I Like to Draw Pictures of Random Molecules

[crmt28]

And when Sasha Shulgin accidentally made this next one (and took some), he wrote--summarized--that it, "Was an extremely weird trip that bore no resemblance to any currently known class of drugs that he had tried":

2-methylamino-4-(3,4-methylenedioxyphenyl)butane.

That's an interesting one! That one would be a MDMA analogue of phenpropylamine! I wonder if the bad effects could come from the alpha-methylation, or the methylenedioxy, and what receptors it hits.

Also, never heard about this one from Shulgin! Was that quote on the full version of PiHKAL?

Here's the 2C-B analogue from that compound:

 

[Dresden]

It's somewhere in PiHKAL. Something about piperonyl this or that being sold according to some mistaken identity nomenclature and thusly producing said compound. Probably in the discussion of one of the MD-drugs somewhere in the second (chemical) half of the book. I personally haven't read the thing in many years and no longer have a copy, either.

* * *

In unrelated news, here's one that's likely not scheduled in China and which I wouldn't mind trying either:

Or even:

Though I understand that this one gives people psychotic, suicidal tendencies:

Perhaps the N-ethyl homologue of ibid. would be more forgiving?:

And, with this, I'll end with a likely winner:

I've actually always referred to this last molecule as "GREEN" for no known reason.

P.S.

However, from whisperings heard at the Hive long ago, this PMA derivative is supposed to be a first rate psychedelic.:

Therefore, I think I'll name it HEARSAY.

 

[Nagelfar]

Cocaine's duration is what makes it a useless and too addicting drug ime

Ability to repeat subjective *rush* affection from a quick onset route of administration: e.g. intravenous or smoked. I think that's something the cocaine-over-amph taste aims for.

 

[Dresden]

Well, if that feels like cocaine but lasts way longer, then sign me up.
However, I feel like this next one would be better:

DOC illegal now? No problem!:

 

[SKL]

Somewhat but not quite in this genre is β-CFT ( WIN 35,428 ) ...

I thought of it when long acting cocaine analogs were mentioned. It's a pretty cool drug which I tasted and wrote a trip report/commentary on a ways back.

 

[flying-potato]

4-CMMC ?

 

[Dresden]

Sick of subpar fluoro and methyl phenmetrazines? Check out this series of O-->CH2 phenmetrazines.:

 

[Nagelfar]

In unrelated news, here's one that's likely not scheduled in China and which I wouldn't mind trying either:

....

Or even:

The para-cis-propenyl-amphetamine (lower right), seeing what the p-cis-propenyl troparil/phenyl-ecgonine does (renders it so as to not bind to NET, but still to DAT & SERT. cf compound (RTI-)"11w").

Also since the cycloalkane on phenmetrazine seems to make it a subjectively more euphorgenic substance than n-methyl-amphetamine, but the benzylpiperidines have poor stimulation, how about just tweaking (no pun intended) the ring to a shorter, more amphetaminesque type substance (upper right). Less metabolically labile perhaps as a benefit? The double bond in the middle (lower left), simply because the 3-beta-styrene cocaine analog had such better affinity. The remaining one (upper left) just incase the QSAR requires that instead of the para position.

Somewhat but not quite in this genre is β-CFT ( WIN 35,428 ) ...

I thought of it when long acting cocaine analogs were mentioned. It's a pretty cool drug which I tasted and wrote a trip report/commentary on a ways back.

Thank you for that, missed it the first time through. Nice to see some colloquial input on these kind of compounds.

 

[white55]

1p-dmt... would the same trick that works for lysergamides work for tryptamines?

 

[Solipsis]

I actually thought of that right when 1P-LSD became available but I realized a problem: 1P-LSD itself cannot be active according to Nichols, it must be depropionylated. If 1P-DMT is administered, will the propionyl group be cleaved before MAO noms up the DMT? Perhaps but it does seem like a possible kinetic contraindication.

More substituted or N-bulkier tryptamines should work great though, they don't have that window of opportunity involved for DMT...

Then again IM DMT worked for nearly 45 minutes, 20 of which very psychedelic involving entities.. about double the duration of vaped for me. Maybe it could work.

 

[roi]

I actually thought of that right when 1P-LSD became available but I realized a problem: 1P-LSD itself cannot be active according to Nichols, it must be depropionylated. If 1P-DMT is administered, will the propionyl group be cleaved before MAO noms up the DMT? Perhaps but it does seem like a possible kinetic contraindication.

More substituted or N-bulkier tryptamines should work great though, they don't have that window of opportunity involved for DMT...

Then again IM DMT worked for nearly 45 minutes, 20 of which very psychedelic involving entities.. about double the duration of vaped for me. Maybe it could work.

http://onlinelibrary.wiley.com/doi/10.1002/dta.1884/abstract

While 1P-LSD shows only 38% the potency of LSD in mice, LSD is detected via LC-MS when 1P-LSD is incubated in human serum. So it seems to act as a prodrug for LSD in humans after all?

 

[white55]

I actually thought of that right when 1P-LSD became available but I realized a problem: 1P-LSD itself cannot be active according to Nichols, it must be depropionylated. If 1P-DMT is administered, will the propionyl group be cleaved before MAO noms up the DMT? Perhaps but it does seem like a possible kinetic contraindication.

More substituted or N-bulkier tryptamines should work great though, they don't have that window of opportunity involved for DMT...

Then again IM DMT worked for nearly 45 minutes, 20 of which very psychedelic involving entities.. about double the duration of vaped for me. Maybe it could work.

Makee it 1p-4-ho-dmt or 1p-4-ho-met then Anyway well known vendor thought it as a good idea and said they'll look into it.

 

[roi]

Inspired by metabolites of tert-butyl-cathinones:

 

[white55]

desmethyltriazolam - longer lasting triazolam (same way as metizolam is a longer lasting etizolam)

ethoxetamine

1p-eth-lad

3-methylbutyrfent

 

[roi]

3-methylbutyrfent already exists. Supposed to be identical to butytrfentanyl, just 10x more potent.

http://www.bluelight.org/vb/threads/759536-Novel-opioid-3-Methylbutyrfentanyl

 

[roi]

 

[Solipsis]

whats that modeled on?

 

[roi]

https://en.wikipedia.org/wiki/Azaprocin

With these modifications it should be ~50x morphine.

 

[Dresden]

Might be dangerous. Nonetheless, a brilliant concept--don't get me wrong.

 

[roi]

Should be a MDMA prodrug.