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Increase serotonin receptor sensitivity

chem_novice

chem_novice

Greenlighter
Joined
Mar 28, 2007
Messages
8
I'm not sure if this question has been answered before, I'd be surprised if it hasn't.

From my understanding, when a compound like MDMA has been administered, serotonin floods the synaps and the neurons natural response it to down regulate the 5-TH receptors.

I want to find out if it is possible to increase the receptor sensitivity, or up regulate the receptors to make the same amount of MDMA more effective.

My idea is to reduce the neurotoxicity, reduce comedown and shorten the recovery period by using less MDMA to do the same job.
 
making serotonin receptors more sensitive wont reduce neurotoxicity, if things turn out to be like they are on mice, antioxidants will reduce this damage and slow a tolerance
altough from new studies we know that the same neurotoxic damage as in rats does not seem to occur in humans by measering SERT

in my knowledge there is only one compound that has been shown to make serotonin receptors more sensitive, inositol

i gotta look that study up again
 
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Please do, that is incredibly interesting when you consider that many cocaine dealers utilize inositol as the main cutting agent. Maybe there is more to it than just the similarity in appearance and texture.

Cocaine does release serotonin, perhaps inositol is potent enough to change the experience qualitatively for the user?
 
However, chronic inositol induced a significant increase in striatal D(2) receptor density with a slight, almost insignificant, increase in 5HT(2) receptor density. This suggests that D(2) receptor upregulation may play an important role in the behavioral effects of inositol although the role of the 5HT(2) receptor in this response is questionable.

hmm remember an other study on serotonin only
 
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there is more tough, i also remember something about releasing serotonin causes inositol to get released (from what i understand, could have been talking about something totally differend), and as it makes receptors more sensitive it may play a big role in tolerance
if only i could find all studies again
 
another note, its interesting that a few bumps of k seem to eliminate comedown from what i've read
an nmda antagonist also seems to prevent tolerance to opiates and amphetamines
 
I found this but it is gibberish to me:

Myo-inositol reduces serotonin (5-HT2) receptor induced homologous and heterologous desensitization.

The effect of myo-inositol was examined on 5-HT2 receptor mediated facilitation of NMDA depolarization of rat neocortical neurons in vitro. Myo-inositol (1-10 mM) potentiated the 5-HT facilitation, the potentiation increasing linearly with log 5-HT concentration. Myo-inositol also eliminated 5-HT induced heterologous desensitization of muscarinic and alpha 1-adrenergic receptor mediated facilitation. Our findings suggest that 5-HT induced homologous and heterologous desensitization results in part from depleting phosphoinositide substrate.

If anyone can tell me what that means in English(if anything) that'd be great.
 
It seems my idea jumped the gun here. From reading some further research on inositol I can gather that oral dosages of 2 to 20 grams per day are used to help treat depresion. It took several weeks for mood lift to apear with results equally effective as several SSRIs! With those kind of dosages needed orally on a daily basis it seriously doubt a bit of inositol up the nose could have much of an effect.

medieval, the effect of K on comdowns and tolerance is very intriguing to alot of us. I think it warrants its own thread actually. My best guess is that the effect is due to some downstream action (not a very specific statements huh). I would love to see some serious research in this area.
 
^ there are already threads on K and other NMDA antagonists and amp tolerance/ reverse tolerance sensitisation.
you could resurrect one of those.
 
theWorldWithin said:
It seems my idea jumped the gun here. From reading some further research on inositol I can gather that oral dosages of 2 to 20 grams per day are used to help treat depresion. It took several weeks for mood lift to apear with results equally effective as several SSRIs! With those kind of dosages needed orally on a daily basis it seriously doubt a bit of inositol up the nose could have much of an effect.

medieval, the effect of K on comdowns and tolerance is very intriguing to alot of us. I think it warrants its own thread actually. My best guess is that the effect is due to some downstream action (not a very specific statements huh). I would love to see some serious research in this area.
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brining the magic back seems anecdotally possible with piracetam or aniracetam, the problem is that even on this stuff tolerance will still develop, so its only back the first few times

i asked my doc to presicribe me piracetam yesterday (its prescription here) i will test if it brings the magic back for me, once its back i will take some ketamine everyime i use E, and also take this big doses of inositol (if i can find it here)

i take MDMA weekly, i'm very interested to see if it brings the magic back and if it will stay
 
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MeDieViL said:
also take this big doses of inositol
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Depending on what you mean by big doses of inositol you can get pretty massive diahhrea so just be aware.

Also with regards to losing the magic I wonder if propranolol might not have an effect as it supposedly helps people forget traumatic events. It has been mentioned numerous times that perhaps part of the loss of magic is the loss of the novelty of MDMA so reducing the significance of those memories could perhaps work?
 
perhaps part of the loss of magic is the loss of the novelty of MDMA so reducing the significance of those memories could perhaps work
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i dont beleive in that theory as piracetam for example has brought the magic back for some ppl anecdotally
 
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Tianeptine might help, might make you sick in combo though. I bet it'd be a great day-after pill, though
 
ah damn, just remember that ketamine and the racetams dont interact well!

^^ i dont think it will slow tolerance, but i know it will potentiate mdma, dont know if it could be a dangerous combo
 
actually its rather easy to test if ketamine would block a tolerance
use ketamine when you take E, and keep taking e like 2 days in a row

if at the end your still rolling, ketamine blocks tolerance ;)
 
MeDieViL said:
i asked my doc to presicribe me piracetam yesterday (its prescription here) i will test if it brings the magic back for me, once its back i will take some ketamine everyime i use E, and also take this big doses of inositol (if i can find it here)
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i tried piracetam for a few days and it definatly did bring the magic back if i only take a normal morning dose of piracetam, taking lots of piracetam a few hours before my roll doesnt seem to work as well, i dont know why
i did not bring the "wave" back tough, i beleive that is not a problem because of serotonin sensitivity but because of serotonin depletion, i will experiment with 5HTP in the future
 
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