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IM salvinorin A from 100X extract?

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psood0nym

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How much more dangerous than intramuscularly injected medical-grade DMSO and smoked salvia would the following concoction be:100X standardized salvia extract (100X to minimize plant residue) stirred in 50% DMSO, drawn into a 30 gauge syringe as a 1st crude filtering, then filtered through a 10 um micron filter, and then heated to a boil before IM injection? I ask because I don’t see any IM salvinorin A reports, nor do I see what is significantly more dangerous about the proposed DMSO/salvinorin A solution compared to using its components separately beyond the presence of extraordinarily small amounts of sterilized plant constituents in the latter (much of which I assume would be dissolved by the DMSO). Salvinorin A is soluble in as low as a 50% DMSO solution. DMSO has been intramuscularly injected into people to treat tinnitus and does not seem to cause significant discomfort or side effects. IM salvinorin would likely offer access to the visionary state that most people cannot reach through the use of tinctures while at the same time allotting sufficient time to analyze and reflect on the experience in a way that smoking precludes. It seems like this route of administration would be the best for experiencing salvia’s full potential. Has anybody seen reports on this? I assume I must be missing some crucial fact here that accounts for their absence.

What do you think the dose would be for a +++? 1-1.5mg?
 
i would think trying to draw into a 30G would be crazy and something lower would still more than suffice for a crude pre-filter type process

assumably you would have little to worry about with a proper protocol as outlined, however perhaps best to try to score some pure Salv A which i believe is available and save the trouble and worry

DMSO is wholly safe
 
1 to 1.5mg??? shit, with 100X I dunno if you'll be conscious for most of your experience.

I wonder how quick it'll hit.
 
Well you have obviously thought this through (I was thinking of IMing and using DMSO as a carrier)

Is this 100x Salvia or pure Salvinorium A, because the two are not the same. 1mg would be about the right dose to start with and I would think it would hit harder and faster than smoking. Which is why I decided not to do it in the end since smoking it is enough for me atm.
 
I'd start with a quarter mg to start with. Can always go up, but if you overdo it, you'll wish you hadn't.

I'm not so sure it'll hit quicker than smoking. It'll likely take longer IM, actually.
 
let us know how it goes

as someone else said, try to order pure salvinorin A

differences in your experience would not only reflect MOA, but also the fact that when you smoke or tincture salvia there are probably a number of psychoactive compounds besides salvinorin A. a 'pure salvinorin A IM' trip report would be interesting, as well as a 'salvia 100X IM' trip report for comparison
 
About 5 or 6 months ago I managed to get some pure salvinorin B. Useless.

in tandem, though, who knows.
 
A bit OT, but does anyone know if Salv A or any other psychoactive substances besides DMT leave the user in an IMPROVED brain state neurochemically speaking

obviously most rec substances leave the brain in a compromised state to one degree or another, but DMT is noted to actually have a positive effect from what i have read

TIA...
 
and speaking of pure compounds from S. Divinorum this would be interesting to have isolated

Possibly Salvia contains other psychoactive substances, as reported by Valdés III. He discovered that a substance called divinorin C, chemically closely related to salvinorin A, might be active at an even lower dosage, but this has not been tested on humans. Other compounds in Salvia possibly contribute to the psychoactive effects, but only the psychoactivity of salvinorin A has been proven.
 
Ham-milton said:
I'd start with a quarter mg to start with. Can always go up, but if you overdo it, you'll wish you hadn't.

I'm not so sure it'll hit quicker than smoking. It'll likely take longer IM, actually.
Click to expand...

IM is noticably slower than either smoking or IV administration (moreso with more lipophilic compounds) - this might actually be a good thing for salvinorin A as I've found using the buccal/sublingual route much more user friendly & useful than the 'flash, bang, wallop' you get from smoking it ( too far, too fast; sometimes way too far, way too fast!).


Is this 100x Salvia or pure Salvinorium A
Click to expand...

If you assume that ordinary leaf contains 2.5mg of salvinorin A per gram of leaf material then pure salvinorin A is the same thing as x400 concentrate.

Injecting plant materials (with their foreign proteins) can cause an allergic reaction & even possibly anaphylactic shock. If you don't know how to prepare a pure sample of salvinorin A, you could be risking your life doing this
 
Good advice guys. I agree that pure salvinorin A would be preferable, but all the components I mentioned using in the OP are just what I already have on hand. The 1-1.5 mg mark for salvinorin A would be ~4-6mg of 100X I believe. I agree that IM should have a slower onset and be slower acting, but I can only make vague guesses about the actual profile. Given that tolerance isn't an issue with it, it would be easy to prepare a full 1.5mg and just inject a small percentage and then wait to see if more should be used. In my opinion the best experience with salvia would probably be attained using around the suggested dose preceded by a low dose of ketamine to act as a buffer to the distracting/dysphoric somatic effects of salvinorin A (though ideally it should be explored alone first). I do plan to do this eventually, probably within a month or two, but the main reason I asked is just because I thought it was strange that there's no reports using the suggested method despite the fact that this possibility is available to pretty much anyone. Would've expected Siebert to do it. Well, not stopping anyone else... bear in mind the anaphylactic shock comment. Just how little plant protein is likely to cause anaphylactic shock? Anyone know?
 
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Standardized extracts have salvinorin A reconstituted on the surface of the leaves. Salvinorin is soluble in as low as a 50% concentration of DMSO.

As far as allergic reactions are concerned, I've actually had a "needle rack" full of different allergens pressed onto my back as a child as a test for allergies. Though the injections were merely subcutaneous, I don't imagine the total amount of potential allergens extracted into DMSO from a few mgs of salvia 100X is that different from the amount used in those tests (in other words, it seems you'd need to be highly allergic to the proteins to have a significant reaction beyond localized swelling). Not trying to rationalize the safety of this or anything, it just seems potentially relevant.
 
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^^dont be shy with the details, I've been contemplating this myself, just with 99.8% salvinorin, no extracts
 
I have gotten pretty pure salvinorin A out of 100x by separating some on glass with 99% alcohol.
I have taken 20 or 30 mgs and dissolved it in a cap full of alcohol and poured it on to a large piece of glass or mirror and let dry. Usually there will be a good separation of salvinorin A, wax, and chlorophyll matter. 100x is usally 25% salvinorin A and 75% wax and plant matter, the salvinorin A is the heaviest thing in there so it will settle out first in the middle of the puddle. Then you can scrape up the small white crystals. If you start with a good cold extract you should be able to get small amounts of close to pure (96%?) salvinorin A crystals. That is not the best most professional way to isolate some salvinorin A but it is cheap easy and fast.

I have played with 2 different extracts a warm and a cold they had the same amount of salvinorin A but the cold was much cleaner. Warm extracts seem to pick up some tar or oils from the plant matter that a harder to separate.
 
^

Yes one should get almost 100% Pure Salvinorins which is 96% Salv A and 4% Salv B and the Salv B simply is at that level (and I believe far higher) inactive as is known
 
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