Limpet_Chicken
Bluelighter
I know 2-alkyl BENZOfurans are often/usually hepatotoxins, does this apply to furans also?
N&PD Moderators: Skorpio | someguyontheinternet
I was just joking about the MSpaint
I used BKchem to draw those.
Upon further review, it seems the two lone pairs on oxygen are necessary (at least the oxygen in the 4th position) to H-bond with the receptor.
Nitrogen, with its single lone pair + hydrogen would be vastly inferior in this regard. And probably toxic.
There was a thread on here a while back about using "Benzoxazole" (one O and one N) that proved promising...
I wonder if the resonance within the 5-membered ring helps or hurts its potency...
That nitrogen doesn't only have more bonds than electrons in its valence shell, it has more bonds than electrons in all its shells! But I have a feeling Albion knew that his structure might not be the easiest thing to knock up in the labWHY?
The Texas carbons/nitrogens (hypervalent- no carbon has 5 bonds!) are esp. distressing, and the strained double-bonds don't make this molecule look happy either. Nor the ketene moiteys.
This whole thing would just as soon blow up as exist
I'm sure it's fine, no chemists in ADDI apologise to any chemists in the house
That nitrogen doesn't only have more bonds than electrons in its valence shell, it has more bonds than electrons in all its shells! But I have a feeling Albion knew that his structure might not be the easiest thing to knock up in the lab
I'm sure it's fine, no chemists in ADD![]()
The bases are pretty much covered, ketamine/tiletamine etc at the 2, methoxetamine and the 3-MeO-PCxs at the 3, 4-MeO-PCP apparently demonstrating that the para is not where the action is.Yeah it's obvious where this goes really, next step is a walk around the benzene ring.