CosmicG
Bluelighter
It has been quite some since festivalman posted. Whats up with it?
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Immense depression after 2 day roll
- Thread starter Festivalman1
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dippindots
Ex-Bluelighter
- Joined
- Dec 7, 2014
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- 6
I used to take 5-HTP after rolling….friend told me it's a precursor to serotonin, therefore, taking an 5-HTP supplement will help replenish depleted serotonin. After blindly following his advice for a few months, I decided to research 5-HTP's efficacy myself, and after reading this article, I'll never touch the stuff again.
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3415362/
The take-home message is that serotonin and dopamine use the same transporter, so increasing serotonin synthesis will deplete dopamine. Best to let your brain recover on its own. Hang in there.
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3415362/
The take-home message is that serotonin and dopamine use the same transporter, so increasing serotonin synthesis will deplete dopamine. Best to let your brain recover on its own. Hang in there.
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The maintenance of physical heath is underrated. If one is undergoing depression from mdma, then exercise. For real.
http://www.mayoclinic.org/healthy-living/fitness/in-depth/exercise/art-20048389
And of course, think positive, eat well, sleep 8 hours a day, take vitamins, abstain from substances, go get a check up, etc.
Doing all this will fix most people's issues on this board. Just help yourself.
http://www.mayoclinic.org/healthy-living/fitness/in-depth/exercise/art-20048389
And of course, think positive, eat well, sleep 8 hours a day, take vitamins, abstain from substances, go get a check up, etc.
Doing all this will fix most people's issues on this board. Just help yourself.
It's hard to compare studies conducted in depressed people to those who have just binged with MDMA. MDMA is the most powerful serotonin releasing drug we have discovered. Not only this but it inhibits the bodies natural route of producing serotonin. So actually 5-HTP, theoretically (nobody has studied it properly), is useful as a short-term aid to an MDMA comedown. But I agree that as a long-term treatment for depression or in any other context 5-HTP is likely to do nothing, especially without carbidopa.
That's not technically true.
This is nothing to do with transporters on neurons but instead the enzymes which produce things in our body. They're basically saying there's a ceiling effect to how much of a neurotransmitter the brain can produce and by increasing 5-HTP more serotonin is produced meaning less dopamine is produced. It's kind of like a set size tank of production for all of three catecholamines (5-HT, DA & NE). The body in equilobrium would produce the suitable amounts but by flooding with 5-HTP serotonin is over-produced effecting the amount of the others.
dippindots
Ex-Bluelighter
- Joined
- Dec 7, 2014
- Messages
- 6
"The synthesis, metabolism, and transport of serotonin and dopamine, along with their amino acid precursors, are primarily controlled by the functional status of transport, which is carried out by organic cation transporters (OCT). Serotonin, dopamine, and their amino acid precursors must be transported by OCT across cell walls. Transport dominates, controls and regulates synthesis and metabolism. Administration of 5-HTP alone leads to increased unbalanced transport of serotonin. Competitive inhibition at the transporters will inhibit movement of dopamine and its precursors into areas that affect synthesis and metabolism, compromising and depleting dopamine (catecholamine) levels."
"Additionally, a previous study reported that in animals 5-HTP caused increased turnover of both dopamine and norepinephrine. They hypothesized that 5-HTP is taken up by catecholaminergic neurons, transformed into 5-HT that, in turn, could act as a false transmitter, possibly increasing the turnover of catecholamines. 'The net functional result of the two opposite processes, ie, formation of a false transmitter and increased synthesis of catecholamines, is unknown. In other words, it is unknown whether 5-HTP augments or reduces catecholaminergic neuronal functions.'"
I can understand the logic and see the appeal of using 5-HTP to replenish serotonin after MDMA (or other serotonergic drug) use, but emphasis on "nobody has studied it properly", and vitamins/ supplements do have potential to cause harm. I, personally, take large doses of vitamin C for the antioxidant properties, but I know for certain that it's harmless. Is it helping? Maybe a little, maybe not, but it isn't causing any harm. 5-HTP, on the other hand, may be causing more harm than good. We just don't know, so it seems irresponsible to be advising people to use it. Just my 2c.
"Additionally, a previous study reported that in animals 5-HTP caused increased turnover of both dopamine and norepinephrine. They hypothesized that 5-HTP is taken up by catecholaminergic neurons, transformed into 5-HT that, in turn, could act as a false transmitter, possibly increasing the turnover of catecholamines. 'The net functional result of the two opposite processes, ie, formation of a false transmitter and increased synthesis of catecholamines, is unknown. In other words, it is unknown whether 5-HTP augments or reduces catecholaminergic neuronal functions.'"
I can understand the logic and see the appeal of using 5-HTP to replenish serotonin after MDMA (or other serotonergic drug) use, but emphasis on "nobody has studied it properly", and vitamins/ supplements do have potential to cause harm. I, personally, take large doses of vitamin C for the antioxidant properties, but I know for certain that it's harmless. Is it helping? Maybe a little, maybe not, but it isn't causing any harm. 5-HTP, on the other hand, may be causing more harm than good. We just don't know, so it seems irresponsible to be advising people to use it. Just my 2c.
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Deleted member 337748
Bluelighter
- Joined
- Sep 18, 2014
- Messages
- 499
the more a person abuses mdma the prone a person becomes to episodes of depression and even long term depression.
Wouldn't it also depend on the person too?
Most people around me never had serious depression from mdma even from heavy abuse. I'm very surprised it affects as many people as it does. I've seen depression from other "natural" events, like a death of a family member, huge problems in general, drama with friends and stuff like that.
Though I do realize that is one of mdma's negative effects as it relates to serotonin depletion. And the fact that everyone's mmv. I think naturally induced happiness goes a long way for mdma's mood recovery. I have seen people go through comedowns and feel like crap immediately or a day or two after rolling, but myself and others can snap him/her out of it pretty easily.
One of the worst things that can happen to some people is if they go through their problems alone. Being there for someone usually works wonders for anyone mildly depressed.
Most people around me never had serious depression from mdma even from heavy abuse. I'm very surprised it affects as many people as it does. I've seen depression from other "natural" events, like a death of a family member, huge problems in general, drama with friends and stuff like that.
Though I do realize that is one of mdma's negative effects as it relates to serotonin depletion. And the fact that everyone's mmv. I think naturally induced happiness goes a long way for mdma's mood recovery. I have seen people go through comedowns and feel like crap immediately or a day or two after rolling, but myself and others can snap him/her out of it pretty easily.
One of the worst things that can happen to some people is if they go through their problems alone. Being there for someone usually works wonders for anyone mildly depressed.
MasterSplinter
Bluelighter
bro i find this is mostly common when you rollin on a good night sum beans is not as good enough and you end up having to take one more, okay, then you take a few more than when you finally rollin on your peak you dont even know how good for even in the first place when they hadnt got there.
Ecpesially when there are girls bringing out lines and you end up doin one two many but hey at least the sex is great,
Some lightweights feel werse effexcs but you can move past it, if you. Then Just make sure to eat some good vegetables and fruit while you exercise for a coupledays maybe one or two and you should be good to roll again in a month.
Ecpesially when there are girls bringing out lines and you end up doin one two many but hey at least the sex is great,
Some lightweights feel werse effexcs but you can move past it, if you. Then Just make sure to eat some good vegetables and fruit while you exercise for a coupledays maybe one or two and you should be good to roll again in a month.