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If a medicine reduces psilocybin activity dose-dependently...

bees_knees

Bluelighter
Joined
Mar 22, 2013
Messages
166
...does psilocybin reduce the activity of that medicine dose-dependently?

ie. if someone is on an anti-psychotic (antagonist) active at 5-HT2a (serotonin receptors), and they take heaps of mushrooms (agonist), say, 3-5x the usual dose, will it overcome the antagonism or no?

Please don't bring up how bad it is to take mushrooms when apparently ill, I've discussed this elsewhere. Here I am just wondering how the neurology works.
 
depends on the medication and whether or not the anti-psychotic is a competitive or non-competitive antagonist. a competitive antagonist will compete with the shrooms for binding at the 5ht-2a receptor sites, and usually competitive antagonists have very strong affinities (bupre for example) and will block other drugs that bind to that specific site from agonizing the receptors.

a non-competitive antagonist (like ketamine agonizing opiate receptors) wont fight the shrooms and usually does not have strong affinity for specific receptors, but the situation may vary...

i would be able to answer your question more efficiently if you were to name a specific medicine so that i could check out the Ki values and see if the medicine will compete or not compete to affinity
 
Chances are, any anti-psychotic will dull your high to distasteful levels.

BDD -> PD
 
In my case it's currently a moderate dose of Risperidal (risperidone) and a moderate dose of Saphris (asenapine).

Noted on the distasteful high. I suspected something like that.
 
I know you say that you've discussed it else were, but I can't help myself but to tell you how extremely assinine it is to take psychedelic drugs while you are being given 2 anti-psychotic drugs. I asume your doctor is giving them to you for a reason.

How important is it to trip right now? Can't wait untill you're off the medication and in a more stable period?
You only have one mind, once it's broken no one can fix it.
 
How long have you been on that medication? It has a lot to say IME..

I doubt you will get anything usefull out of trying to overrule the effects of the antipsychotics with shrooms.
 
Most antipsyhcotics have a higher affinity for serotonin receptors than psilocin does, so trying to "break the blockade" will generally end in tears unless you stop taking your a/p.
 
I was off medication for like a year before my mother just went and said, he's having an episode, so these authorities come to my house and I panic, and the panic reproduced all the symptoms of psychosis. I was taking mushrooms and I probably presented really weird to mum a few times while tripping.

:(

Long story:

The reason for the anti-psychotics is because apparently free associating with jokes out of sheer boredom, thinking for yourself, and getting really excited in an attempt to feel good about life, is not only stupid, but PSYCHOTIC, ...oh no!

I appealed to the Review Board, who deals with patient disagreements, on two occasions, on both occasions they went with what protected their jobs the most, since they think I had objective episodes - that's what the case file said, when all was doing was talking fast about some shit I wanted life to be (ie. you think everything is potentially imagination? Geez what a delusion, what a formal thought disorder, etc.), or I was bored, and I had panic disorder, and every time I was confronted with authority I panicked, so I'd just walk in there and panic. "Oh look, a thought disorder, he can't express what he's thinking." Apparently every time I came off the medication I had another "episode", which is like, dropping a spoon and getting slightly angry, so they just ruled in the psychiatrist's favor since if they overruled him I could just get off meds, and they'd be responsible for my squeezing of a stress ball really hard when the psychosis returned.

I think of them as bureaucratic bunch of mediocre assholes. They don't actually give a shit about me, what they give a shit about is not losing their jobs.

Do you see / get what I mean?

I was just trying to pursue something. I found some things out. It's horrible. Please, show a little sympathy.
 
I had a DXM trip two nights ago, btw. It was quite amazing. I am fine right now, even better perhaps than recent days.
 
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