[In]activity of LSM-775 in Humans

[LibertasMentis]

Firstly I hope this thread is placed in the right section, I think it constitutes ADD material but if not please do move it to the relavent board.

I have recently been given the opportunity to sample several rare lysergamides, here I will discuss my experience with d-lysergic acid morpholide. I received a small quantity of material in crystalline form, it is a fine white 'fluffy' powder. The stucture was confirmed by NMR and LCMS, so I beleive what I have is infact enantiomerically pure d-LSM. There are only a couple of studies on LSM, both of which date back to the 50's. The two studies I found had conflicting conclusions, one suggests that LSM is one-tenth as active as LSD, whereas another states that LSM requires a third greater dose than that of LSD. I have quoted excerpts from both studies at the bottom of this post.

Given this information I decided to make a solution of LSM in EtOH with a concentration of 1mg per ml (50mcg per drop). I kept this in the freezer for around 3-4 days before dosing. I initially dosed 50mcg orally as an allergy test. An hour past and I felt nothing so I consumed another 200mcg, after 30-40 mins I could feel something vagley representing an ergoline. After another hour it had not developed further so I took another 200mcg bringing my total upto 450mcg. Again not much happened, the same slight 'acidy' feeling was felt, in fact I felt a little uneasy if anything. Some very faint visuals were noticed but nothing more than slight movement of shadows. I was very dissapointed and slept after 6 hours from the initial dose.

Some weeks past and I read through the studies again, I noticed an interesting comment in Gogerty and Dille's paper that I must have missed before. They stated the follwoing.

Work in this laboratory indicates that in more concentrated solutions this substance will remain stable for only three to four hours whereas in dilute solution (400 to 600 micrograms per ml) the stability is maintained for approximately 7 days.

My solution could indeed be considered 'concentrated' so I gave it another whirl with freshly prepared solution. This time I dosed 500mcg orally, after 20mins I could definitely feel something, similar to the previous experiment but perhaps slighly more. After an hour, it had developed no further so I dosed another 500mcg. Some time past and although this odd vaguely 'acidy' feeling was certainly present it had not developed into anything mildly interesting. I did notice some visuals at the 'peak' but only very minor ones, perhaps similar to 50mcg of LSD.

All in all I am dissapointed this compound didn't show any potential, I was expecting something more from it. However saying that there have been no recent human assays, all I had to go off was these rather ancient research papers. It does still make me wonder though whether the material I consumed had epimerised after the initial analysis was done, or perhaps I'm just thinking wishfully.

Any input would be much appreciated, I was wondering if anyone has any experience with this compound? I've seen various posts here on Bluelight stating that it is very similar to LSD just requiring a higher dose.

Pharmacology of d-lysergic acid morpholide (LSM), John H. Gogerty and James M. Dille (1957).

The pharmacological effects of d-lysergic acid morpholide (LSM) are similar to those of LSD.

The dose of LSM required to raise body temperature in the rabbit is three times as great as that of LSD and the effect is of shorter duration.

On the isolated rat uterus LSM is approximately 1/12 as effective as LSD in antagonizing 5- hydroxytryptamine.

The behavioral effects of LSM in animals are similar to those of LSD but the doses required are approximately 1/3 greater and the effects are of shorter duration.

In human beings (2 volunteers) the effects of LSM were qualitatively similar to those of LSD but the dose required was at least 1/3 larger and the duration of action was shorter.

Relationships of Psychotomimetic to Anti-Serotinin Potencies of Congeners of LSD-25, Harris Isbell (1959).

Gogerty and Dille (1957) found that 75mcg (total dose) LSM-775 induced short-lasting effects in 2 subjects, which seemed equivalent to those following 50mcg of LSD. In contrast, we found LSM-775 to be approximately one-tenth as active as LSD.

 

[golden1]

Just thought I'd add, redosing LSD after you start to feel the effects never seems to add nearly as much as I'd expect compared to dosing it at once. Thats the first thing I thought of in your trials is that you spread the doses out which for me with LSD would probably result in similar diminished effects.

 

[LibertasMentis]

Very true but you'd expect it to show a lot more at 500mcg in one dose if it was going to hold potential.

 

[Incunabula]

I seem to remember reading that some blotters that went around in Europe couple of years back were tested positive in containing LSM. Supposedly very similar to LSD, but with a shorter duration.