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I Like to Draw Pictures of Random Molecules

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5-MAPDB
5-MAPDB_structure.png


6-MAPDB
6-MAPDB_structure.png


Would anyone else like to see these two made and tested? I've always wondered about their effects....
 
I don't get it... ethylphenidate and 3,4-dichloroRitalin are both a bit shit, let's make them breed, maybe they'll produce something really shit? If those drugs are your cup of tea, fair play, but I can't see them being much fun. Likewise, are 5-APB and n-ethylMDA the kind of big winners we want to explore the derivatives of? Not to piss on your cornflakes, I just don't quite understand the appeal. By the way, it looks like you're using paint or something to add alkyl groups to preexisting skeletal formulas, Symyx draw is free and is what I use. It's not as good as ChemDraw, but it's a million percent more free.

JG, those things look a bit like naphyrone to me, which wasn't well recieved. There's other bicyclic amphetamines, too, but I unfoundedly feel like phenmetrazine/aminorex type things are the most promising designer stimulants of the future.
 
^The saturated analogues (5- and 6-aminopropylbenzodihydrofuran) are already available, it's only the N-alkylation that would be novel.
 
ethylphenidate and 3,4-dichloroRitalin are both a bit shit
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Have there been sufficient human bioassays to establish the latter as shit?

JG, those things look a bit like naphyrone to me, which wasn't well received.
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Such a wide array of miscellaneous cathinones was sold as naphyrone that the compound hasn't really yet been received at all.

ebola
 
^It's been sold by UK vendors under the name 3,4-CTMP for over a year, quite a lot of EADDers have tasted it, the consensus is that it's even more rubbish than ethylphenidate. There's a thread here about it, there's probably others, but given the fondness of Brits for stimulant RCs, I think the fact that no-one's particularly bothered about it says a lot. My unscientific impression is that people would opt for methiopropamine or ethylphenidate over it, which makes me think it's not the best thing since sliced bread.
Such a wide array of miscellaneous cathinones was sold as naphyrone that the compound hasn't really yet been received at all.
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Very true.
 
No offense taken babylonboy, it's a perfectly valid complaint, so let me explain.

The reason for the eph/3,4-ctmp variations is that I like eph a lot, so I bought some 3,4-ctmp hoping to get something similar with a longer duration and lower dose. What I got was rubbish that I barely feel (30mg ~ about a cup of tea, when 10mg should provide long lasting stimulation). Now it's possible that I was scammed by the vendor, but I bought it twice from two different vendors. Each time it looked/tasted the same + the second vendor is one that I've been using for years and has never screwed me before. So I guess 3,4-ctmp = crap for me. This made me wonder how a few simple modifications would affect it, hence the drawings.

The 5 and 6 MAPDBs are also something I'm interested in. I liked the benzofurans I tried (5 and 6 apb, 5 mapb, 5 apdb (this one more as a replacement for mdai)) and heard good things about 6-mapb and 6-apdb. The mapdbs are kinda a logical extension of that. The eapdb is something for people from the UK where the others are illegal (but I guess it's to late to try it, since all benzofurans will be illegal soon). The bk benzofurans are another thing I'd like to see tested, who knows, it may suck, be average or really good. Methylone and bk-2c-b turned out ok. And now knowing from bk-2c-b that bk primary amines can be stable enough we may see bk-mda.

And you don't really think that 6-allyl-6-nor-lysergic acid 2,4-dimethylazetidide or al-lsz is boring, right?

Oh, and thanks for the drawing program!
 
5/6-MAPB are already available. The reports say it feels very similar to MDMA.

The only problem I have with these saturated compounds, that if you look at 5-MADPB for example, if you break up the tetrahydrofuran part you immediately get 4-methoxy-3-hydroxy-methamphetamine (HMMA) which is a known neurotoxic having its part in MDMA's neurotoxicity. But I don't know enough about metabolism to predict if this actually happens so maybe someone with more knowledge can shed some light on it. I also don't know if this happens in unsaturated compounds so I have to read a bit into 6/5-APB metabolism. If it does happen then 5/6-MAPDB would be safer than 5/6-APDB because the latter would then produce HMA which is more toxic then HMMA.
 
