I Like to Draw Pictures of Random Molecules

[babylonboy]

i tried yours. TheNightWaTch was my best shot, sorry. tHenigHtwAtch was seriously my second best shot. Here's a dollar, buy a vowel, yeah?

 

[pharmakos]

i'll take a U plz.

 

[babylonboy]

TheUunIgHtWaTch

Uranium and ununtrium go for more than a dollar, btw. PM me.

 

[pharmakos]

we're getting offtopic, so here's some chemwank from a lay man

no idea if i could squeeze more fluorines on there

and i know my amine isn't quite right. couldn't get it right with this lame online java chem sketch app i found.

 

[babylonboy]

So you thought, "2ct4, that's everyones fave, lets make it way more expensive"? Still not tried the legendary DO/2C-TFM meself, meant to be v. good and potent, perhaps something to this. Dunno why, just seems like a lot of electronegativity up on that 4-position, is that OK? Might it hinder BBB passage? Real scientists, say something sensible!

 

[MrKhazar]

At first I almost had a heart attack because the amine did not have 3 covalent bonds attached to it, but then I read your excuse and heaved a sigh of relief haha. I guess organic chemistry and OCD mix very well. Anyway, that molecule looks like 2C-TFM on steroids. I can't even name that thing! If it ends up being a viable compound, turn it into another NBOMe as well.

 

[babylonboy]

[4-2-[1,1,1,3,3,3-hexylluoryl]propyl- 2,5,dmpea, no? or 4-sec[1,1,1,3,3,3-hexafluoropropyl- 2,5,dmpea? tnw, GET ISIS DUDE! it'll generate IUPAC names and SMILES codes from structures, and vice versa. It's not chemdraw, but i can't find free chemdraw anymore, so it works fine. Might even prefer it now I'm used to it.

Yeah, the 4-methyl that would be chiral if it didn't have identical groups on other side, that one doulc have one more F. For good measure or whatever.

Also, Fs all the way round the aryl ring, TFM groups on the Os, Fs on the amine nitrogen (is it even an amine then?), Fs on the aliphatioc chain. It's like you haven't even tried to make a highly fluorinated drug, If you see a hydrogen, or a higher-order bond, you can have more fluorine. Why, I dunno.

MrK, I didn't even notice that hypovalent N, I guess I'm just used to assuming that valencies are satisfied by H unless otherwise informed, with C atoms, and extrapolated without thinking. Did that really bother you?

tnw, three marks down. No beta ketone, no methylendioxyring, no alpha methyl (well, a-TFM, ofc!). Very disappointed. See me after class.

 

[pharmakos]

tnw, three marks down. No beta ketone, no methylendioxyring, no alpha methyl (well, a-TFM, ofc!). Very disappointed. See me after class.

if you look back many pages, i drew LSD with a methylenedioxy and an nbome on it =p

and that name you came up with looks right to me.

 

[babylonboy]

http://accelrys.com/products/informatics/cheminformatics/draw/no-fee.php

naming ain't hard, just methodical. at any rate, draw a chem, and the program will give you the IUPAC, and a smiles code so others can recreate it. DL it now, or we can;t be friends anymore

 

[pharmakos]

oh, just realized...

[4-2-[1,1,1,3,3,3-hexylluoryl]propyl- 2,5,dmpea, no?

should be 4-2-[1,1,1,3,3,3,-hexafluoro]-isopropyl-2,5-dimethoxyphenethylamine i believe

 

[babylonboy]

Isn't that what the 2 at the very start means? Anyway, this is why names are shit, end up arguing over nomenclature more than anything else. Just draw the fucker, then we all know what we're talking about. Anyway... INSTALL BASTARD ISIS and it'll tell us.

