I'm almost convinced my prescribed klonopin are placebos.

[behindblueeyes]

Now, I take them as prescribed... daily... I usually take between 1.5-2mg a day. Right now I'm at the point of just taking them for fear of withdrawal, because they do nada for my anxiety symptoms anymore. Took them to help with alcohol withdrawal... still had fast beating heart, shaking, tremors, and anxiety so bad I was ready to check myself in an ER.

Today, I had a very bad anxiety moment, and I had to go get my car inspected and was so afraid of having a panic attack in front of people, I took 2.5 mg. Did nothing, although I managed to hide my shaking panic. I think it's about time I get off these bitches.

Never take them daily for a long period of time! This is what happens.

 

[alt 14]

What's your question again?

Doctors can't prescribe take-home placebos, afaik.. Against ethics. Sounds like tolerance. If that answers your question?

 

[Corazon]

in your OP you described different reasons for usage and different dosages. You also implied that you drank large amounts of alcohol along with them.
All these things can multiply the already serious problems with long term use. I hope things get better with you and you find some consistency. Talk to your doctor.

 

[behindblueeyes]

Sorry, I left out the question... yes, it was a tolerance based question... my anxiety is still the same whether I'm on them, or not... and I am gonna talk with my dr. about coming off them.

 

[twotoomany]

Clonazepam isn't a good benzo for acute panic attacks in my non-medical opinion. It can take up to four hours to reach peak plasma levels. Alprazolam usually reaches peak effects in one hour, and can be felt even sooner.

It's a good one to taper with though. I've been tapering down for a month or so, from 1mg/day to .125mg every other day. I was only taking them for about 6 months though. They really helped with my anxiety, but my doctor will only give me 15 .5 mg a year unless I'm willing to try an antidepressant for my anxiety, which I'm not. Good luck getting off em!

 

[alt 14]

To the guy that only gets 15 pills a year, you can ask your doctor about buspar? I'm on it and ill admit it doesn't "feel" like anything, and its impossible to abuse, but I forget I even used to have anxiety. I have many other mental issues though and this doesn't fix em all, but something you can look into for sure.

 

[behindblueeyes]

To the guy that only gets 15 pills a year, you can ask your doctor about buspar? I'm on it and ill admit it doesn't "feel" like anything, and its impossible to abuse, but I forget I even used to have anxiety. I have many other mental issues though and this doesn't fix em all, but something you can look into for sure.

I'm curious about the buspar thing too. I've heard a lot of bad stories about it though...do you take an antidepressant with it?

 

[alt 14]

Naw, I'm on anti-psychotics though. And one of the reasons he chose it was because I got ED as a side-effect of them, and apparently it can combat that.

Also I think my dick is like at least 1-1.5 inches shorter than I remember it being in high school, but I haven't measured lately to check. Like from 7 to what now looks to me to be 6 or less, but I feel like I'm not gettin all the way hard. So I might need to hit him up on the cialis/Viagra script he offered. Not to gross anyone out, but if you're getting it for that reason as well, beware it might not live up to the hype.

P.S. with buspar it's something you have to take all the time, and it never really "kicks in," but slowly, like slower than you can be aware of ime, it will handle mild-moderate anxiety, until you eventually just don't think about it. Won't help with panic attacks and all that, but good for long-term issues. Least for me

 

[T. Calderone]

One thing with buspar is you're really not supposed to drink alcohol with it. It was not an option for me, since my liver enzymes were real high. I've known people that found this medication to be very helpful though. I have heard different things too, like it acts on serotonin, and not the same as a benzo would work. Talk to your doctor and see what he thinks about buspar.

 

[alt 14]

Really?? This alcohol thing is news to me. I kinda wish the doctor would have said something specifically to me about it if it turns out to be true.. He knows I drink on a decently regular basis Well I was when I was originally prescribed it anyway

 

[bennyZA]

That's what happens, tolerance is a bitch. I was taking tons and tons of klonopin a day and I couldn't even feel 10mg by the end.

 

[hatrix]

I have been prescribed Xanax, Klonopin and Valium.

In my opinion, I could never really "feel" the klonopin, and wasn't on it very long. It tasted the best lol, but it was so mild and not effective against my anxiety. So I've chosen Valium for now and am satisfied with it. It doesn't punch me in the face when taking before daily tasks like Xanax would, and lasts a long time. Still kicks in very fast for stimulant comedowns too and has better muscle relaxant properties.

Try switching benzos if you want to still stay on them.

