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I Like to Draw Pictures of Random Molecules

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NvtXxDL.jpg


I was bored when I made this one.
vWtCdLy.jpg
 
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Dresden said:
aced126,

I like your methyl carboxylate amfonelic acid idea.
Click to expand...

Nice idea. The antibiotic part looks like Fluro-Quinolones. They can inhibit DNA synthesis indirectly by inhibiting DNA gyrase which is an topoisomerase that is uniquely for bacteria.

The Fluro group that attached to the Quinolones enhances the antibiotic effect significantly. I guess that amfonelic acid has not strong antibiotic effect like the F-Quinolones. I wonder in what dose amfonelic acid gives antibiotic effect?
 
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FA notoriously difficult to synthesize and terribly insoluble even the salt will barely dissolve in water. only in very unfriendly solvent like DMSO or DMF. Can you make it somehow more soluble and synthetically accessible eg by reacting...euhhhhhhh! wait nothing!

Any reasons tho why Amfonelic acid didn't really become popular in RC market? some years ago(circa 2010ish) the analog where the benxyl is replaced by a phenoxy was available from some vendors. Easier to prepare and cheaper I guess and It does pretty much the same thing as AFA. Any thoughts on why it never took off??


amfo1_zpsbqhjo0mo.png
 
The reports I've read on Amfonelic acid have all been pretty positive. Even fastandbulbous thought it was very nice. Amfonelic acid probably didn't take off because of the fact that it's a hard synth. The phenoxy derivative, I'm not sure why it isn't popular. Maybe it just isn't as good as Amfonelic acid. Can you link any anecdotal reports on the phenoxy derivatives?
 
Interesting, it might well work. Your compound has a few possible ways it could exert its action. Any affinity at the GHB receptor will result in excited neurons. It might agonise GABAR (stronger or weaker) which will result in inhibitory responses. It might even (especially if the alcohol is replaced in the amine; this compound would have definitely been made and tested while making Lyrica) block a2-delta voltage gated calcium channels, resulting in normally inhibitory responses as well.
 
aced126 said:
(especially if the alcohol is replaced in the amine...
Click to expand...

Do you mean replaced with an amino group? In that case that'd make it phenibut, which does work on the VDCCs. Actually I'm intrigued as to what kind of pharmacology this (roi's) compound would display; GHB with a long half-life?
 
roi said:
4-hydroxy-3-phenylbutanoate.png


PheniGHB. Could that even work?
Click to expand...

if that phenyl ring was a cyclohexyl ring, that would be gabapentin with a change analogous to the change from GABA -> GHB (amino -> hydroxy)

edit -- almost... i overlooked a carbon. still probably an active compound, just who knows what that activity would be.
 
Yeah, I meant that Belligerent. I'm sure lots of SAR work has been done on VDCC blockers, seeing as there are many complex gabapentinoid derivatives on Wikipedia itself.
 
Few more:

(3S)-3-(hydroxymethyl)-5-methylhexanoic%20acid.png


(3S)-3-(hydroxymethyl)hexanoic%20acid.png


2-%5B(3S)-oxan-3-yl%5Dacetic%20acid.png


2-%5B1-(hydroxymethyl)cyclohexyl%5Dacetic%20acid.png


Problem is that none of these are likely to be somewhat potent (dose < 100mg).
 
Can't be more drug-like than that. But beware of being too good for CNS drugs. i.e. can bind at multiple receptors besides 2a eg D4 will probably like it (but then again you get a horny trip! as D4 agonists make males rats incredibly horny!). But pretty cool! reminds me vaguely of this dewormer structurally

220px-Praziquantel.svg.png
 
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