 

[sekio]

im just gonna leave this here
http://web.chemdoodle.com/demos/iupac-naming

 

[pharmakos]

don't think that's what that 2 means. in fact, i'm not entirely sure that 2 belongs there at all.

see: the name of 2C-T-21, 2,5-DIMETHOXY-4-(2-FLUOROETHYLTHIO)PHENETHYLAMINE

i hope our bumbling isn't annoying the true scientists that read this thread

i suppose thats why us amateurs get quarantined to these stickies =p

im just gonna leave this here
http://web.chemdoodle.com/demos/iupac-naming

with that i get:

2-{2,5-Dimethoxy-4-[2,2,2-trifluoro-1-(trifluoromethyl)ethyl]phenyl}ethylamine

 

[babylonboy]

2-[2,5-dimethoxy-4-[2,2,2-trifluoro-1-(trifluoromethyl)ethyl]phenyl]ethanamine. More important than a name refers to one compound than that a compound has one name; were my tweeky creations ambiguous? With 2Cs, the 2- means the ortho position relative to the alkylamine chain. With alkanes, I understood the meaning of the two was equivalent to sec, to show that it bonded at the central, secondary C, not either terminal primary C.

Yeah, I was taught to find the longest alkane chain present (the (iso)propyl) and name from there. Oh well. I had hoped sekio might, being a chemist, help others who are obviously trying to learn to understand their mistakes. Any chance, dude, please?

Also- just fuckin' draw the thing. Always FTW!

 

[pharmakos]

wish i could just email sasha and ask him what he would name it

2,5-dimethoxy-4-(2,3-hexafluoroisopropyl)phenethylamine?

 

[babylonboy]

You prolly can. I reckon di-TFM-2C-D, or hexafluoro-2C-iP. He's more a man of the people, likes to share, prefers to get knowledge out there than use esoteric jargon as an exclusive cant to preserve privilege to the ingroup. Heck, let's just call it Ununbabohellahalonium. Sasha was partial to a whimsical name himself (Beatrice? Flea? Iris?) See, names are so unimportant, they're just a way for those in academia and research to try to keep the little people, like us, out. I mean, we all knew what chemical we were talking about; isn't that the sole purpose of a name, at least for a chemical that hasn't even been synthesised, to identify it unambiguously? If one likes not a name, I suggest they explain why it is wrong, y'know, take a moment to explain and help understand. I think we've probably come up with several unambiguous names here, and unless the IUPAC are a-knocking, we'll be ok.

 

[Lightning-Nl]

^^

Thanks for that, I've been playing around with it. But I've got a few questions if someone wouldn't mind answering them for me. Specficially - I was playing around with the idea of "Methylenedioxypropylhexedrine", but noticed that the tool wouldn't allow me to positively charge the carbon off of the amide. Why is this?

Spoiler: Molecule

I think it has something to do with the Nitrogen bond, and the fact that doing so would make the molecule way more polar, or non-polar than physically possible. But I don't know... that's why I'm asking.

 

[sekio]

Maybe you need to put hydrogens on it?

NSFW:

 

[babylonboy]

sekio, do you use that? it seems like it sucks so hard next to ISIS

 

[SeenSoFar]

First off, the IUPAC name of the compound under discussion is 2-(4-(1,1,1,3,3,3-hexafluoropropan-2-yl)-2,5-dimethoxyphenyl)ethanamine. Here is it drawn by ChemDraw Pro:

NSFW:

... With alkanes, I understood the meaning of the two was equivalent to sec, to show that it bonded at the central, secondary C, not either terminal primary C...

When you're refering to a branched proply structure, it is referred to as iso, not sec. There is no sec-Propyl, only n-propyl and isopropyl. It's only when you extend the alkyl chain to butyl that you can have the option of n-, iso-, sec- and tert- butyl.

^^

Thanks for that, I've been playing around with it. But I've got a few questions if someone wouldn't mind answering them for me. Specficially - I was playing around with the idea of "Methylenedioxypropylhexedrine", but noticed that the tool wouldn't allow me to positively charge the carbon off of the amide. Why is this?

Spoiler: Molecule

I think it has something to do with the Nitrogen bond, and the fact that doing so would make the molecule way more polar, or non-polar than physically possible. But I don't know... that's why I'm asking.

Why would you like to have a carbonium cation on your N-methyl? I don't understand why this is something you would want... It would be far too polar to cross the BBB from what I know...

Also, the aromatic ring is required for SERT and DAT affinity. You would probably end up with something that was NE specific, if active at all I would think.