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I Like to Draw Pictures of Random Molecules

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4-chloro-DMT looks interesting. :)

I actually am 3 semesters into a bachelor's degree in chemistry. didn't learn any pharmacology yet :)
 
You have to take psychopharmacology as an elective. I took 3: One in the Chemistry department, one in the Psychology department, and one in the Psychobiology department.

You should definitely start reading PiHKAL, though. (Pick up a generics Physician's Desk Reference while you're at it). Here are two of my favorite quotes from it:

2-amino-1-(3,4,5-trimethylphenyl)-propane.png


^--"Very hard on cats."

and

2-amino-1-(4-methylthio-1,3-benzodioxole-5-yl)-propane.png


^--"And visions of sugarplums danced in their heads."
 
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While I'm at it...

3-dimethylaminoethyl-2-(4-methylphenyl)-indole.png


^--See also Ambien's (zolpidem's) structure, a sedative-hypnotic.

5-ethoxy-3-dimethylaminoethyl-indole.png


The 5-EtO is supposed to take some of the unwanted oomph out of 5-MeO-DMT and is not as "illegal."

6-methoxy-3-dimethylaminoethyl-indole.png


Could be a winner! Is probably far out.

7-hydroxy-3-dimethylaminoethyl-indole.png


I couldn't decide whether to give this one a 7-hydroxy or 7-methoxy or 7-chloro.

6,7-methylenedioxy-3-dimethylaminoethyl-indole.png


Not the easiest thing to whip up probably.

6,7-methylenedioxy-3-(1-aminoethyl)-indole.png


Again, ditto: Not the easiest synth, I would imagine.

3-(1-aminoethyl)-indole.png


(These last two are most definitely long shots. What they do have going for them, though, is a quasi-alpha-methylethylphenyl backbone pharmacophore.)

2-(3,4-methylenedioxyphenyl)-3-dimethylaminoethyl-indole.png


Bet it would feel nice!

2-(3,4,5-trimethoxyphenyl)-3-dimethylaminoethyl-indole.png


Funky!

4-hydroxy-2-(2-methoxy-4,5-methylenedioxyphenyl)-3-dimethylaminoethyl-indole.png


The extra 2-methoxy activates the benzodioxole ring system even more.

5-methoxy-2-(3,4,5-trimethoxyphenyl)-3-dimethylaminoethyl-indole.png


"Quattro Methoxy"

1-pentyl-5-methoxy-3-(diethylaminocarbonyl)-indole.png


The last one is supposed to be a synthetic cannabinoid. Too structurally facile to be true?
 
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1-pentyl-3-dimethylaminoethyl-indole.png


Some kind of hybrid.

1-pentyl-3-(dimethylaminoethan-1-one-1-yl)-indole.png


Another hybrid, this one inspired by DMT and the JWH's.

1-(3-indolyl)-2-dimethylamino-1,2-dioxo-ethane.png


Wonder if anyone has ever thought of trying this DMT intermediate which might be active in its own right?

bis(2'-hydroxyethyl)-lysergamide.png


More closely resembles the HO-CH2CH2NH-(C=O)-R of endogenous anandamide, of whose receptors LSD-025 is almost certainly an agonist. Won't last as long as LSD, if it's even active. Should cross the blood brain barrier well enough, though not as well as LSD, which may necessitate a higher dose.

1-pentyl-diethyl-lysergamide.png


I would try this homologue of LSD before 1-propionyl-LSD any day, as amido nitrogens are generally of a reduced potency when compared to amino ones.

pentan-1-ol.png


n-amyl alcohol, supposed to be shorter lasting and less hangover prone than ethyl alcohol (the kind they sell at the liquor store).
 
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N-(1-(2-phenylethyl)-3-carbomethoxy-piperidin-4-yl)-N-phenyl-N-propionyl-amine.png


Like 3-methylfentanyl but shorter lasting and tastier? (Esters smell delicious.)

2-methylamino-1-(3-methylphenyl)-propane.png


Less damaging than the 4-methyl-amphetamines. Still not good for you.

2-methylamino-1-(3,4-di-carbomethoxy-phenyl)-propane.png


Because we can!
 
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4-carbomethoxy-3-(2-phenyl-ethan-2-onyl)-tropane.png


Improved longevity (on par with methylphenidate) as compared with cocaine.

2,4-di-carbomethoxy-3-(2-phenyl-ethan-2-onyl)-tropane.png


Trippy!

4-carbomethoxy-3-benzyloxy-tropane.png


This one looks promising.
 
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2-amino-1-(4-isopropylphenyl)-propane.png


p-cymene based amphetamine

1-(2-aminoethyl)-3,5-di-isopropyl-4-hydroxybenzene.png


propofol based PEA [CAUTION!]

1-(4-isopropyl-3-hydroxyphenyl)-2-aminopropane.png


thymol based amphetamine

1-(2-hydroxy-4-pentylphenyl)-2-aminopropane.png


A possibly sophomoric attempt to hybridize the amphetamine world with the cannabinoid one.

2-methylamino-1-(2-methoxy-4,5-methylenedioxyphenyl)-propan-1-one.png


O-methyl-sesamol methcathinone, should be about 4x as potent as methylone.

2-amino-1-(3,6-dimethyl-4,5,6,7-tetrahydro-1-benzofuran-5-yl)-propane.png


a menthone (a chemical constituent of the essential oil of peppermint and pennyroyal) based amphetamine [EDIT: I just read up some more on menthone and found out it can be fatal if ingested, making this creation a no-go for human consumption]

1-(5-methoxy-benzofuran-6-yl)-2-aminopropane.png


More than 6-APB bang for the buck!