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babylon said:
people have used [brephedrone] recreationally and not suffered horrendous neural damage.
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Well, those involved in trials of PCA as an anti-depressant tolerated it well and didn't notice the horrendous neurotoxicity they incurred for a matter of years, if at all.

ebola
 
I don't think that releasers fare well with cyclized groups added to the amine, though incorporation of the alpha-carbon tail is pretty novel, but it's not even clear whether it should be judged in terms of stimulant SAR of any sort.

ebola
 
Just a quick one here, I'm away from my computer and so I can't look this one up properly or draw it for you, but it's extremely straightforward. The previous compound brought up one I've been thinking about lately. I'm curious if benzylpiperidine or 3,4-methylenedioxy-benzylpiperidine have ever been studied. If not, why? It seems like the logical step in between amphetamine and BZP. Also, any results might be applicable to the 3,4-methylenedioxy-benzylpyrrolidine suggested by buildersoftime.
 
Ethylphenidate is proof that NE activity is required for some people to have fun. We certainly learned something from it, most people who hated it were mad because it was promoted as a cocaine replacement. Oddly it seems to be a more practical therapeutic drug than MPH for this reason. Some people also thought the "legendary" amfonelic acid was boring.

2-benzylpiperidine was apparently disappointing. 4-benzylpiperidine is an active NDRI. 3-benzylpiperidine has yet to be examined.

Ebola: such metabolic transformation of APDB compounds is unlikely. In addition, they were less toxic in rats than was MDA itself. This is another reason I'm annoyed the ACMD lumped these in with the APBs.
 
toastmann said:
5/6-MAPB are already available. The reports say it feels very similar to MDMA.

The only problem I have with these saturated compounds, that if you look at 5-MADPB for example, if you break up the tetrahydrofuran part you immediately get 4-methoxy-3-hydroxy-methamphetamine (HMMA) which is a known neurotoxic having its part in MDMA's neurotoxicity. But I don't know enough about metabolism to predict if this actually happens so maybe someone with more knowledge can shed some light on it. I also don't know if this happens in unsaturated compounds so I have to read a bit into 6/5-APB metabolism. If it does happen then 5/6-MAPDB would be safer than 5/6-APDB because the latter would then produce HMA which is more toxic then HMMA.
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I know about 5/6 mapb. Only tried 5-mapb so far, but a 6-mapb sample is going to be here soon. For me the 5-mapb was a bit worse that a 5/6 apb combo, but then I like the trippyness of that. Guess I'm more of a mda person. For someone that doesn't want that, I can see 5-mapb being better. As far as 5/6 mapdb according to a few vendors they were in the plans but since the UK ban I guess it's not really that profitable any more (the vendors I talked with had the UK as their mayor market). So until some one rich pays for a synth it's an open question on how pleasurable the effects are. And I'd not be so fast to call things neurotoxic just buy speculations (note, a warning of the posssibility is of course totally different and fine) on their metabolism. As far as I know not much scientific research was done on any of the benzofurans. Not that I'm calling them safe, just saying more research is needed before saying either way. Besides, who knows, perhaps the mapdb compounds are crap effect wise and nobody would take them anyway. Personally 5/6 apb, 5-mapb and 5-apdb felt pretty benign to me but it's not like neurotoxicity from a few uses is that obvious unless huge.
 
babylonboy said:
^It's been sold by UK vendors under the name 3,4-CTMP for over a year, quite a lot of EADDers have tasted it, the consensus is that it's even more rubbish than ethylphenidate. There's a thread here about it, there's probably others, but given the fondness of Brits for stimulant RCs, I think the fact that no-one's particularly bothered about it says a lot. My unscientific impression is that people would opt for methiopropamine or ethylphenidate over it, which makes me think it's not the best thing since sliced bread.

Very true.
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Agree about 3,4 ctmp. Rubbish. None of the good sides of eph (yeah, I enjoy eph), not active in the low doses some claim... That's why I proposed some mods to it, perhaps ome would turn out nicer.
 
I don't get what you mean. 3-methoxymethcathinone with a carboxylic acid group hanging off the ether carbon, or the methyl ester of 3-hydroxymethcathinone, or what? Could you draw it in Symyx or ISIS?
 
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