Not long ago I took enough metocin to trip on, however, the results were blunted. I asked ai about my medication combo, results said any of the three medications listed when taken separately would not inhibit hallucinogenic effects of metocin. However, when taken together metocin works almost entirely through 5-ht2a receptor agonism, together creates a high baseline serotonin which can cause
down regulation of 5-ht2a receptors, reduce psychedelic sensitivity, muted visuals and reduce "headspace"
This is the same reason seri's often blunt psychedelics. even though my meds are not seri's, the net effect overlaps.
Vyvanse competes with psychedelic signal by producing a strong dopamine drive, high cortical stimulation, increased task-oriented focus, and reduces introspective drift. Vyvanse pushes the brain in the opposite direction by not blocking psychedelics, it overrides them
sam-e raises serotonin, reduces 5-ht2a sensitivity
Doxepin sedation, anticholinergic dulling, blunts sensory/emotional effects
Vyvanse high stimulation overrides psychedelic cognitive state
possible solution non-stimulants (least interference).
strattera-norepinephrine-focused, no dopamine release
intuniv-calming, reduces hyperarousal
clonidine-similar to guanfacine, more sedating
'Wellbutrin-dopamine/norepinephrine modulator, but not a stimulant
reasons-they don't compete with psychedelic cognition states
they don't amplify the stimulant-sedative tug-of-war created by Vyvanse + Doxepin
they don't raise serotonin, less likely to blunt 5-ht2a sensitivity
methylphenidate stimulants-middle ground
ritalin, concerta, foclin
they increase dopamine/norepinphrine by blocking reuptake, not by forcing release.
they produce less emotional intensity and less cognitive override than amphetamine
I see my provider Friday to discuss Vyvanse options
down regulation of 5-ht2a receptors, reduce psychedelic sensitivity, muted visuals and reduce "headspace"
This is the same reason seri's often blunt psychedelics. even though my meds are not seri's, the net effect overlaps.
Vyvanse competes with psychedelic signal by producing a strong dopamine drive, high cortical stimulation, increased task-oriented focus, and reduces introspective drift. Vyvanse pushes the brain in the opposite direction by not blocking psychedelics, it overrides them
sam-e raises serotonin, reduces 5-ht2a sensitivity
Doxepin sedation, anticholinergic dulling, blunts sensory/emotional effects
Vyvanse high stimulation overrides psychedelic cognitive state
possible solution non-stimulants (least interference).
strattera-norepinephrine-focused, no dopamine release
intuniv-calming, reduces hyperarousal
clonidine-similar to guanfacine, more sedating
'Wellbutrin-dopamine/norepinephrine modulator, but not a stimulant
reasons-they don't compete with psychedelic cognition states
they don't amplify the stimulant-sedative tug-of-war created by Vyvanse + Doxepin
they don't raise serotonin, less likely to blunt 5-ht2a sensitivity
methylphenidate stimulants-middle ground
ritalin, concerta, foclin
they increase dopamine/norepinphrine by blocking reuptake, not by forcing release.
they produce less emotional intensity and less cognitive override than amphetamine
I see my provider Friday to discuss Vyvanse options
