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Misc I think I may very well be immune to opoids/MDMA!

It's not an "immunity" because the immune system is not involved, nor does it have anything to do with your brain. It's the way that your body metabolizes opiates through the CYP450 system, which is determined genetically.

Opiates are metabolized through a variation in CYP2D6. If you have ultra-fast metabolizer status, it means you have multiple copies of this gene which means more of the related liver enzyme is produced, and the drug gets processed so fast that its pharmacology doesn't get to impact your body. If it's your entire CYP2D6 group and not just one sub-set, then you also might not experience effects from amphetamines, mushrooms, or LSD either, or you would need a much higher dose to feel anything.

I myself have multiple copies of CYP1A2, which I discovered through genetic testing. This group covers caffeine, which does nothing to me. I can drink 6 cups of coffee and feel nothing. Unfortunately, dental freezing is processed under the same enzyme, so when I get dental work done there's no way to numb my mouth. :(
 
If you've got the good denver tar or gunpowder, I don't know what to tell you. We get the good shit here! The pills and 'molly' are a lot more sketchy, tho. Dunno what to tell you.
 
i have a feeling if you banged some good real powder diesel you'd be off ya muthafuckin ass yo
 
Most people don't get euphoric effects the first time they use an opiate just sedation and pain-relief it's why the medical world actually endorses responsible use. I only started noticing the positive effects about the 3 time i took codeine, of course I eventually completely "discovered" the feeling.


Also if you're not on an SSRu you just got bunk-mdma or too low a dose.

sorry you're not that special just young if you want to get there you will...
 
Anyways, I would honestly just give up. The fact that you feel its important to get a real opiate high seems indicative of possible problems to come should you succeed. I don't say that to be rude or offensive, it's just been my experience that the people who want to achieve this type of high often end up chasing it when they do.

This is exactly what I thought when I first read the OP.
 
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