and....haha there’s this one
C12C(F)(F)C(F)(F)OC1=C(CCN)C=C1OC(F)(F)C(F)(F)C1=2
www.swisstargetprediction.ch
molview.org
then there’s this..........
C12=C3C(OC(C3(F)F)(F)F)=CC(CC(C)N([H])CCC(N(CC)CC)=O)=C1OC(F)(F)C2(F)F
www.swisstargetprediction.ch
molview.org
this one pulled up three things that worry me which worry me about all experimental/investigational psychedelics; thrombosis . i don’t really know what i’m doing (i like the supposed einstein quote on that really , because some people who are very educated in sciences; and given lots of access , can be snobs)
but i like to keep thinking and rolling with it and re approaching; not fully disgarding slight possibilities but wising up to knowledge from people more knowledgeable than myself. there’s a lot to learn; some things i think about are the affinity to the serotonin 2a compared to the complex it makes with the metabotropic glutamate r2 receptor. (i was wondering if a specific 2C receptor antagonist that didn’t effect 2A could drive some psychedelic to be experienced different because it couldn’t displace the antagonist at 2C and instead went to 2A more than normal; or to the 5HT2A*MGluR2 complex more than it would. i guess they probably thought and looked or didn’t because they thought it wasn’t important; or can’t because there isn’t a selective and potent enough 2C antagonist . idk. but there seems to be safe psychedelics and unsafe ones and the effects are all different in actual experience; so i’m just wondering where the gold is and what makes a psychedelic really good to take; compared to merely potent and possibly deadly
i didn’t run the alpha methyl because of how 2c-b fly turned to bromo dragonfly was seemingly giving much more thrombosis. i’m not sure if that is at equivalent doses or because of potency issues in overdose, but even DOI seems to have thrombosis. heroic levels of 2C-I don’t seem to be reported much; i’m just incomplete on my knowledge here. what i’ve gathered is that highly potent stuff seems to be real directed at 5HT2A but the affinity for the 5HT2A * MGluR2 cogener is not reported. usually it’s a 2C/2A comparison. the 2B is similar but not identical to the 2A but i don’t know if it is also a thing that varies depending.
but the potent stuff doesn’t seem to be better; if anything worse.
i was just wondering if the unique effect of flourine gives it “color” but also makes it famn near impervious to attack. also though it seems to be one of the most electron withdrawing things i could model on “mo-cubed” which while likely very inaccurate, has a quantum computation function and i will post the one where it has a 2-SMe too because that was rad to look at (well, if it shows up ok on the target predictor maybe)
but i was thinking maybe an NDEPA would make it less potent ironically, because i think they are less potent than NBOMe compounds “normally”, from what i read from hans meyer. so i’m wondering if the crazy flourine molecule had some problems like the bromo dragonfly (but it isn’t a modified aromatic so it’s a plain benzene , and hopefully it’s different..) then being a regular PEA seemed the first best test; and then skipping straight over the alpha methyl; to the alpha methyl n diethyl propan amide. maybe
but the target predictor gives no targets as percentages: 100 though: and in an order that j am unsure of regarding priority;
my main concerns and hopes that it doesn’t touch upon at all are
•Coagulation Factor VII
www.swisstargetprediction.ch
•Thrombin and Coagulation Factor X
www.swisstargetprediction.ch
•Thrombin
www.swisstargetprediction.ch
•Corticotropin releasing factor receptor 1
www.swisstargetprediction.ch
i see the first is 5HT2A (no actual percent likelyness given)
but also, very far down is the 5HT2B, so that’s what i mean by this not being maybe very accurate; but i’ve learned to take what i can get to educate myself; from mol view to mo-cubed to iSpartan to now this;
it’s cool to see i have a lot more to learn and reach for in biochemical receptors, biopharmacology etc, when at least the data seems accessible
ok well idk