacture p-EPA for relatively cheap overseas or where ever, it's basically like selegiline but for T-5-HO rather than MAO-B. Relatively untested AFAIK though. It'd be used once a week for this purpose too, probably.

paper on p-EPA: http://www.ncbi.nlm.nih.gov/sites/e...ez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum

Thanks. I'd never heard of p-EPA before. Would it be orally active? I had considered MDMA, but as I have no access to it, and it has quite a few other effects than just Tryptophan Hydroxylase I am hesitant.

 

[bigmac74]

As I mentioned in many other threads here dealing with neurotransmitters here, I will say it again:

The idea of simply associating a neurotransmitter with a personality trait/mood is very innacurate pharmacologically. I don't know where it originated, but I believe it was probably the marketting strategies employed by pharma companies that sell SSRIs.

Your personality, thought, feelings and all are affected by the electric currents that are the result of the sum total of ALL the chemical changes in your brain happening all the time. It can never be narrowed down to one chemical.

ps. If you indeed have "too much serotonin", your personality would be the last thing you'd worry about, because chances are you'll be throwing up, having a stroke, AND a heart attack all at once, that is, if you didn't burn yourself up by generating too much heat! .

The whole process is simply know as "dumbing down"...
It's a way of communicating things that take years of studying and earning a degree for to the general public, who want simple basic explanations for everything.

As for "too much serotonin", as most people would know, the body tries to maintain homeostasis, so obviously you won't be throwing up/suffering the effects of serotonin syndrome just because your personality seems to fit the 'too much serotonin whatever thingy theory'. If you were producing too much serotonin, your body counteract to maintain homeostasis.

 

[Broshious]

The whole process is simply know as "dumbing down"...
It's a way of communicating things that take years of studying and earning a degree for to the general public, who want simple basic explanations for everything.

As for "too much serotonin", as most people would know, the body tries to maintain homeostasis, so obviously you won't be throwing up/suffering the effects of serotonin syndrome just because your personality seems to fit the 'too much serotonin whatever thingy theory'. If you were producing too much serotonin, your body counteract to maintain homeostasis.

Yes, yes. Lets just say I think if I were to reduce my 5-HT levels it MAY be beneficial, and as it is entirely reversible I don't see any reason why not to TRY it.

 

[Jamshyd]

The whole process is simply know as "dumbing down"...
It's a way of communicating things that take years of studying and earning a degree for to the general public, who want simple basic explanations for everything.

Duumbing down is one thing, presenting as fact is another. The latter can lead people to do very dangerous things, for example, taking MDMA weekly or abusing Tianeptine because they think they "have too much serotonin".

As for "too much serotonin", as most people would know, the body tries to maintain homeostasis, so obviously you won't be throwing up/suffering the effects of serotonin syndrome just because your personality seems to fit the 'too much serotonin whatever thingy theory'. If you were producing too much serotonin, your body counteract to maintain homeostasis.

I know - that was sarcasm. What I am saying is that Broshious' self-diagnosis of "too much serotonin" is erroneous, if for nothing then because the body does maintain homeostasis wrt serotonin levels.

Broshious, I would believe you have a problem, but I am telling you right now that your problem is not having too much serotonin. PLEASE do not abuse Tianeptine or MDMA, and PLEASE don't mess with your MAO system - you will only cause yourself more problems.

Yes, yes. Lets just say I think if I were to reduce my 5-HT levels it MAY be beneficial, and as it is entirely reversible I don't see any reason why not to TRY it.

How on earth would messing with your body's natural balance be benificial? And besides, where in your brain do you plan on increasing serotonin? An increase in one area would have results that would be the opposite of increasing it in another.

Please, just don't.

ps. Tianeptine does not simply "decrease serotonin levels". From what we know about it, it simply increases its reuptake - so you will have the same ammount of serotonin, just inside the cells rather than outside of them. This all goes to prove that the idea of increasing or decreasing serotonin has effects on mood is very wrong.

 

[Adrenochrome]

Before you do anything stupid I recommend you look into seeing if there's any blood tests to check these levels or if there's any urine tests