I was falsely diagnosed and forcefully injected with clopixol on the april 15th. Ever since then, My joy,motivation and happiness have been severely reduced and my emotions are severely restricted. Thinking is also hard and it feels dull. Living is hell. I've been suffering this for more than 2 months and I'm looking for a solution. I want to get pescribed apomorphine for it because of it's high affinity level. I'm planning for it to compete with the Clopixol and bind to my dopamine receptors. Is there anything wrong with doing this? Please tell me if it would work or if there's something I'm not getting right.
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I want to undo the effects of a dopamine antagonist with a dopamine agonist. Would it work and is there anything important i should know?
- Thread starter Matthew01
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bigjackaal96
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Diphenhydramine at 75 ~ 250mg should be used since your ACH now higher than D2, It actually used as a anti parkinson med.
How did you now my ach is higher than d2? Did the clopixol cause this? Also you didn't tell me if my solution would work. Would it work? It sounds like it should right? Dopamine agonist stimulate Dopamine receptors. Also the drug you mentioned agonises the H1 CNS receptor, my problem is blocked dopamine receptors
bigjackaal96
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Because of the ratio being out of whack high ACH will choke what remaining dopamine you have. It a anticholinergic It will let your Dopamine levels reach baseline through M4 antagonism acting bit like a DAT blocker(Adderall, Ritalin).
I've have already taken an anticholinergic agent called akineton twice. All it did was help the movement problem but it didn't help the other problems I mentioned earlier. I don't think the problem is dopamine,it has to be dopamine receptors. Do you think they are still blocked? Clopixol blocks dopamine receptors. Also do you think my plan would work? What do you think of it?
bigjackaal96
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You need to get checked to get anything that boosts dopamine directly, Even If It ADHD meds.
Even if it's ADHD meds? Like something like ritalin? Would my blocked dopamine receptors affect that? Also what do you think of my plan? Is it dangerous? I'm planning to use either apomorphine or cabergoline because of it's high affinity level.
emkee_reinvented
Bluelighter
False diagnose, means a dr. prescription and forced injection.
Imo they caused it that hospital, or clinic is responsible.
Aren t they then not logical ones to treat it, the ones that caused it ?
Not by the dr. that did it, i d demand, but by a asking
explicit a college hat did get its grades by learning.
Or get your medical files there, and ask a reference for a 2-nd opinion elsewhere.
I would, one big mistake like that, 100% distrust in the whole facility.
Sorry it happened to you, been there often, wrong dr s/
with Kakalawaka diagnosis. Are there uberhaupt dr s these day s that are not ?
Endurance, you ll need, and hope they can undue it.
Sound as 'it suck s' [wrong diagnose/ lasting side effect s/ fuck-ups]
2 month s letting you suffer, quak s/ no medical doc s imo.
I was on Valproic Acid while conceiving my son, since 2018.
The manual was changed not only woman also man may not get pregnant.
As also male seed carries the risk of raised change you kid get s Autism.
From VPA, my son conceived before they knew this is Autistic.
I don't want to go back to them, they are horrible people. I live in a 3rd world country, the doctors in here aren't even considered doctor abroad, if they go there,they would forced them to be retrained.do you think there's something I can do? What do you think of my plan? Is it safe?
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Dopamine agonists are dodgy. They cause weird ocd symptoms even in people with no history. I would tred with caution
emkee_reinvented
Bluelighter
Can t answer that. I lack pharmacological background nor insight on the matter.
That doesn't sound too bad. I feel like my emotions are severely restricted, like as if I am emotionless. I also feel like like my joy,happiness and motivation have been severely reduced, i can't even enjoy music or have that otherworldly feeling i get when i listen to certain songs,thinking also hard and dull. It has to work, right? Just find a dopamine agonist with a higher affinity level than clopixol so it can overpower it,right? I need my emotions and joy right back now, living is hell. Do you think it would work?
vlzinspace
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nobody would be able to provide a factual answer aside from anecdote. has it progressed at all or does it seem stagnant like you're not healing? how is your sleep quality?
Doesn't it feel like it has progressed at all, feels like I'm the same, it's been going on for more than 2 months. The akineton they gave me twice help with the slow and bad movement problems,not sure if it has fully healed but it's not very noticeable. Also not sure if it was safe i was given akineton a second time. At the early start after receiving the injection, my sleep was very bad, found it hard to sleep and would wake up at night, found it hard to sleep back. I also couldn't sleep in the afternoon. The emotionlessness is very painful and makes it hard to sleep. What's in the clopixol that causes this? My mind still has the same problems I mentioned earlier. A person once recommended me diazepam for sleeping pills but that isn't FDA approved so I didn't take it. I really need to find someway to fix this, fast. Living like this is absolute hell. Do you know anything I can do to help myself?
