I'm no MDMA enthusiast but how would this drug behave metabolically compared to MDMA?

[/navarone/]

Cleavin is alwas an issuo in drug metabolism. And cleaving of the methyele-dioxy is, for the most part, he cause of MDMA toxicity due to alpha-methyldopamine endogenesis.

So how would this drug behave instead? Would there be so much ease of cleaving the dioxy ring before it gets excreted?

 

[/navarone/]

Ops, I thought I posted this in ADD, could a mod move the thread please?

 

[Oxide]

Sure thing, moved.

 

[sekio]

The N-desmethyl version of this is known, if memory serves addition to the methylene group on the MD ring serves to greatly decrease activity.

 

[Repulse]

Wouldn't this potentially be a pro drug for MDMA? Those two CH3's sticking out on the propylidenedioxy-part yells "open for metabolic business", or rather "open for metabolic cleavage" to me..
(I'm not sure if the second statement was sexual on intention or not.. LOL)

 

[sekio]

No.

 

[/navarone/]

Yeah I found the article sometime later, a Difluoromethylenedioxyamphetamine analog was also created while reaserching for a non toxic MDMA substitute though not much testing has been done.
Something tells me it would be an even more aggressive serotonergic blaster.....which is definitely not a good idea.

I think I'll just wait for 3,4-difluoroamphetamine to hit the RC market and see (by studies and reports) how it compares with MDA, effect-wise and toxicity-wise.

 

[nuke]

I'm not sure it would be very active... That's a pretty massive amount of steric hindrance flying out of that ring (basically a valine side chain, which is huge in atomic terms).