Ibuprofen's effect on wound healing

[Cartesia]

Just wondering if anyone has any information on the method of action of ibuprofen causing reduced wound contraction ? I think it is only specifically in high-dosage continual use that this occurs.

(cut stops bleeding with the clotting, but then just remains like a hole in the skin for a couple weeks (the kind of cut that should only take 2-3 days to completely dissappear)

 

[Epsilon Alpha]

Well off the top of my head I recall that inflammation of the surrounding tissue to a wound is required for it to be "pushed closed", but going further than that requires a ton of prostaglandin and clotting factor interactions.

I think mindandmuscle.net has a few threads in the archive discussing this in depth if you'd like to search for it over there.
But several of the NSAIDS have negative effects on collagen synthesis and repair so I hope this points you in the right direction.

http://jhs.sagepub.com/content/26/3/224.short
http://www.ncbi.nlm.nih.gov/pubmed/2150741

 

[Burn it up]

Non esteroideal anti inflamatory drugs such as ibuprofen or aspirin decrese collagen synthesis, thus slowing the wound healing proccess.
In the case of ibuprofen, it upregulates the production of some enzymes which degrade collagen.

Sorry, forgot the link: http://www.ncbi.nlm.nih.gov/pubmed/19847888

 

[Cartesia]

thanks both!