vlzinspace
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dopamine aside from a feel good is a neurotransmitter so it is used as a chemical messenger in the nervous system and everybody's wiring is different, so the clox is "stopping certain signals"
personally i would say to address sleep first and foremost, your brain cleans itself out during rem (deep sleep not crap quality), i've had a few persistent effects from wellbutrin/seroquel in my past and even HPPD from LSD, all were steady and persistent but seemed to resolve when i got real good sleep, which i had to quit weed etc to establish. i had HPPD for bout a month and after i quit weed etc my mind healed on day 5
i wouldn't take diazepam, or really any sleep meds, not even weed, those will help you fall asleep sure but they diminish sleep quality, atleast try not to
chatgpt (its info, anyways), says that under some circumstances a doc will prescribe an agonist alongside clox for the very reason of symptom reduction, but that it must be monitored. sorry you are going through it. hang in there
I going to try by getting pescribed dopamine agonists. Does anyone else know if this plan would work? Please its urgent
I don’t think people typically enjoy dopamine agonists. They tend to mainly be prescribed for things like Parkinson’s, restless leg syndrome, or other niche conditions. None of them are scheduled, which indicates that people don’t enjoy them enough to abuse them commonly.
The dopamine receptors (D1 through D5) can be divided into two groups. Activating D1 like receptors in the “go” pathway (aka direct pathway) (D1 and D5) stimulates the production of cyclic AMP (a second messenger). The “no go” pathway (aka indirect pathway) consists of the D2 like receptors (D2s, D2L, D3, and D4). These inhibit the production of cyclic AMP.
These two pathways function together (as all dopamine receptors respond to dopamine), and dopamine agonists tend to be a bit selective (often for the D2 class). Apomorphine has a higher affinity for the D2 family over the D1 family. These drugs aren’t known to be euphoric based on the reports I have seen, but can cause some pretty profound compulsive/addictive behaviors such as addictions to gambling, sex, and shopping but also OCD like symptoms.
Apomorphine has a pretty big problem in that it is considered an emetic. We have dopamine receptors (among others) in this part of our brain called the chemoreceptor trigger zone (ctz). This is a little bit of brain that can sample blood away from the blood brain barrier and it acts as a probe to check if we are being poisoned by something. If it thinks that (via receptor activation ) we will vomit. This is why anti nausea medications often block dopamine (also other receptors).
Cabergoline is also something to avoid as it causes fibrosis of your heart valves over time (cardiac fibrosis) due to agonism of serotonin 2B receptors.
Finally, you have been getting over an injection of a long lasting antipsychotic. These things take quite a bit of time to reverse, and it’s only been since April. I know you are likely feeling bad, but this isn’t a way forward— you need to let time do its work, and think in a timescale of how you feel after every 6 month chunk rather than every month.
I know this might not be the answer you want to hear, but your plan to counteract the lingering antipsychotic malaise with dopamine agonists seems very risky for the low likelihood that it would succeed.
Indirect dopamine agonists (ie releasers or reuptake inhibitors) would certainly be a better option with regards to actually doing what you want, but those will be quite a bit more addictive, and you will likely still be disappointed in how little they work.
The dopamine receptors (D1 through D5) can be divided into two groups. Activating D1 like receptors in the “go” pathway (aka direct pathway) (D1 and D5) stimulates the production of cyclic AMP (a second messenger). The “no go” pathway (aka indirect pathway) consists of the D2 like receptors (D2s, D2L, D3, and D4). These inhibit the production of cyclic AMP.
These two pathways function together (as all dopamine receptors respond to dopamine), and dopamine agonists tend to be a bit selective (often for the D2 class). Apomorphine has a higher affinity for the D2 family over the D1 family. These drugs aren’t known to be euphoric based on the reports I have seen, but can cause some pretty profound compulsive/addictive behaviors such as addictions to gambling, sex, and shopping but also OCD like symptoms.
Apomorphine has a pretty big problem in that it is considered an emetic. We have dopamine receptors (among others) in this part of our brain called the chemoreceptor trigger zone (ctz). This is a little bit of brain that can sample blood away from the blood brain barrier and it acts as a probe to check if we are being poisoned by something. If it thinks that (via receptor activation ) we will vomit. This is why anti nausea medications often block dopamine (also other receptors).
Cabergoline is also something to avoid as it causes fibrosis of your heart valves over time (cardiac fibrosis) due to agonism of serotonin 2B receptors.
Finally, you have been getting over an injection of a long lasting antipsychotic. These things take quite a bit of time to reverse, and it’s only been since April. I know you are likely feeling bad, but this isn’t a way forward— you need to let time do its work, and think in a timescale of how you feel after every 6 month chunk rather than every month.
I know this might not be the answer you want to hear, but your plan to counteract the lingering antipsychotic malaise with dopamine agonists seems very risky for the low likelihood that it would succeed.
Indirect dopamine agonists (ie releasers or reuptake inhibitors) would certainly be a better option with regards to actually doing what you want, but those will be quite a bit more addictive, and you will likely still be disappointed in how little they work.