 

[Jktm]

I was at one point Rx'ed 4mg of clonazepam a day, and after a while, I found that no amount would help my anxiety. It's absurd the amount of clonazepam I can take and receive no effect (any benzodiazepine at this point, now). I now get 6mg of alprazolam (Xanax) a day now, and I find it to help a lot more, though because of abuse in the past of benzos, Fioricet, and alcohol, even this amount leaves me anxious, but keeps me pretty level. Combining these with alcohol use or when used with other benzos, Lyrica (pregabalin)/Neurontin (gabapentin), Soma (Carisoprodol), GHB or barbiturates (Fioricet (Butalbital w/ tylenol+caffeine and sometimes codeine) and phenobarbital are the only ones really used these days) will dramatically increase your tolerance to whichever benzo you normally use.

And no, it is unwise to mix buspar with any anti-depressant.

 

[alt 14]

Umm my doctor specifically told me its usually prescribed alongside an antidepressant, but I don't need an antidepressant.. Just buspsar.

But it's perfectly normal to take the two together. Idk who told you you can't, but that's wrong.

 

[Jktm]

I just say it's unwise to take alongside an SSRI/SNRI because I got serotonin toxicity from being prescribed 400mg of tramadol, 30mg of buspirone, and 60mg of duloxetine.

 

[Morphling]

I would sue. What a lovely mix to cause seizures.

 

[opiatekrzy]

I highly doubt your doctor RXed you a klonopin Placebo, correct me if im wrong, but that can only be done in studies with a patients consent that they may receive the actual drug or a placebo. Also given the long half life Klonopin has, and the very long duration, if you continuously keep dosing it, for example (twice a day or 3x a day) you won't really feel it kick in each time you take it, not to mention tolerance and dependency will occur, meaning you become immune to the dose ur taking if taken daily , same dose also daily. I take klonopin every morning (2mg), and I don't feel it kick in, or feel anxiety relief, or any of the benefits, because my body is used to it, and im sure its decreasing my anxiety without me noticing it having to feel buzzed.

Like the above posters mentioned, klonopin is not ideal for panic attacks due to its slow acting properties, if you happen to have a panic attack, by the time the klonopin kicks in, the panic attack more then likely will have passed. Short acting benzos are better for panic attacks (Xanax, Ativan) They literally kick in orally within 5-10mins on an empty stomach, and knock the panic attack right off the map, remember, constantly using short acting benzos will rapidly cause a tolerance increase, and you will need more MGs for panic attack relief, so use sparingly and really as needed

 

[Venrak]

Buspirone functions as a serotonin 5-HT1A receptor partial agonist[5][8] (IA = 0.465).[9] It is this action that is thought to mediate its anxiolytic and antidepressant effects. Additionally, it functions as a presynaptic dopamine agonist D2, D3, dopamine antagonist D4,[5][10] as well as a partial α1 receptor agonist. The ability of buspirone to selectively block presynaptic mesolimbic D2 autoreceptors in lower doses appears to result in increased dopamine synthesis and release.[11][12]

Positive results for the treatment of depression when buspirone was combined with melatonin has been shown. It is suspected that the method of action differs from SSRI medications. Preliminary research suggests that the combination of buspirone and melatonin stimulates the growth of new neurons in the brain, also known as neurogenesis.[13][14][15] Although never commercially produced, Bristol-Myers Squibb applied for a patent on Oct 28, 1993 and received the patent on Jul 11, 1995 for an extended release formulation of buspirone.[16]

source

5-HT1A receptors can be located on the cell body or soma, dendrites, axons, and both presynaptically and postsynaptically in nerve terminals or synapses. Those located on the soma and dendrites are called somatodendritic, and those located presynaptically in the synapse are aptly titled presynaptic. As a group, those receptors that are sensitive to the transmitter that is released by the neuron on which the receptors are located are known as autoreceptors; they typically constitute the key component of an ultra-short negative feedback loop whereby the neuron's release of neurotransmitter inhibits its further release of neurotransmitter. Stimulation of 5-HT1A autoreceptors inhibits the release of serotonin in nerve terminals. For this reason, 5-HT1A receptor agonists tend to exert a biphasic mode of action; they decrease serotonin release and postsynaptic 5-HT1A receptor activity in low doses, and further decrease serotonin release but increase postsynaptic 5-HT1A receptor activity at moderate to high doses by directly stimulating the receptors in replacement of serotonin.

source

This would indicate that higher doses of buspirone will have more risk of causing SS when combined with antidepressant medications, but Jktm, I think the problem was that you were on tramadol, buspirone and duloxetine at the same time. Those three are serotonergic, and it's dangerous.