1-(3-oxoindene-6-yl)-2-methylaminopropane.png


Why not?
 
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Dresden said:
Memorize as many structures as possible, try as many as you can, read trip reports on the rest, and try to find patterns. It's an intuitive process. Also, read PiHKAL by Alexander and Ann Shulgin cover to cover.
Click to expand...

Especially the most important part, the introduction. Sadly the severity of legal consequences is worse now than then. Both PiHKAL, TiHKAL, and The Shulgin Index are excellent reads. When reading PiHKAL or TiHKAL read twice the first few pages.

Alexander Shulgin in PiHKAL said:
CAUTIONARY NOTE: READ BEFORE PROCEEDING

At the present time, restrictive laws are in force in the United States and it is very difficult for researchers to abide by the regulations which govern efforts to obtain legal approval to do work with these compounds in human beings.... No one who is lacking legal authorization should attempt the synthesis of any of the compounds described in these files, with the intent to give them to man. To do so is to risk legal action which might lead to the tragic ruination of a life. It should also be noted that any person anywhere who experiments on himself, or on another human being, with any of the drugs described herin, without being familiar with that drug's action and aware of the physical and/or mental disturbance or harm it might cause, is acting irresponsibly and immorally, whether or not he is doing so within the bounds of the law. -- Alexander T. Shulgin
Click to expand...
 
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regarding the deuterium mescaline... how would deuterium on the methoxy change activity? the should be the same size as normal hydrogen and have the same electron configuration. or is mass itself relevant as well?
 
Dresden said:
2-methylamino-1-(2-methoxy-4,5-methylenedioxyphenyl)-propan-1-one.png


O-methyl-sesamol methcathinone, should be about 4x as potent as methyone
Click to expand...

This is what I hate about this thread, people just dump a shitload of drawings into it and put zero thought into them, and often what thought is put in is completely nonsensical half the time. 4x the strength of methylone? Based on what? 6-methoxy-MDMA / N-methyl-MMDA-2 was significantly less potent than MMDA-2, and being inactive at 70mg (highest dose Shulgin tested) means, if it's active at all, it's less potent than MDMA which is definitely an active dose of MDMA.

Instead of all these drawing dumps why doesn't everyone take a couple ideas and really look into them some? Sure, some ideas don't need a whole lot of looking into. Isopropyl-JWH-695 doesn't need a whole lot of explanation, but if you think it'll be more potent say why. If your goal in posting a compound is to generate thought and conversation about it put some in to start with? If you're not posting them to develop interest and discussion in the compound, why are you posting? Sometimes it seems like people are trying to draw every conceivable variation on the phenethylamine skeleton just for the sake of having them all drawn out somewhere. If that's the goal someone could probably write a program that could go through a big list of substitutions and draw out every one of them on every possible position and every possible combination in every position.

TL;DR- there's too many pictures and not enough discussion of the compounds suggested. If someone has a good idea it could be pursued by some capable members here, but there is a lot of chaff to go through for a couple bits of wheat.
 
I could go into it more, yes, but I don't like sharing my logic with people who don't know how to invent but rather simply criticize. :)

For example,

2-amino-1-(1-oxo-cyclohex-2-ene-4-yl)-propane.png


Testosterone inspired amphetamine.

^--How much more information do you really need? Are you dense? (j/k, I know you're not dense!)
 
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Ok, point taken. So I got a little carried away. Allow me to cut through the chaff for you. These two are potentially brilliant. The first one is a cannabinoid and the second a cocaine analogue:

1-pentyl-3-(N,N-diethylaminocarbonyl)-5-methoxyindole.png


Just trust me. And...

3-benzyloxy-4-carbomethoxytropane.png


The ether bond is much more metabolically stable than an ester, making the cocaine analogue last about as long as MPH.

3-benzyloxy-4-methoxymethyltropane.png


A little bit more of a longshot, but the R-CH2OCH3 works for sufentanyl; obviously, to me anyway, this second cocaine analogue has the potential to work for a very long time indeed. And having lost the oxo off the benzyl, it will be a lot smoother and more focused than original cocaine; this is based on the analogy that methamphetamine (Ph-CH2-R') is focused and smooth, while methcathinone (Ph-(C=O)-R') is not [R' = 1-(methylamino)ethane].
 
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I like the cannabinoid, it'd be interesting if it's active. I saw one recently with a simple pyrrolidine on the N, but it's not very potent it seems.

The idea that removing that will make for a smoother ride is completely erroneous, the group is in a completely different place, serves a different function, and cocaine analogues don't bind in the same mode as phenethylamines.
 
Bagseed said:
regarding the deuterium mescaline... how would deuterium on the methoxy change activity? the should be the same size as normal hydrogen and have the same electron configuration. or is mass itself relevant as well?
Click to expand...

It's not really a new idea, and here's what we know.. I have no idea why roi thinks it will have a very long duration.
 
Ah, I see. But Shulgin didn't find any prolonged duration with either 4-D or beta-D. And I think I trust Shulgin more than wikipedia :)

From PIHKAL:
"The effects of 4-D and beta-D are similar to one-another, both as to dosage and effect. And with both, there is a close parallel to those reported from mescaline. It is reasonable to assume that the human body handles these materials in the same manner, although no metabolic studies have ever been published. "

From the trip reports in there, It sounds like they were almost indistinguishable from mescaline.
 
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