• N&PD Moderators: Skorpio | someguyontheinternet

I Like to Draw Pictures of Random Molecules

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sulfate esters are also generally considered to be incredibly reactive... dimethyl sulfate is a real nasty carcinogen.

a carbonate ester or methylene/ethylene linker (c.f. fenetylline) is the way this is traditionally done, I think.
 
sulfate esters are also generally considered to be incredibly reactive... dimethyl sulfate is a real nasty carcinogen.

a carbonate ester or methylene/ethylene linker (c.f. fenetylline) is the way this is traditionally done, I think.

I thought the reason that the dialkylsulfates are particularly unpleasant is because they are alkylating agents. I considered a carbonate diester, but I chose a sulfate diester because I thought that in this case it would liberate the 2 parent compounds more readily than a carbonate diester and I could not see a mechanism for toxicity, since in this case it is not an ester of simple alkyl group and as such would not act as an alkylating agent. Was this not the correct line of thinking? I would appreciate the input!
 
saw this linked on a different forum (that i can't name) claimed that it will be the future should cathinone bans get even worse. is there any actualy scientific reasoning behind this, or was the person just making stuff up? seems like a pretty radical change from the parent compounds, idk how much activity it would retain:

dl1170.png
 
My guess would be someone borked up drawing para-fluoro methcathinone. In any case, I'll not be imbibing.
 
I can't lie about the fact that I made an account on BL just to post on this thread. Anyway, I wanted your opinion on a molecule that can potentially open the doors to a wide range of pharmaceutical analogues that act as pro-drugs for specific compounds. In common nomenclature (or Shulgin nomenclature, as I like to call it) the compound is called L-4-Bromo-alpha-carboxyl-2,5-dimethoxyphenethylamine (also known as alpha-Carboxyl-2C-B). It is the amino acid analogue of 2C-B, and in my opinion this property allows it to be a pro-drug for 2C-B after it is ingested orally. There is a possibility that this molecule acts as a substrate to the enzyme known as aromatic L-amino acid decarboxylase (AADC), undergoing a reaction that ultimately removes the carboxyl group from the molecule thereby producing 2C-B. In addition, this molecule is most certainly not a substrate for another enzyme called biopterin-dependent aromatic amino acid hydroxylase (AAAH) because of the bromo functional group present on the 4-carbon position. Therefore, if this molecule acts as a substrate for AADC yet it does NOT act as a competitive inhibitor, we have ourselves a novel pro-drug that can have its own analogues! I wish I could post an attachment of a photo, but for some reason I cannot do so. I hope I presented this in a very clear and articulate manner.
 
Well, they are not exactly analogous, but the first image represents DL-4-Bromo-alpha-carboxyl-2,5-dimethoxyphenethylamine, and the second image represents DL-alpha-carboxyl-tryptamine (DL-tryptophan). For them to be substrates of AADC, they must be levorotatory. Honestly, if I was a geneticist, I would create a gene that codes for aromatic D-amino acid decarboxylase. Oh, and right before I posted I learned that N-methylated amino acids are demethylated by N-methyl-L-amino acid oxidase, so I had to scrap the idea of making a pro-drug for DMT and Bufotenin.
 
C8g63.png

Yeah, I'm not equipped or inclined to do anything involving polarised light nowm so there's the two absolute entantiomers, choose whichever you want. Oh, and should you ever muster a thanks, you're welcome.
 
LOL I hope I didn't get under your skin. Trust me, I am very grateful for your help! I was tearing my hair out trying to attach an image to my post, and when I saw your post I was glad someone took the time to create some structural diagrams for me, albeit with some weird-looking double bonds in the phenyl ring haha. I presume the levorotatory stereoisomer is the one on the bottom? If so, that's the only one that would be useful as a pro-drug.
 
You didn't get under my skin, I just thought that a "thanks" was in order! They're aromatic bonds, rather than double bonds, but they do look weird, they can be changed. I prefer the circular notation, but cba right now.
IDK which one rotates light which way. Based on amphetamine stereochemistry, this should be the levo isomer
mtuJH.png
 
Thanks a lot for the systematic name too! If this molecule can follow in the same footsteps as L-Phenylalanine, L-Tyrosine, and L-DOPA, what other compounds from the 2Cx family will follow suit? Earlier this week I was also working on pro-drugs for amphetamine and methamphetamine, but I scrapped that idea because either the resulting molecule would competitively inhibit the enzymes, or it would not act as a substrate for those enzymes.
 
^Check out symyx. It generates text from structure and vice versa, is easy to use and free. There are already loooods af amp/mamp prodrugs (Vyvansem isn't it?).
 
The software is called Symyx Draw right? Thanks for that bro, I appreciate it. One thing I have noticed which completely boggles my mind, is the fact that L-alpha-methylphenylalanine, L-alpha-methyltyrosine, and L-alpha-methylDOPA competitively inhibit AADC and AAAH, yet L-alpha-methyltryptophan is metabolized into L-alpha-methyl-5HTP, and then into alpha-methyl-5HT! What is up with that?
 
Ask a pharmacologist, not a guy who learned to extract mesaline in his garage, is my advice. The software is ISIS/symyx/Accelerys (all same thing I think), then there's other things for smasing small drugs into proteins, which I presume you want to.
 
Yeah, by all means, ask them. I am not one of them. Ask me how to sort out an emulsion in your STB xtraction. Ask me that, I'll tell ya. All that shit up there is BEYOND ME. Took me 3 fucking cracks to draw the right structure,ffs. I do what I can, but I know when I'm out of my league. Also, I don't get the bold green bits in my UN in your post, explain them or leave them obscure, as you wish. Hope all is good, playa.

Also, does anyone know how I can make a phenyl ring appear with 6 single bonds and and unbroken internal ring, rather than alternating single and double order bonds? I prefer the former, but the latter seems to be the default. In Accelerys, or w/e it is these days. plz thx plur etc
 
haha no prob :) its obscure, i know. i did the same thing with your user name immediately after that comment was made (i wanna say a month or two ago), dunno if anyone caught it then. ;)
 
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